Curcumin attenuates neurotoxicity induced by fl uoride: An in vivo evidence

Abstract

Background: Curcumin (Cur), an active ingredient of turmeric is known to have multiple activities, including an antioxidant property and has been suggested to be useful in treatment of several neurological diseases.Objective: To investigate the neuroprotective effects of Cur to mitigate the effect of the Fluoride (F) induced neurotoxicity in mice brain using the histological and the biochemical parameters.Materials and Methods: Exposure of mice (30 days old male) to F (120 ppm) daily for 30 days. Result and Discussion: Treatment with the F causes an increase in lipid peroxidation (LPO) and also increase in the neurodegenerative cells in the hippocampal sub-regions. Interestingly, co-treatment with Cur (30 mg/kg BW) with F (120 ppm) for 30 days results in signifi cant decreases in LPO with a concomitant decrease in neurodegeneration as compared with those treated with F alone.Conclusion: Our study reveals that Cur is useful in ameliorating degenerative effects of F in mice brain.

Keywords: Curcumin; neurodegeneration; neuroprotection; lipid peroxidation; oxidative stress; fl uoride; histology