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PM · Lens · Betulinic Acid from Zizyphus Joazeiro Bark Using Focused Microwave-Assisted Extraction and Response Surface Methodology Fernanda Carolina Sousa Fonseca, Letícia Caribé Batista Reis, Jener David Gonçalves dos Santos,

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Article · Volume 13, Issue 50 · pp. 226–229

Betulinic Acid from Zizyphus Joazeiro Bark Using Focused Microwave-Assisted Extraction and Response Surface Methodology Fernanda Carolina Sousa Fonseca, Letícia Caribé Batista Reis, Jener David Gonçalves dos Santos,

Carla Rodrigues Cardoso Branco1, Sergio Luis da Costa Ferreira2, Jorge Mauricio David2, Alexsandro Branco1

  1. 1Department of Health, State University of Feira de Santana, Feira de Santana, Brazil.
  2. 2Department of Organic Chemistry, Federal University of Bahia, Salvador, Bahia, Brazil.

Abstract

Background: The effect of the extraction time (min) and temperature (ºC) on the yield of betulinic acid (BA) from Zizyphus joazeiro barks using focused microwave-assisted extraction was investigated.Materials and Methods: The ethyl acetate was used as extractor solvent because it was shown to provide a betulinic acid-clean extract. A full two-level statistical factorial design was applied to determine the important effects and interactions of these independent variables upon the yield of BA.Results: The conditions that produced the highest yield of BA were at temperature of 70 ºC and an extraction time of 15 min (3.33 mg per gram of plant).Conclusion: The BA has drawn attention due to its use as a raw material in the synthesis of active compounds against the Human Immunodeficiency Virus (HIV).

Keywords: Betulinic acid; experimental design; focused microwave‑assisted extraction; Zizyphus joazeiro

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