Article · Volume 15, Issue 60 · pp. 18–23
Evaluation of Anti-inflammatory and Antioxidant Activities of Cissus quadrangularis Stem Extract
Xiaoying Chen1, Shuangshuang Qin1, Cui Li1, Qinghua Wu1, Chao Jiang2, Jian Yang2, Xiaoyun Guo1, Chunli Ou1
- 1Guangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China.
- 2National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Abstract
Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> (CQ) is a well-known medicinal plant used in traditional medicine for bone healing.Objective: The present study was aimed to evaluate the anti-inflammatory and antioxidant activities of the methanolic extract of <em>Cissus quadrangularis</em> stem (MECQ).Materials and Methods: The anti-inflammatory activity was evaluated using the carrageenan-induced rat paw edema model. The antioxidant activity was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, ferric reducing antioxidant power (FRAP) assay, and total phenolic content (TPC) determination.Results: MECQ showed significant anti-inflammatory activity in a dose-dependent manner. It also exhibited potent antioxidant activity with high TPC.Conclusion: The results suggest that MECQ possesses significant anti-inflammatory and antioxidant activities, which may be attributed to the presence of phenolic compounds.
Keywords: Chlorogenic acid; gene expression; Lonicera japonica Thunb; luteoloside; phytohormones
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