Volume 18, Issue 80

Original Article(continued)

1. Article

   Predicting the Targets of Mangiferin in the Treatment of Diabetes Mellitus on Network Pharmacology and Analysis of its Metabolites in vivo

   Ying Wei, Xiaojuan Li, Xiulan Su, Tunhai Xu

   pp. 1137–1145 · DOI: 10.4103/pm.pm_5_22 · 2022

   Objectives: The purpose of our study was to investigate the targets and mechanism of mangiferin in the treatment of DM and to analyze its metabolites in vivo. Materials and Methods: We predict the targets and mechanism o…

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2. Article

   Network Pharmacology Analysis and Experimental Validation of the Antidepression Mechanism of Lactuside B

   Bingxuan Niu, Shengying Li, Chunyan Li, Yu Song, Hui Zhang, Huifang Niu, Ruifang Hua, Fulin Yan, Guangfan Hai

   pp. 1146–1152 · DOI: 10.4103/pm.pm_79_22 · 2022

   Objectives: This study was the first to study the pharmacological effects and mechanisms of LB on depression. Materials and Methods: Network pharmacology method was applied to screen the candidate targets and signaling p…

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3. Article

   Anwulignan Attenuates Remote Renal Injury Induced by Intestinal Ischemia/Reperfusion in Rats

   Shu Jing, ChunRong Yu, ZiQi Song, HuiJiao Lin, Jia Wei Liu, Chunmei Wang, He Li, Dan Wang, Jianguang Chen

   pp. 1153–1159 · DOI: 10.4103/pm.pm_578_21 · 2022

   Aim: Intestinal ischemia/reperfusion (II/R) can cause injury of remote organs, including acute renal injury. All of these, in turn, increase the rate of disability and mortality. Anwulignan (Anwu) is an active monomer fr…

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4. Article

   Integrating Background Subtraction and Metabolomics Technology to Study the Difference of Serum Chemical Profile Before and After Compatibility of Radix Bupleuri and Radix Paeoniae Alba

   Congcong Chen, Ruihong Hou, Qicai Yin, Junshen Tian, Xiaoxia Gao, Xuemei Qin, Guanhua Du, Yuzhi Zhou

   pp. 1160–1169 · DOI: 10.4103/pm.pm_139_22 · 2022

   Objectives: Here, an effective strategy has been developed for screening differences of constituents in vivo before and after compatibility by integrating background subtraction and metabolomics technology. Materials and…

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5. Article

   Anti‑cancer effect Shikonin on Ferric Nitrilotriacetate‑induced Renal Cancer Rats Apoptosis Mediating PEG2/NF‑κB Signaling Pathway

   Dong Wang, Yahong Lu, Wenjing Meng, Tao Shu, Zengyue Yang

   pp. 1170–1176 · DOI: 10.4103/pm.pm_517_21 · 2022

   Objectives: The research aimed to study the anti‑cancer effect of SKN in diethylnitrosamine (DEN) and ferric nitrilotriacetate (Fe‑NTA)‑induced renal carcinoma in rats. Materials and Methods: The experimental animal grou…

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6. Article

   Cardioprotective Effect of Gedunin on Isoproterenol‑Induced Cardiotoxicity through the Attenuation of NF-κB‑Mediated Inflammatory Pathway in Rats

   Yongle Sun, Hongwen You

   pp. 1177–1182 · DOI: 10.4103/pm.pm_29_22 · 2022

   Background: There is an increasing interest in new natural compounds for the treatment of myocardial infarction (MI). Gedunin is a tetranortriterpenoid extracted from the Indian neem tree (Azadirachta indica). The main o…

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7. Article

   Apoptosis‑Mediated Anticancer Activity of Geraniol Inhibits NF‑κB, MAPK, and JAK‑STAT‑3 Signaling Pathways in Human Thyroid Cancer Cells

   Hongli Yang, Yonggang Zhang, Jianying Cui, Zhi Hao

   pp. 1183–1189 · DOI: 10.4103/pm.pm_223_21 · 2022

   Aim: Thyroid cancer accounts for 3.8% of the total endocrine cancer and is the fifth most diagnosed cancer among Indian women. Geraniol possesses pharmacological properties, including anti‑inflammatory, anti‑cancer, and …

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8. Article

   Withaferin A Attenuates Epithelial-Mesenchymal Transition and Cancer Stem Cells Properties in Hepatocellular Carcinoma Cells by Inhibiting the PI3K/AKT Pathway through miR-200c

   Hui Tian

   pp. 1190–1195 · DOI: 10.4103/pm.pm_86_22 · 2022

   Objectives: The present study was aimed at elucidating the mechanism of action of withaferin A against hepatocellular carcinoma (HCC) cells via the PI3K/AKT signaling pathway. Materials and Methods: MTT (tetrazolium dye)…

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9. Article

   HPLC Determination of Anti‑cancer Components Isolated from Rabdosia rubescens

   Hong-Xin Cui, Fang-Rong Cheng, Ke Yuan

   pp. 1196–1201 · DOI: 10.4103/pm.pm_30_22 · 2022

   Background: Rabdosia rubescens is a traditional herbal medicine, commonly known as an anti‑cancer plant. A large number of literatures have reported that the diterpenoids in R. rubescens have strong anti‑tumor effects. T…

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10. Article

    Degalactotigonin Inhibits Invasion and Induce Apoptosis by Targeting TGF‑β Signalling in Oral Cancer Cells

    Yang Li, Chengnan Gu

    pp. 1202–1210 · DOI: 10.4103/pm.pm_7_22 · 2022

    Objectives: The study aimed to investigate the anti‑invasion and apoptotic induction effect of DGT in oral squamous cell carcinoma (OSCC) cells through inhibiting non‑canonical TGF‑β signalling. Materials and Methods: Hu…

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11. Article

    miR‑223‑3p Promotes Ulcerative Colitis Progression in Rhubarb Decoction‑Induced Rats with the Spleen‑Kidney‑Yang Deficiency

    Model by Regulating the TGF‑β/Smad3 Pathway Shiju Liu, Huijian Zhang, Junhong Liu, Xinchun Zhang, Xiang Liu, Yapeng Sun, Yan Li, Jie Wang, Dianwen Liu

    pp. 1211–1216 · DOI: 10.4103/pm.pm_266_21 · 2022

    Background: Ulcerative colitis (UC) is a prevalent case which needs more detailed exploration. We attempted to illustrate how miR‑223‑3p acted in the development of UC. Materials and Methods: The level of miR‑223‑3p in s…

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