Volume 19, Issue 4

Sachin Kumar, Ashok Kumar, Suhasini Nayal, Aman Shukla, Shashank Kailkhura

pp. 799–810 · DOI: 10.1177/09731296231197306 · 2023

Medicago sativa is the “Father of all herbs” or “King of Herbs,” and Panax ginseng is the “‘Man root” or “Herb for all healings.” Individually, both have copious numbers of phytochemicals and nutrients like flavonoids, s…

Xiao-Hui Li, Ke-Xin Liu, Zhi-Bin Ding, Qing Wang, Li-Juan Song, Jie-Zhong Yu, Dong Ma, Bao-Guo Xiao, Cun-Gen Ma

pp. 811–821 · DOI: 10.1177/09731296231171454 · 2023

Background: Ginkgolide K (GK) has a protective effect on neurons and myelin sheath, and the function of astrocytes in phagocytizing myelin debris has attracted extensive attention in remyelination. Objectives: This study…

Fatma Hacet, Eda Becer, Hafize Seda Vatansever, Sevinç Yücecan

pp. 822–830 · DOI: 10.1177/09731296231187443 · 2023

Background: This study aimed to establish an in vitro model of Alzheimer’s Disease (AD) to investigate the neuroprotective activities of allyl isothiocyanate (AITC) and sulforaphane (SFN). Materials and Methods: Human ne…

Chao Xu, Xiang Chen, Jing Han, Yufei Chen, Chongyu Ge, Liwei Wang, Rong Yang, Yuping Shen, Huan Yang

pp. 831–840 · DOI: 10.1177/09731296231188779 · 2023

Background: Vinegar-quenched Testudinis Carapax et Plastrum (TCP) and vinegar-quenched Trionycis Carapax (TC) are made from the shells of Chinemys reevesii and Trionyx sinensis. However, some cheap substitutes from non-m…

Jia Li, Tingting Chen, Zhanting Yang, Shanshan Su, Yuhua Wang, Zhanqiang Li, Dianxiang Lu

pp. 841–852 · DOI: 10.1177/09731296231194402 · 2023

Background: Pulmonary hypertension (PH) is a pulmonary vascular disease caused by a variety of causes and has a poor prognosis. Hypoxic pulmonary hypertension (HPH) is one of the types of PH. Cordyceps sinensis could tre…

Jichao Liu, Dong Yang, Jianyu Liu

pp. 853–861 · DOI: 10.1177/09731296231184539 · 2023

Background: Osteosarcoma (OS) is an extremely aggressive primary bone cancer (BC) malignancy. A variety of malignancies can develop in the bones, including BC. Primary BCs are tumors that start in the bone. Bones can als…

Tesfay T. Tesfatsion, Giovanni A. Ramirez, Maite L. Docampo-Palacios, Arianna C. Collins, Kyle P. Ray, Westley Cruces

pp. 862–873 · DOI: 10.1177/09731296231195941 · 2023

Introduction: Cannabidiol (CBD) is one of many naturally biosynthesized compounds produced by Cannabis sativa. There is limited information available in the literature on hydrogenated CBD (tetrahydro cannabidiol or H4CBD…

Lei Wang, Xiaoqin Bie, Suresh Mickymaray, Abdulaziz S. Alothaim, Yan Pei, Huaping Gong

pp. 874–884 · DOI: 10.1177/09731296231183833 · 2023

Background: Colon cancer continues to be the third most commonly occurring cancer around the globe with both lifestyle-related risk factors and genetic dispositions. Owing to the increased incidence of the disease, there…

Jinhua Zhang

pp. 885–897 · DOI: 10.1177/09731296231189095 · 2023

Introduction: Lung cancer (LC) ranks among the most prevalent malignant neoplasms globally. As a Traditional Chinese medicine (TCM), Herba Epimedii has been commonly used for treating LC. However, the specific mechanism …

Cuizhu Zhuo, Xiaolin Wang, Yun Li, Yongmei Tang, Manman Wang, Liying Hou

pp. 898–905 · DOI: 10.1177/09731296231188792 · 2023

Background: Apigenin effectively inhibits the growth of human gastric carcinoma SGC-7901 cells and induces apoptosis as well. This study investigated the effects of ATF6 and PERK signaling pathways in unfolded protein re…

Shaomei Lin, Yunzhu Shen, Xiaowei Huang, Shifeng Lin, Xiaoning Shi

pp. 906–916 · DOI: 10.1177/09731296231193801 · 2023

Background: Diabetic neuropathic pain (DNP) is a serious chronic complication of diabetes mellitus. Oxidative stress and inflammation are considered the central mechanisms of its pathogenesis. Schefflera arboricola (SA) …

Cheruthazhakkat Sulaiman, Thankayathil Shafna, Geetha Raguthaman Advaya, Poovathusseri Raghava Varier Ramesh, Kamalakshan Pillai Mahesh, Mooriath Praveen, Erayur Mana Anandan, Indira Balachandran

pp. 917–925 · DOI: 10.1177/09731296231200365 · 2023

Background: Guggulutiktam Kashayam (GTK) is a water decoction used in Ayurveda for the treatment of various diseases like skin diseases, ulcers, anemia, thyroid problems, stress, liver disease, and leucorrhoea. It is a p…

Yuanfeng Shen, Lu Zhang, Aihui Hou, Kaviya Suresh, Anbarasan Balu, Zhe Gong

pp. 926–936 · DOI: 10.1177/09731296231183277 · 2023

Background: Nasopharyngeal carcinoma (NPC), predominant in Southern China and Southeast Asia, is a malignant tumor that arises from the epithelial lining of the nasopharynx. Current NPC treatments result in unfavorable s…

Ju Zhang, Bing Wang, Guanglin Zhu, Guo Feng, Wei Li, Hongmei Su, Wenjing Wang, Xie-an Yu, Xueli Song, Zhengyan He

pp. 937–945 · DOI: 10.1177/09731296231191375 · 2023

Background: Asparagi Radix (AR) is one of the widely used Traditional Chinese Medicines (TCMs) for clinical applications, owning the effects of clearing the lungs and promoting body fluid, nourishing yin, and moistening …

Lingai Hu, Yukun Sun, Hongsheng Zhang, Yong Cao, Jinguo Zhang

pp. 946–953 · DOI: 10.1177/09731296231189557 · 2023

Background: Myocardial infarction (MI) is a leading cardiovascular disease worldwide, with high mortality. Purpose: The study aimed to observe the mechanism of catalpol inhibiting apoptosis and autophagy in H9c2 cells af…

Xiaoyang Gong, Jiaqi Zhou, Haonan Xia, Chong You, Yong Liu

pp. 954–966 · DOI: 10.1177/09731296231189106 · 2023

Background: The purpose of this study was to investigate the molecular mechanisms and material basis of Huangqi Guizhi Wuwu Decoction (HGWD) in treating clinical Ischemic stroke (IS) using network pharmacology and molecu…

Xin Liu, Xu-ying Huang, Zhong Liu, Li Liu, Han Tu

pp. 967–980 · DOI: 10.1177/09731296231189553 · 2023

Background: Coptis chinensis Franch. (CCF) is a Traditional Chinese medicine known for its good anti-cancer effects. However, the bioactive compounds and mechanisms underlying its anti-colorectal adenocarcinoma (COAD) re…

Yi Wen, Changda Li, Yifan Zeng, Chanyuan Zhou, Qiang Zhang, Tianshu Gao

pp. 981–993 · DOI: 10.1177/09731296231189561 · 2023

Background: The thyroid is the prime organ of infection during the onset of autoimmune disease. The disease is known as Autoimmune thyroiditis (AIT). In recent times, AIT has been alarming worldwide, with growing attenti…

Xia Meng Zhang, Zehong Ma, Chengjian Mao, Jihong Zhang, Zhongdanni Ma

pp. 994–1002 · DOI: 10.1177/09731296231197077 · 2023

Background: Endothelial cell (EC) inflammation plays a crucial role in the development of several cardiovascular disorders (CD), including atherosclerosis and sepsis. Ligustrazine (Lig), a bioactive constituent derived f…

N. V. Prasanth, P. Pandian, T. Balasubramanian

pp. 1003–1011 · DOI: 10.1177/09731296231200509 · 2023

Background: Alzheimer’s disease (AD) is considered to be the most common form of dementia. The drugs that are available for the treatment of AD provide only partial improvement of the condition. In recent years, natural …