Volume 22, Issue 2

Xiaoming Yan, Yao Chen, Qiang Zhao, Shihua Yi, Ming Chen, Yingying Fang

pp. 415–427 · DOI: 10.1177/09731296251368703 · 2026

Background: Renal interstitial fibrosis (RIF) is a common pathological change in chronic kidney disease (CKD). Many CKD patients exhibit varying degrees of disruption in iron and lipid metabolism. Ferroptosis, a unique f…

Dakai Qin, Qinyuan Zhang, Demin Lin, Maoqin Yang, Dexiang Ren, Yunyun Fu, Xiaojun Xia, Xudong Lei

pp. 428–436 · DOI: 10.1177/09731296251372724 · 2026

Background: Lung cancer is a highly lethal malignancy that affects millions of people worldwide. Treatment remains challenging, particularly due to tumor invasion and metastasis. While previous studies have explored vari…

Lin Yuan, Yang Chen, Yanmei Guan, Xiujuan Fu, Linyan Tan

pp. 437–454 · DOI: 10.1177/09731296251341498 · 2026

Background: Bioactive compounds from natural sources have been integral to traditional medicine, providing therapeutic benefits for centuries. Their efficacy in treating skin disorders highlights the ongoing relevance of…

Jialu Cao, Geng Zhao, Yutong Jiang, Bingyuan Zheng, Qian Liu, Ke Liang, Tie Qiao

pp. 455–466 · DOI: 10.1177/09731296251400031 · 2026

Background: Depression, often accompanied by cognitive impairment, remains a major clinical challenge due to the limited efficacy and side effects of conventional anti-depressants. The herbal pair of Ginseng and Polygona…

Ying Ma, Lan Cui, Qi Zhao

pp. 467–474 · DOI: 10.1177/09731296251340466 · 2026

Background: Diabetic retinopathy (DR) is a severe microvascular complication of diabetes and a leading cause of vision impairment worldwide, with inflammation and apoptosis playing crucial roles in its pathogenesis. Obje…

Ajay Gupta, Alok Agarwal, Satish Agarwal

pp. 475–489 · DOI: 10.1177/09731296251363219 · 2026

Background: Osteoarthritis (OA) is a common degenerative joint disorder characterized by pain, stiffness, and reduced mobility, impacting the quality of life. Extracts from turmeric (Curcuma longa) and Boswellia (Boswell…

Lin Xu, Yongcan Chen, Yang Sheng, Xiaoxi Zhang, Meihong Ding

pp. 490–496 · DOI: 10.1177/09731296251342353 · 2026

Background: Astragalus and Five-Ginseng Decoction is a traditional Chinese medicine formulation designed to address symptoms of chest obstruction, heart failure, and palpitations associated with Qi and Yin deficiency and…

Xiong-Bin Cao, Jun Cai, Bo Liu, Xiang-Feng Wu, Zhi-Qiang Wei, Han Luo, Zeng-Xia Zhao, Yong-Zhen Chen, Shuai Li, Li Gong

pp. 497–508 · DOI: 10.1177/09731296251346308 · 2026

Background and Objectives: Parkinson’s disease (PD) is a common age-related neurodegenerative disorder. Mitochondrial dysfunction is considered an important initiating factor for the lack of dopaminergic (DA) neurons. Th…

Qiu-Heng Zhang, Ze Feng Wang, Gu-Zhou Chen, Ruixiang Li, Jiange Zhang

pp. 509–518 · DOI: 10.1177/09731296251346354 · 2026

Background: Rheumatoid Arthritis (RA) is a persistent autoimmune disease. Triptolide (TPL) and celastrol (CEL) are both toxic components derived from traditional Chinese medicine Tripterygium wilfordii, which were proven…

Zhe Li, Lin Li, Qian Liu, Yan Gao, Xing Fan, Qian Wang, Shasha Zang

pp. 519–529 · DOI: 10.1177/09731296251355800 · 2026

Background: Diabetes mellitus is a complex metabolic condition defined by hyperglycemia, leading to various difficulties, including diabetic nephropathy. Diabetic nephropathy is a serious condition of diabetes, defined b…

Bowen Ma, Rui Wang

pp. 530–540 · DOI: 10.1177/09731296251350747 · 2026

Objectives: Atherosclerosis (AS), a significant cause of cardiovascular diseases, is characterized by disrupted lipid metabolism, inflammation, and endothelial dysfunction. We evaluated the effects and mechanisms of a hy…

Xinchun Zhang, Yin Gao, Yonghua Ma, Xuerong Han, Zhibin Liu

pp. 541–551 · DOI: 10.1177/09731296251348012 · 2026

Background: Polydopamine (PDA) shows promising potential in disease diagnosis and targeted drug delivery. Objectives: This study aimed to investigate the role of Paeonol (PAE)-modified PDA nanoparticles (NPs) in the trea…

Ru Gao, Yuhang Guo

pp. 552–564 · DOI: 10.1177/09731296251348000 · 2026

Background: PI3K/protein kinase B (AKT)/glycogen synthase kinase-3β (GSK-3β) regulates the activity of liver cancer cells. However, the poor water solubility of Oroxin A (OA) results in its lack of apparent clinical appl…

Ae Sin Lee, Jinyoung Hur, Sang Yoon Choi

pp. 565–572 · DOI: 10.1177/09731296251355167 · 2026

Background: The vascular endothelium regulates vascular inflammatory responses essential for controlling cardiovascular disease-induced complications. Moreover, regulating intercellular adhesion molecule-1 (ICAM-1) expre…

Xianmei Li, Liangying Liu, Gang Shi

pp. 573–582 · DOI: 10.1177/09731296251346317 · 2026

Background: Bupleurum is an active ingredient extracted from the Chinese medicine bupleurum, which has been proven to have various biological effects, such as anti-tumor, anti-inflammatory, and immune regulation. However…

Shunxin Li, Fanchen Zeng

pp. 583–593 · DOI: 10.1177/09731296251348093 · 2026

Background: Hepatocellular carcinoma (HCC) is a major global health threat with a high mortality rate. Sorafenib, the standard treatment for advanced HCC, is often rendered ineffective by tumor drug resistance, particula…

Baichen Mu, Guoxin Li, Minghua Nan, Lin Ruan, Shuang Li, Wanting Pei, Peiling Yu, Jiangtao Yin

pp. 594–604 · DOI: 10.1177/09731296251362574 · 2026

Background: Coronary artery disease is a common cardiac ailment prevalent worldwide. Objectives: To explore the therapeutic impacts and related mechanisms of Yangxinxue (YXX) granules on myocardial injury. Materials and …

Yuhuai Wang, Ping Wang, Jiaqi Liu, Yeze Yang, Fagen Huang

pp. 605–615 · DOI: 10.1177/09731296251355018 · 2026

Introduction: Panax notoginseng saponins (PNS), extracted from Chinese ginseng, exert various pharmacological activities, including anti-tumor effects. Lung cancer remains the malignancy with the highest morbidity and mo…

Li Tian, Cailin Luo, Yangmin Wen, Zhihua Zheng

pp. 616–625 · DOI: 10.1177/09731296251355166 · 2026

Background: Alcoholic liver disease, a consequence of excessive alcohol consumption, is a major factor contributing to global morbidity and mortality. Salvianolic acid B (Sal B) has demonstrated potential in alleviating …

Haodong Bai, Zidong Zhang, Ping Wang, Yujia He, Yuanning Zeng, Yanping Sun, Qiuhong Wang, Haixue Kuang

pp. 626–639 · DOI: 10.1177/09731296251351369 · 2026

Background: Anemarrhenae asphodeloides polysaccharides (RAP) have demonstrated notable antioxidant activity, which is believed to be closely related to their monosaccharide composition and extraction conditions. However,…