The effect of Venlafaxine on the neuro-behavioral status of mice after administration of chemotherapeutic-neurotoxic agent (Cyclophosphamide)
Maha ElBeltagy1, Lujain AlZoubi2★, Rand B. AbuAnzeh2, Mohammed Yousef2, Yara AlAdwan2, Raha AlZoubi2, Ahmad Salman1★ Corresponding author
- 1Department of Anatomy and Histology, School of Medicine, the University of Jordan, Faculty of Medicine, Department of Anatomy and Embryology, Menoufia University, Egypt.
- 2Faculty of Medicine, the University of Jordan, Amman, 11942, Jordan.
CORRESPONDENCE
Lujain AlZoubi
Faculty of Medicine, the University of Jordan, Amman, 11942, Jordan.
Received: 19-12-2023; Accepted: 17-01-2024.
Volume 22, Issue 4 · pp. 3039 · PUBLISHED 9 October 2024 · DOI: 10.18549/PharmPract.2024.4.3039
ABSTRACT
Background: Cyclophosphamide (CPH) is a cornerstone in cancer therapy and the present study explores the effect of Venlafaxine (VLX) against cognitive deficits induced by CPH in mice and its effect on neurogenesis in the hippocampus. Methods: Forty mice were randomly allocated to four groups: control, VLX, CPH, and CPH+VLX. The Novel Location Recognition model (NLR) test used here is a spatial variant of a two-trial object recognition task performed before and after the treatment with the drugs. Results: The control group, the VLX group, and the VLX and CPH group examined the object at the new location significantly more than the old one (P=0.04, P=0.05, and P=0.01, respectively). The test demonstrated a significant difference between Ki-67-positive cell numbers across the four groups (p < 0.0001). There was a significant decrease in the total number of Ki67-positive cells in the CPH group compared to the control group (p < 0.001). Conversely, the combined CPH and VLX group showed increased hippocampal proliferation compared to the CPH group (p < 0.001). There was a significant difference between GPX-1 positively stained cell numbers between control and CPH as well as control and CPH+VLX treated cells (p < 0.001) for both. Conclusion: our results show that CPH treatment caused cognitive deficits which were associated with a reduction in cell proliferation in dentate gyrus. These deficits were reduced when VLX was administered along with CPH.
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ElBeltagy, M., AlZoubi, L., AbuAnzeh, R. B., Yousef, M., AlAdwan, Y., AlZoubi, R., & Salman, A. (2024). The effect of Venlafaxine on the neuro-behavioral status of mice after administration of chemotherapeutic-neurotoxic agent (Cyclophosphamide). Pharmacy Practice, 22(4), 3039. https://doi.org/10.18549/PharmPract.2024.4.3039