Analysis and improvement measures of rational use of proton pump inhibitors for injection by clinical pharmacists

ABSTRACT

Objective: To analyze the irrational use of proton pump inhibitors for injection in clinic and its causes, and to promote the standardized use of proton pump inhibitors in hospital by clinical pharmacists by taking corresponding intervention measures. Methods: The use of proton pump inhibitors from January to March 2024 was collected through the rational drug use system of The Second Affiliated Hospital of Xuzhou Medical University, and the problems of irrational drug use during the use of proton pump inhibitors were classified, statistically summarized. Results: From January to March 2024, a total of 2363 inpatients in The Second Affiliated Hospital of Xuzhou Medical University were prescribed proton pump inhibitors for injection, including 1321 orders for esomeprazole for injection, 804 orders for omeprazole for injection, 166 orders for iprrazole for injection, 64 orders for Pantoprazole for injection, and 8 orders for rhaprazole for injection. There were 55 cases of unreasonable medical orders for drug use, and the irrational types of clinical drug use mainly included 24 unsuitable indications (43.64% of unreasonable medical orders). The selected drugs were not suitable in 7 cases (unreasonable medical advice accounted for 12.73%); Inappropriate usage and dosage in 19 cases (34.55%); There were 3 cases (5.45%) of unreasonable combination and 2 cases (3.64%) of unreasonable repeated administration. Conclusion: There are many unreasonable situations in the use of proton pump inhibitors for injection in our hospital. Clinical pharmacists will be committed to promoting hospitals to introduce a number of initiatives to standardize the use of proton pump inhibitors and improve the level of rational use of proton pump inhibitors.

KEYWORDS

• Proton pump inhibitors for injection
• Clinical pharmacist
• Rational drug use
• Omeprazole
• Esomeprazole

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• DOI10.18549/PharmPract.2025.2.3137Copy

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