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Pharmacological effects and bio-active compounds of Plantago major

Baiken Baimakhanova1, Amankeldi Sadanov1, Saltanat Orasymbet2, Alma Amangeldi4, Irina Smirnova3, Gul Baimakhanova3, Lyudmila Trenozhnikova3, Irina Ratnikova2, Jamilya Assilbayeva5, Zhanat Toxanbayeva6, Aigul Ibragimova6, Klara Zhumalina7, Rabiga Anarbayeva8, Nesipkul Asylova8, Zhanar Nurgaliyeva9, Aknur Turgumbayeva10★★ Corresponding author

  1. 1Research and Production Center for Microbiology and Virology, Almaty, Kazakhstan.
  2. 2Department of microbial preparations, Research and Production Center for Microbiology and Virology, Almaty, Kazakhstan.
  3. 3Department of Ecological and Agricultural Microbiology, Research and Production Center for Microbiology and Virology, Almaty, Kazakhstan.
  4. 4Department of food microbiology, Research and Production Center for Microbiology and Virology, Almaty, Kazakhstan.
  5. 5Department of Pharmaceutical Disciplines, Astana Medical University, Astana, Kazakhstan.
  6. 6Department of Pharmacology, Pharmacotherapy and Clinical Pharmacology, South Kazakhstan Medical Academy, Shymkent, Republic of Kazakhstan.
  7. 7Department of Pharmacy, Kazakh-Russian Medical University, Almaty, Kazakhstan.
  8. 8Department of Drug Technology, South Kazakhstan Medical Academy, Shymkent, Republic of Kazakhstan.
  9. 9School of Pediatrics, S.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
  10. 10Department of Fundamental Medicine, al-Farabi Kazakh National University, Almaty, Kazakhstan.

CORRESPONDENCE

Aknur Turgumbayeva

PhD, ass. Professor, Department of Fundamental Medicine, al-Farabi Kazakh National University, Almaty, Kazakhstan.

turgumbayeva.aknur@med-kaznu.com

Received: 23-05-2024; Accepted: 19-07-2024.

Volume 23, Issue 2 · pp. 3160 · PUBLISHED 21 May 2025 · DOI: 10.18549/PharmPract.2025.2.3160

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ABSTRACT

The purpose of this review is to provide a comprehensive overview of the research conducted on the chemical constituents and biological characteristics of Plantago major, Plantaginaceae. Methods: A comprehensive search of scientific databases, including Google, Google Scholar, PubMed, Science Direct, Researchgate and other online collections were extensively utilized. For efficient re-trieval, specific keywords like "Plantaginaceae", "Plantago major bio-active compounds", "Plantago major. phyto-chemicals", "Plantago major L. pharmacological activities", and "Plantago major'' traditional uses". Results: The medicinal benefits of herbal plants are recognized worldwide, and numerous scientific studies have been conducted to validate their effectiveness. Additionally, the emergence of drug-resistant microorganisms in recent years has prompted researchers to investigate the effects of medicinal plants on these pathogens. Plantago major one a such plant the healing properties have been acknowledged worldwide for numerous years. This particular plant contains various potent chemical compounds, including alkaloids, terpenoids, flavonoids, fatty acids, polysaccharides, vitamins, phenolic acid derivatives, and iridoid glycosides. These constituents contribute to its therapeutic effects and its wide range of medicinal qualities, such as antioxidant, antibacterial, anti-inflammatory, anti-diabetic, anti-cancer, and anti-ulcer properties. The main objective of this review is to highlight the potential use of Plantago major extracts as herbal remedies and explore their extensive therapeutic capabilities. Conclusion: Plantago major plays a significant role in the treatment of various diseases and specific health conditions, including diarrhoea, ulcers, bacterial infections, inflammation, and cancer. Research has demonstrated that this plant contains multiple classes of essential bioactive compounds, such as alkaloids, flavonoids, fatty acids, vitamins, iridoid glycosides, terpenoids, and phenolic compounds like caffeic acid. The therapeutic properties and biological activity of Plantago major are largely attributed to these active chemical components. However, further research is needed to fully understand the precise mechanisms and activities of the primary bioactive compounds responsible for treating specific diseases.

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    Baimakhanova, B., Sadanov, A., Orasymbet, S., Amangeldi, A., Smirnova, I., Baimakhanova, G., Trenozhnikova, L., Ratnikova, I., Assilbayeva, J., Toxanbayeva, Z., Ibragimova, A., Zhumalina, K., Anarbayeva, R., Asylova, N., Nurgaliyeva, Z., & Turgumbayeva, A. (2025). Pharmacological effects and bio-active compounds of Plantago major. Pharmacy Practice, 23(2), 3160. https://doi.org/10.18549/PharmPract.2025.2.3160