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Review

Recent Development in the Structural Modifications of Monocarbonyl Analogues of Curcumin and their Improved Biological Activities: A Review

Nidhi Negi1, Garima Chand1, Deepa Kholia1, Rahul Anand2, Santosh Kumar Upadhyay2, Geeta Tewari1, Penny Joshi1★★ Corresponding author

  1. 1Department of Chemistry, DSB Campus, Kumaun University, Nainital, Uttarakhand, INDIA.
  2. 2Department of Biotechnology, Bhimtal Campus, Kumaun University, Nainital, Uttarakhand, INDIA.

CORRESPONDENCE

Penny Joshi

Department of Chemistry, DSB Campus, Kumaun University, Nainital, Uttarakhand, INDIA.

dr.pennyjoshi@gmail.com

Received: 08-09-2023; Revised: 10-10-2023; Accepted: 17-10-2023.

Volume 17, Issue 34 · pp. 247–254 · PUBLISHED · DOI: 10.5530/phrev.2023.17.4

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ABSTRACT

Curcumin is a polyphenolic constituent of the rhizome of Curcuma longa and is known for its versatile biological properties like antioxidant, anti-bacterial, anti-cancer, anti-inflammatory, antiviral and so forth. Despite possessing a wide range of reported pharmacological effects, its clinical applicability is restricted, because of the poor bioavailability and poor solubility due to the presence of β-diketone moiety in its structure. Several strategies have been developed in the past decade to overcome this disadvantage. One important approach is designing and synthesizing new curcumin derivatives which have improved therapeutic properties and bioavailability than curcumin. Therefore, Monocarbonyl Analogues of Curcumin (MACs) have been synthesized with improved physiological properties and pharmacological effects. There is also a continued interest in synthesizing analogues that should have almost identical safety profiles like curcumin, but increased activity with enhanced oral bioavailability. This review describes the recent development in the structure modification of MACs and focuses on their anti-oxidant, antibacterial, anticancer activities and other biological activities.

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    Negi, N., Chand, G., Kholia, D., Anand, R., Upadhyay, S. K., Tewari, G., & Joshi, P. (). Recent Development in the Structural Modifications of Monocarbonyl Analogues of Curcumin and their Improved Biological Activities: A Review. Pharmacognosy Reviews, 17(34), 247–254. https://doi.org/10.5530/phrev.2023.17.4