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Targeting Tumor Growth and Progression in Carcinoma Prevention through Natural Catechol as Chemo Preventive Agents

Siddhant Krishna1, Sandip Chatterjee2★, Pawan Kumar Goswami3★ Corresponding author

  1. 1Department of Pharmacology, Narayan Institute of Pharmacy, Gopal Narayan Singh University, Sasaram, Bihar, INDIA.
  2. 2Department of Pharmacognosy, SRM Modinagar College of Pharmacy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, Delhi NCR campus, Ghaziabad, Uttar Pradesh, INDIA.
  3. 3Department of Pharmaceutical Analysis, Narayan Institute of Pharmacy, Gopal Narayan Singh University, Sasaram, Bihar, INDIA.

CORRESPONDENCE

Sandip Chatterjee

Department of Pharmacognosy, SRM Modinagar College of Pharmacy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, Delhi NCR campus, Ghaziabad, Uttar Pradesh, INDIA.

sandipkarna1994@gmail.com

Received: 03-12-2025; Revised: 15-01-2026; Accepted: 24-02-2026.

Volume 20, Issue 39 · pp. 54–62 · PUBLISHED · DOI: 10.5530/phrev.20260028

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ABSTRACT

Green tea is rich in catechins, which are polyphenolic chemicals that have strong anticancer effects through pro-apoptotic, anti-inflammatory, and antioxidant processes. They alter a number of molecular pathways, including as those that control the course of the cell cycle, limit angiogenesis, and reduce metastasis. With traditional Chemotherapeutics, Epigallocatechin Gallate (EGCG), the most researched catechin, exhibits synergistic actions that increase efficacy and decrease toxicity. Catechins may serve as both preventive and therapeutic agents in the treatment of carcinoma, according to data from in vitro, in vivo, and a small number of clinical investigations. However, issues like poor absorption and varying patient reactions call for sophisticated administration methods and extensive clinical testing.

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    Krishna, S., Chatterjee, S., & Goswami, P. K. (). Targeting Tumor Growth and Progression in Carcinoma Prevention through Natural Catechol as Chemo Preventive Agents. Pharmacognosy Reviews, 20(39), 54–62. https://doi.org/10.5530/phrev.20260028