Plants and phytochemicals for Huntington’s disease
Sunayna Choudhary1, Puneet Kumar2, Jai Malik1★★ Corresponding author
- 1Departments of Pharmacognosy.
- 2Pharmacology, ISF College of Pharmacy, Moga, Punjab, INDIA.
Received: 02-04-2013; Revised: 05-04-2013; Accepted: 25-04-2013.
Volume 7, Issue 14 · pp. 81–91 · PUBLISHED 7 May 2013 · DOI: 10.4103/0973-7847.120505
ABSTRACT
Huntington’s disease (HD) is a neurodegenerative disorder characterized by progressive motor dysfunction, including chorea and dystonia, emotional disturbances, memory, and weight loss. The medium spiny neurons of striatum and cortex are mainly effected in HD. Various hypotheses, including molecular genetics, oxidative stress, excitotoxicity, metabolic dysfunction, and mitochondrial impairment have been proposed to explain the pathogenesis of neuronal dysfunction and cell death. Despite no treatment is available to fully stop the progression of the disease, there are treatments available to help control the chorea. The present review deals with brief pathophysiology of the disease, plants and phytochemicals that have shown beneficial effects against HD like symptoms. The literature for the current review was collected using various databases such as Science direct, Pubmed, Scopus, Sci‑finder, Google Scholar, and Cochrane database with a defined search strategy.
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Choudhary, S., Kumar, P., & Malik, J. (2013). Plants and phytochemicals for Huntington’s disease. Pharmacognosy Reviews, 7(14), 81–91. https://doi.org/10.4103/0973-7847.120505