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Asian Journal of Biological and Life sciencesNOW IN
Article

A Comparative Study on the in vitro Cytotoxicity and Anti-Cancer Properties of Gold Nanoparticles Derived from Elettaria cardamomum

Sowmya Kizheka Meladom1, Ramasamy Thanghavelu Narendhirakannan1★★ Corresponding author

  1. 1Department of Biochemistry, Kongunadu Arts and Science College (Autonomous), G.N. Mills P.O, Coimbatore, Tamil Nadu, INDIA.

CORRESPONDENCE

Ramasamy Thanghavelu Narendhirakannan

Department of Biochemistry, Kongunadu Arts and Science College (Autonomous), G.N. Mills P.O, Coimbatore, Tamil Nadu, INDIA.

rtnaren@kongunaducollege.ac.in

Received: 15-01-2024; Revised: 14-03-2024; Accepted: 21-04-2024.

Volume 13, Issue 1 · pp. 100–108 · PUBLISHED · DOI: 10.5530/ajbls.2024.13.14

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ABSTRACT

Aim: This study scrutinizes the anti-cancer potential of gold nanoparticles derived from Elettaria cardamomum pods and seeds. Materials and Methods:The biosynthesized nanoparticles underwent thorough characterization via UV Vis, FTIR, SEM and EDX analyses. Utilizing the MTT assay, cytotoxicity and anti-cancer efficacy against L929 (normal fibroblast) and Colon cancer cell lines (HT-29 and SW480) cell lines were assessed. Results: Notably, the IC50 values for pod and seed-based nanoparticles were determined as 156.12 μg/mL and 48.771 μg/mL, respectively, against L929 cells. Strikingly, Elettaria cardamomum pod-based nanoparticles demonstrated superior anti-cancer potential against HT-29 and SW480 cell lines compared to seed-based counterparts. Conclusion: Therefore, this study suggests the potential therapeutic utility of greensynthesized gold nanoparticles from Elettaria cardamomum pods as an innovative approach for treating colorectal cancer. Anti-cancer Colorectal cancer cytotoxicity Elettaria cardamomum Gold nanoparticles

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    Meladom, S. K., & Narendhirakannan, R. T. (). A Comparative Study on the in vitro Cytotoxicity and Anti-Cancer Properties of Gold Nanoparticles Derived from Elettaria cardamomum. Asian Journal of Biological and Life sciences, 13(1), 100–108. https://doi.org/10.5530/ajbls.2024.13.14