Effective Use of BV-AVD Regimen in The Management of Classical Hodgkin Lymphoma: A Case-Based Approach
Shirly Sasikumar1, Mathesh Anandan1, Darius Alan1, Dhivya Kothandan1★★ Corresponding author
- 1Department of Pharmacy Practice, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai, Tamil Nadu, INDIA.
CORRESPONDENCE
Dhivya Kothandan
Department of Pharmacy Practice, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai, Tamil Nadu, INDIA.
Received: 25-04-2025; Revised: 09-06-2025; Accepted: 18-08-2025.
Volume 19, Issue 1 · pp. 120–122 · PUBLISHED · DOI: 10.5530/ijopp.20260387
ABSTRACT
Classical Hodgkin Lymphoma (CHL) is a malignant lymphoproliferative disorder characterized by the presence of Reed-Sternberg cells(R-SC), which are large, multinucleated cells within an inflammatory microenvironment of immune cells, fibrosis, and necrosis. While its exact cause remains unclear, CHL is strongly associated with Epstein-Barr Virus (EBV) infection, genetic factors, and immune dysregulation. Common symptoms include fever, night sweats, unexplained weight loss, pruritus, fatigue, and hepatosplenomegaly. This report presents a rare case of CHL of mixed cellularity in a 35-year-old pregnant woman, who was admitted with generalized pruritus, joint pain, and bilateral upper lymphadenopathy. The diagnosis was confirmed through a PET-CT scan, bone marrow biopsy, and lymph node excision biopsy. The patient was initiated on cycle 1B chemotherapy with adriamycin, vinblastine, dacarbazine, and Brentuximab Vedotin (BV-AVD), along with supportive care and lifestyle modifications to ensure optimal maternal and fetal outcomes.
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Sasikumar, S., Anandan, M., Alan, D., & Kothandan, D. (). Effective Use of BV-AVD Regimen in The Management of Classical Hodgkin Lymphoma: A Case-Based Approach. Indian Journal of Pharmacy Practice, 19(1), 120–122. https://doi.org/10.5530/ijopp.20260387