A New Kinetic Approach. Stability of Cefquinome Sulfate under Variable pH and Temperature
Mengjiao Liu1, Qiang Fu1, Hualin Fu1★, Gang Shu1, Wei Zhang1, Fengying Deng1, Jun Hu1★ Corresponding author
- 1Department of Pharmacy, College of Veterinary Medicine, Sichuan Agriculture University, Ya, an, Sichuan-625014, China.
CORRESPONDENCE
Hualin Fu
Department of Pharmacy, College of Veterinary Medicine, Sichuan Agriculture University, Ya, an, Sichuan-625014, China.
Received: 13-03-2013; Revised: 17-09-2014; Accepted: 06-11-2014.
Volume 48, Issue 4S · pp. s27–s33 · PUBLISHED 2014 · DOI: 10.5530/ijper.48.4s.4
ABSTRACT
Object:This study was evaluation of Cefquinome Sulfate (CS) long-term stability under different conditions of pH and temperature, so as to suggest the best conditions to perform its clinical application. Method: The CS stability was investigated at different values of pH (2.0-9.0) and temperature (4-370C). Kinetic parameters of CS degradation in alkaline environment were calculated adopting a new model that took into consideration the equilibrium between the active and a reversibly inactivated form of CS after long-time degradation. Result: All temperatures show increased CS instability,and this effect decreased in following sequence: 370C>250C>150C>40C, which describe typical Arrhenius behaviors with good correlation for Kd(R2= 0.941). Conclusion: The alkali-catalyzed degradation of CS was faster and stronger than the acidic one. The best conditions were met at a pH6.8 and 40C .
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Liu, M., Fu, Q., Fu, H., Shu, G., Zhang, W., Deng, F., & Hu, J. (2014). A New Kinetic Approach. Stability of Cefquinome Sulfate under Variable pH and Temperature. Indian Journal of Pharmaceutical Education and Research, 48(4S), s27–s33. https://doi.org/10.5530/ijper.48.4s.4