Volume 48, Issue 4S

Pharmaceutical Research

1. Article

   Screening of Mandarin Oil on Indomethcin Induced Inflammatory Bowel Disease in Wistar Rats

   Nitin R Patil, Vijaykumar P Rasal, Rohit Hanumantrao Malabade

   pp. s1–s6 · DOI: 10.5530/ijper.48.4s.1 · Published 2014

   Objective: The present study investigates the protective effect of Mandarin Oil against Indomethacin (INDO) induced Inflammatory Bowel Disease (IBD) in male Wistar rats. Material and Method: IBD was induced by administra…

2. Article

   Formulation and In-vitro Evaluation of Sublingual Tablets of Ondansetron Hydrochloride using Coprocessed Excipients

   Ajeet M. Godbole, Sandesh N. Somnache, Shalin P. Thakker, Sudhir R Iliger, Ashwini S. Joshi, Bhautik V. Patel

   pp. s7–s17 · DOI: 10.5530/ijper.48.4s.2 · Published 2014

   The formulation of sublingual tablets of Ondansetron HCl was carried out by using direct compression technique and evaluation tests were carried out as per pharmacopoeial specifications. Poor compressibility problem of M…

3. Article

   Formulation and Evaluation of Losartan Potassium Osmotic Controlled Matrix Tablets

   Vidyadhara Suryadevara, Sasidhar Reddyvalam Lankapalli, Uma Maheswar Rao Vejella, Sundeep Mupparaju and Showri babu Chava

   pp. s18–s26 · DOI: 10.5530/ijper.48.4s.3 · Published 2014

   Osmotically controlled oral drug delivery systems utilize osmotic pressure as energy source for the controlled delivery of drugs, independent of pH and hydrodynamic conditions of gastro intestinal tract (GIT). The presen…

4. Article

   A New Kinetic Approach. Stability of Cefquinome Sulfate under Variable pH and Temperature

   Mengjiao Liu, Qiang Fu, Hualin Fu, Gang Shu, Wei Zhang, Fengying Deng, Jun Hu

   pp. s27–s33 · DOI: 10.5530/ijper.48.4s.4 · Published 2014

   Object:This study was evaluation of Cefquinome Sulfate (CS) long-term stability under different conditions of pH and temperature, so as to suggest the best conditions to perform its clinical application. Method: The CS s…

5. Article

   Formulation Development and Evaluation of Fast Disintegrating Tablets of Ambroxol Hydrochloride for Pediatrics- A Novel Approach for Drug Delivery

   Deepak Sharma, Mankaran Singh, Dinesh Kumar, Gurmeet Singh, Mahendra Singh Rathore

   pp. s40–s48 · DOI: 10.5530/ijper.48.4s.6 · Published 2014

   Objective: The objective of the present study was to prepare the fast disintegrating tablet of Ambroxol Hydrochloride for respiratory disorders such as bronchitis, asthma and cough for pediatrics. Material and Methods: T…

6. Article

   Diclofenac Sodium Loaded Sustained Release Matrix Tablet Possessing Natural and Synthetic Polymers: Formulation and in vitro Characterization

   Upendra Nagaich, Charu Bharti, Ashok Kumar Pal, Neha Gulati.

   pp. s49–s55 · DOI: 10.5530/ijper.48.4s.7 · Published 2014

   Object:The objective of the present study was to investigate the effect of various concentrations of natural and synthetic polymers on in vitro drug release from sustained release matrix tablets. Materials and method: HP…

7. Article

   Study of block copolymer micelles as vehicles for hydrophobic drug Lamotrigine

   Shilpa Praveen Chaudhari, Jayashree Ramesh Patil.

   pp. s56–s66 · DOI: 10.5530/ijper.48.4s.8 · Published 2014

   Objective: The objective of the study was to investigate the solubilization of poorly water-soluble drug Lamotrigine in pure & mixed Pluronic polymeric micelles. Method: Two different Pluronic (Pluronic F68, Pluronic L81…

8. Article

   Fast Dissolving Sublingual Films of Zolmitriptan : A Novel treatment approach for Migraine Attacks

   Prachi Pandey, Sonam Chauhan

   pp. s67–s72 · DOI: 10.5530/ijper.48.4s.9 · Published 2014

   Zolmitriptan, 5- Hydroxy tryptamine agonist is a new generation anti-migraine drug showing the oral bioavailability of only 40% as a result of hepatic first pass metabolism. The present research work is aimed to prepare …

9. Article

   New liquid chromatographic method for simultaneous quantification of Atovaquone and Proguanil with its active metabolite Cycloguanil in human plasma

   Naresh Bejugam, Swapnil J Dengale, Raghavendra Shetty and Prashant B Musmade

   pp. s83–s92 · DOI: 10.5530/ijper.48.4s.11 · Published 2014

   Objective: The aim of the present study is to develop HPLC method for simultaneousquantification of atovaquone and proguanil with its active metabolite cycloguanilin human plasma. Methodology: A specific and accurate hig…

10. Article

    Taste Masked Quinine Sulphate Loaded Solid Lipid Nanoparticles for Flexible Pediatric Dosing

    Panchaxari Mallappa Dandagi, Seeprarani Prabirkumar Rath, Anand Panchakshari Gadad, Vinayak Shivamurthi Mastiholimath

    pp. s93–s99 · DOI: 10.5530/ijper.48.4s.12 · Published 2014

    Introduction: Quinine Sulphate is an antimalarial agent usually indicated in the treatment of chloroquine resistant malaria. Objective: The objective of the present investigation was to prepare quinine sulphate loaded so…

11. Article

    Formulation and Evaluation of Floating Microcapsules of Cefpodoxime Proxetil

    Monica RP Rao, Aafaque Yunusi, Swapnil Shelar

    pp. s100–s108 · DOI: 10.5530/ijper.48.4s.13 · Published 2014

    Introduction: Floating drug delivery system is widely used technique to obtain higher bioavailability for drugs which have an absorption window in the stomach. Floating microcapsule is one approach to improve gastroreten…

12. Article

    Formulation and Development of Fixed Dose Combination of Antihypertensive and Antidiabetic Agent for treatment of Co-existent Type Two Diabetes Mellitus and Hypertension

    Nisharani Ranpise, Preeti Jamkar, Harshada Langote

    pp. s109–s117 · DOI: 10.5530/ijper.48.4s.14 · Published 2014

    Objective: Coexistent Type Two Diabetes Mellitus (TTDM) and hypertension exposes patients to severe co-morbidities. Complex polypharmacy suggested by international organizations leads to the increased pill burden and dec…

13. Article

    Design and Characterization of Gastroretentive Bilayer Tablet of Amoxicillin Trihydrate and Ranitidine Hydrochloride for H. pylori Infection

    Shikha Jain, Vikas Jain, S.C. Mahajan

    pp. s118–s131 · DOI: 10.5530/ijper.48.4s.15 · Published 2014

    Objective:The present study was aimed at developing Gastroretentive Bilayer drug delivery systems containing Amoxicillin Trihydrate and Ranitidine Hydrochloride for the treatment of H. pylori induced peptic ulcer to mini…

14. Article

    Effect of Extractive Phytoconstituents of Limonia acidissma Linn. and their probable mechanism against Phenothiazine Induced Extra Pyramidal Side Effects

    Rajnish Srivastava, Chandel H.S., Nagar Hemant, Sexena Rajiv, Deepa Deepa

    pp. s132–s138 · DOI: 10.5530/ijper.48.4s.16 · Published 2014

    Aim: The present study investigated the preventive effect and probable mechanism of ethanolic extract of Limonia acidissima (EELA) stem bark as compared to standard (L-dopa) in phenothiazine induced extra pyramidal side …

15. Article

    Antipsoriatic and Inhibitory effects of an oral dosage form containing Bioflavonoids on inflammatory cytokines IL-1α, IL-1β, IL-6, IL-8, IL-17 and TNF-α

    A Vijayalakshmia, V Ravichandiran, K Masilamani

    pp. s139–s148 · DOI: 10.5530/ijper.48.4s.17 · Published 2014

    Objective: The present study aimed to develop and evaluate orally administrable dosage form containing bioactive flavonoids viz., Luteolin-7-O-β-D-Glucuronide (II), Kaempferol 3-O-[2-O-(6-O-feruloyl)-β-D-glucopyranosyl]-…