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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Quality Standardization and Nephroprotective Effect of Garcinia pedunculata Roxb. Fruit rind

Ravi Mundugaru1, Senthil Kumar Sivanesan2, Padmaja Udaykumar3, Febin Joy4, Sunil Kumar Koppala Narayana5★, Lekshmi Rajakrishnan6, Al Farhan Ahmed Abdullah Bin Hamad7, Thomas Jacob7, Rajakrishnan Rajagopal7, Sameh Mohammed Hisham7★ Corresponding author

  1. 1Department of Pharmacology, SDM Centre for Research in Ayurveda and Allied Sciences, Udupi, INDIA.
  2. 2Department of Research and Development, Saveetha University, Thandalam, Chennai, INDIA.
  3. 3Department of Pharmacology, Father Muller Medical College, Mangalore, INDIA.
  4. 4Department of Dravyaguna, Muniyal Institute of Ayurveda Medical Sciences, Manipal, INDIA.
  5. 5Department of Pharmacognosy, SDM Centre for Research in Ayurveda and Allied Sciences, Udupi, INDIA. Current: Department of Pharmacognosy, Siddha Central Research Institute, Arumbakkam, Chennai, INDIA.
  6. 6Department of Botany and Biotechnology, MSM College, Kayamkulam, Kerala, INDIA.
  7. 7Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, SAUDI ARABIA.

CORRESPONDENCE

Sunil Kumar Koppala Narayana

Department of Pharmacognosy, SDM Centre for Research in Ayurveda and Allied Sciences, Udupi, INDIA. Current: Department of Pharmacognosy, Siddha Central Research Institute, Arumbakkam, Chennai, INDIA.

sunilkumarnarayanan@gmail.com

Received: 30-11-2016; Revised: 31-03-2017; Accepted: 13-07-2017.

Volume 51, Issue 4 · pp. 713–721 · PUBLISHED 2017 · DOI: 10.5530/ijper.51.4.105

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ABSTRACT

Fruit rind of Garcinia pedunculata is one of the important medicinal plant and a condiment used in Indian kitchen. In spite of many medicinal properties ascribed to this species, less of pharmacological studies are carried out on this species. The objective of present study was to determine the quality standards of the fruit rind followed by evaluation of nephroprotective activity of aqueous extract in cisplatin induced nephrotoxicity. Macromicroscopic, physico-chemical, preliminary phytochemical and HPTLC studies were carried out following pharmacopoeial procedures. On 7th days an hour after treatment with group specific drugs, cisplatin 20mg/kg was injected intraperitonially to all groups except normal control mice. Nephrotoxicity was assessed by serum biochemical, antioxidant and histological changes in kidney after 72h of cisplatin injection. Pharmacopoeial tests revealed authenticity and quality indicating standards for the fruit rind. Single intraperitonial injection of cisplatin significantly elevated serum urea, creatinine and lipid peroxidation in kidney tissue compared to the control group. The drug has exhibited necrotic changes in the tubular epithelium, edematous changes in the interstitial tissue and focal cell infiltration. These changes were significantly reduced with AFGP administration and considerably reversed the histological changes caused by cisplatin injection.

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    Mundugaru, R., Sivanesan, S. K., Udaykumar, P., Joy, F., Narayana, S. K. K., Rajakrishnan, L., Hamad, A. F. A. A. B., Jacob, T., Rajagopal, R., & Hisham, S. M. (2017). Quality Standardization and Nephroprotective Effect of Garcinia pedunculata Roxb. Fruit rind. Indian Journal of Pharmaceutical Education and Research, 51(4), 713–721. https://doi.org/10.5530/ijper.51.4.105