Volume 51, Issue 4

2017 · pp. 502–764 · 33 articles

Volume: 51
Issue: 4
Published: 2017
Pages: 502–764
Articles: 33
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Original Article Research Article

In this issue

Original Article

Article
Designing of Curriculum Aspects of Pharmacy Undergraduate Course in Respect of Graduate Employability
Shivaji P.Gawade, Nitin P.Sonaje
pp. 502–509 · DOI: 10.5530/ijper.51.4.78 · Published 2017
Objectives: Objective of the present research work was to enhance graduate employability based on the needs of pharmaceutical industries, to evaluate present undergraduate curriculum and to redefine it by conducting surv…
Article
Experience of Introduction of the Online Course in Biology for Pharmacy Students in Ukraine
FiliptsovaOlga FiliptsovaOlga, NabokaOlga NabokaOlga, Gazzavi-RogozinaLyudmila Gazzavi-RogozinaLyudmila, DyominaYevgeniya DyominaYevgeniya, GaliyLarisa GaliyLarisa
pp. 510–516 · DOI: 10.5530/ijper.51.4.79 · Published 2017
Introduction: Distance learning is getting more and more popular all over the world and more recently it expanded into Ukraine. The objective of work was to clarify the experience of development and principles of the on-…
Article
Preparation and Evaluation of Matrix Type Transdermal Patches of Domperidone Maleate: in vitro and ex vivo Characterization
Suddala Shirisha, Gomathi Joshi, Sunit Kumar Sahoo, Yamsani Madhusudan Rao
pp. 517–524 · DOI: 10.5530/ijper.51.4.80 · Published 2017
Objective: Domperidone Maleate is a dopamine - receptor (D2) antagonist, widely used in the treatment of motion sickness and used as an antiemetic. The bioavailability of domperidone maleate when administered orally is l…
Article
Formulation and Characterization of Tapentadol Loaded Emulgel for Topical Application
Nitin Prabhakar Ambhore, Panchaxari Mallapa Dandagi, Anand Panchaxari Gadad, Paresh Mandora
pp. 525–534 · DOI: 10.5530/ijper.51.4.81 · Published 2017
Background: Tapentadol is a centrally acting analgesic drug which falls under class III drug as per biopharmaceutical classification systems having poor bioavailability. Aim: Therefore, present study was aimed at solubil…
Article
Development and Characterization of Fast Dissolving Oral Films of Orciprenaline Sulphate
Saili Mahadev Prabhudessai, Panchaxari Mallappa Dandagi, Yashaswini Lakshman, Anand Panchakshari Gadad
pp. 536–542 · DOI: 10.5530/ijper.51.4.82 · Published 2017
Introduction: From past few decades there has been a massive change in designing various drug delivery systems to achieve rapid onset of action to treat sudden surprising disorders like hypertensive reactions. Fast disso…
Article
β-Cyclodextrin-g-Poly (2-(dimethylamino) ethyl methacrylate) as the Stabilizer and Reductant to Prepare Colloid Silver Nanoparticles in situ
Jianhua Zhou, Xianghua Zha, Xin Chen, Jianzhong Ma
pp. 543–550 · DOI: 10.5530/ijper.51.4.83 · Published 2017
Background: The preparation of silver nanoparticles often involves some tedious steps and extra reducing agents. PDMAEMA and β-CD can act as the reducing and stabilizing agents for the preparation of silver nanoparticles…
Article
Development and Evaluation of a System for Colonic Delivery of Budesonide
Nikita Maruti Gaikwad, Karimunnisa Sameer Shaikh, Pravin Digambar Chaudhari
pp. 551–561 · DOI: 10.5530/ijper.51.4.84 · Published 2017
In the present study an attempt has been made to address low solubility issue and colonic delivery of Budesonide by developing enteric coated capsule containing Budesonide in a nano emulsifying drug delivery system. Here…
Article
Solid Dispersion of Nateglinide in Polyoxy Ethylene-Polyoxy Propylene Block Copolymer: in vitro and in vivo Evaluation
Ranjit Prasad Swain, Bharat Bhusan Subudhi
pp. 562–570 · DOI: 10.5530/ijper.51.4.85 · Published 2017
Objective: The study was aimed to improve solubility and bioavailability of nateglinide preparing stable solid dispersions with polyoxy ethylene-polyoxy propylene block copolymer (poloxamer 188). Methods: The solid dispe…
Article
Poly(lactic acid-co-glycolic acid) Nanospheres Improved the Oral Delivery of Candesartan Cilexetil
Anroop B Nair, Bandar E Al-Dhubiab, Jigar Shah, Mahesh Attimarad, Sree Harsha
pp. 571–579 · DOI: 10.5530/ijper.51.4.86 · Published 2017
Purpose: Certain physicochemical characteristics of Candesartan Cilexetil (CC) lead to incomplete oral absorption and poor clinical efficacy. This study assessed the prospect of the use of drug-embedded nanospheres to au…
Article
Micellar Properties and Antimicrobial Activityof a Mixed Surfactant System Constituted by Sodium Dodecyl Sulfate and Cetylpyridinium Chloride
Deniz Şahin Taş, Servet Çete
pp. 580–587 · DOI: 10.5530/ijper.51.4.87 · Published 2017
Objective: Micellar properties of sodium dodecyl sulfate (NaDS) was examined in the presence of cetylpyridinium chloride (CPC) by means of surface tension, viscosity, dye solubilization, cloud point (CP) measurements.Ant…
Article
Gamma Amino Butyric Acid Ameliorates Jejunal Oxidative Damage in Diabetic Rats
Noaman Eltahawy, Amr Abd El-Hady, Manal Badawi, Ahmed Hammad
pp. 588–596 · DOI: 10.5530/ijper.51.4.88 · Published 2017
Introduction: The small intestine exhibits morphological and functional changes in streptozotocin (STZ)-induced diabetes. This study was carried out to clarify the role of gamma-aminobutyric acid (GABA) in ameliorating t…
Article
Silibinin: An Inhibitor of Mir-181a Gene Expression in Sk-Br-3 Breast Cancer Cell Line
Parvaneh Shahinfar, Nasrin Motamed, Elnaz Birjandian, Omid Shabanpour
pp. 597–602 · DOI: 10.5530/ijper.51.4.89 · Published 2017
Background: Mir-181a has been considered as an attractive molecular target for breast cancer therapy. The main objective of this work is to assess the inhibitory effects of silibinin, a herbal substance, on proliferation…
Article
An Evaluation of Antioxidant Potential of Flavonoid Eriodictyol in Isoproterenol-Induced Myocardial Infarction in Rats
Preethi Hariharan, Mariyappan Palani, Manju Vaiyapuri
pp. 603–612 · DOI: 10.5530/ijper.51.4.90 · Published 2017
Aim: The study was designed to evaluate the antioxidant potential of eriodictyol on lipid peroxidation caused due to isoproterenol induced myocardial infarction in albino male wistar rats. Methods: Myocardial Infarction …
Article
Simultaneous Determination of Linezolid and Levamisole Hydrochloride in a Fixed Dose Combination
Lalit Kumar, Yugvijay Singh Yadav, Mahalaxmi Rathnanand
pp. 613–619 · DOI: 10.5530/ijper.51.4.91 · Published 2017
Background: The combination of antibiotics with an immune-stimulant can be used for the prevention of antimicrobial resistance. Multilayer tablets of linezolid and levamisole hydrochloride can be a solution of this probl…
Article
Determination of Tl(I) Ions in Homeopathic Drugs by Differential Pulse Anodic Stripping Voltammetry
Włodzimierz Zembrzuski, Bożena Karbowska
pp. 620–625 · DOI: 10.5530/ijper.51.4.92 · Published 2017
Objectives: The present study is focused on the determination of thallium (I) ions in homeopathic drugs. Methods: The determination was carried out using the Differential Pulse Anodic Stripping Voltammetry (DPASV) techni…
Article
Development and Validation of an Analytical Method for Related Substances in N-acetyl–L-cysteine Effervescent Tablets by RP-HPLC
Elizabeth Mary Mathew, Angadi Ravi, Nalawade Rameshwar, Moorkoth Sudheer, Bhat Krishnamurthy
pp. 626–635 · DOI: 10.5530/ijper.51.4.93 · Published 2017
Background: The reported chromatographic methods for N-acetyl cysteine [NAC] are reverse phase HPLC and ion pair chromatography [IPC] for related substances test in bulk and in formulations. No reported stability indicat…
Article
Determination on Vildagliptin in Rat Plasma by Capillary Electrophoresis Tandem Mass Spectrometry: It’s Application to Pharmacokinetic Study
Mahesh Attimarad, Sree Harsha Nagaraja, Bandar Essa Aldhubiab, Anroop Balachandran Nair, Katarigatta Narayanaswamy Venugopala
pp. 636–643 · DOI: 10.5530/ijper.51.4.94 · Published 2017
Background: Vildagliptin, a dipeptidyl peptidase-4 inhibitor, is one of the potent oral antidiabetic agent. Objective: The objective of the present work was to establish a rapid, sensitive and validated capillary electro…
Article
Novel RP-HPLC Method Development and Validation of Meloxicam Suppository
Sufiyan Ahmad, Sharma Deepika, Patil Amol, Warude Kapil, Md. Rageeb Md.Usman
pp. 644–649 · DOI: 10.5530/ijper.51.4.95 · Published 2017
Objective: A simple reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed and validated for simultaneous determination of Meloxicam drug (MLX) in pharmaceutical mixture. Methods: Effe…
Article
650 Indian Journal of Pharmaceutical Education and Research | Vol 51 | Issue 4 | Oct-Dec, 2017 Original Article www.ijper.org Synthesis, Characterization and Antibacterial Evaluation of Some Azole Derivatives
Manju Rani, Shivani Sharma, Rajani Chauhan, Swapnil Sharma, Jaya Dwivedi
pp. 650–655 · DOI: 10.5530/ijper.51.4.96 · Published 2017
Purpose: Tremendous rise in development of resistance to the antimicrobials has created alarming situation for researchers and clinicians. Method: In this regard, an attempt has been made to develop a series of azole der…
Article
Calprotectin Complex Interactions with Phytoquinolines and New Target Binding Alternates Calprotectin complex and Phytoquinolines
Muthukrishnan Suriyavathana, Meleveetil Vidhya
pp. 656–663 · DOI: 10.5530/ijper.51.4.97 · Published 2017
Objective: S100 proteins, the low molecular weight calcium binding proteins, have ‘EF hand’ type conformation. They are identified as markers for various diseases. A member of S100 protein family, S100A9 is involved, in …
Article
Ligand Based in-silico Study on Pyridopyrimidinedione Derivatives as Dipeptidyl Peptidase-IV Inhibitors
Ghode Piyush, Jain Sanmati Kumar
pp. 664–671 · DOI: 10.5530/ijper.51.4.98 · Published 2017
Background: Type-2 diabetes mellitus can be effectively treated with dipeptidyl peptidase- IV inhibitors. Diverse classes of molecules have exhibited promising DPP-IV inhibition. Objective: In this perspective, 3D-QSAR a…
Article
Biological Activities of Black Garlic Fermented with Lactobacillus plantarum PN05 and Some Kinds of Black Garlic Presenting Inside Vietnam
Nguyen Ngan, Mac Giang, Nguyen Tu
pp. 672–678 · DOI: 10.5530/ijper.51.4.99 · Published 2017
Background: Black garlic has become more popular in Vietnam due to its interesting biological activities. Purpose: The quality of different black garlic preparations should be checked. Methods: 1010 colony forming units …
Article
Formulation of an Emulgel Containing Strawberry Fruit Extract and in-vivo Evaluation for Different Skin Parameter
Rizwana Kausar, Naveed Akhtar
pp. 679–683 · DOI: 10.5530/ijper.51.4.100 · Published 2017
Introduction: It has been indicated from previous research that strawberry consumption may be beneficial to improve skin appearance and its extract has antioxidant and antiinflammatory effects. Objective: The aim of pres…
Article
Response Surface Methodology Optimization of Thebaine Biotransformation into Codeine and Morphine Using Bacillus sp. FAR
Nazanin Ataee, Jamshid Fooladi, Mohammad Hasan Namaei, Fateme Mirzajani
pp. 684–691 · DOI: 10.5530/ijper.51.4.101 · Published 2017
Background: Codeine and morphine are important pharmaceuticals having analgesic characteristics. Aim: The current study used response surface methodology to optimize the biotransformation of thebaine into codeine and mor…
Article
Evaluation of Unsaponified Petroleum Ether Extract of Lantana camara L. leaves for Antioxidant Activity and Oxidative Stability
Patil Shriniwas Pramod, Kumbhar Subhash Trimbakrao, Ambhore Vanita
pp. 692–699 · DOI: 10.5530/ijper.51.4.102 · Published 2017
Background: Lantana camara L. leaves have been traditionally claimed to be used in treatment of different illnesses. Leaves are rich in lower terpenes in the form of essential oil, however they also contain lipids like w…
Article
The Total Phenolic Contents and Antioxidant Activities of Endemic Species Ajuga postii Briq. and Ajuga relicta P.H.Davis (Lamiaceae) from Turkey
Emel Sönmez, Yavuz Bülent Köse
pp. 700–705 · DOI: 10.5530/ijper.51.4.103 · Published 2017
Background: Ajuga species are anthelmintic, diuretic, antifungal, and antimycobacterial agents.Lamiaceae members Ajuga postii Briq. and Ajuga relicta P.H.Davis are local endemic species of Turkey. Aim: To give informatio…
Article
Identification of Bioactive Compounds and Possible Mechanism of Hepatoprotective Activity of Ficus microcarpa l. Fil. Bark Extracts in Ethanol-Induced Chronic Hepatic Injury in Rats
Sanjay Javerilal Surana, Anilkumar Uttamchand Tatiya, Mohan Ganpatrao Kalaskar
pp. 706–712 · DOI: 10.5530/ijper.51.4.104 · Published 2017
Objective: To evaluate the effect of the successive extracts of the FMB on ethanol induced chronic hepatotoxicity. Furthermore, to understand the mechanisms of its pharmacological actions, the in vivo antioxidant activit…
Article
Quality Standardization and Nephroprotective Effect of Garcinia pedunculata Roxb. Fruit rind
Ravi Mundugaru, Senthil Kumar Sivanesan, Padmaja Udaykumar, Febin Joy, Sunil Kumar Koppala Narayana, Lekshmi Rajakrishnan, Al Farhan Ahmed Abdullah Bin Hamad, Thomas Jacob, Rajakrishnan Rajagopal, Sameh Mohammed Hisham
pp. 713–721 · DOI: 10.5530/ijper.51.4.105 · Published 2017
Fruit rind of Garcinia pedunculata is one of the important medicinal plant and a condiment used in Indian kitchen. In spite of many medicinal properties ascribed to this species, less of pharmacological studies are carri…
Article
Comparative Evaluation of in vitro Cellular Uptake and Antiproliferative Potential of Different Extracts of Orthosiphon pallidus Royle
Mukesh K. Singh, Hemant Dhongade, Dulal Krishna Tripathi
pp. 722–728 · DOI: 10.5530/ijper.51.4.106 · Published 2017
Objective: Evaluation of the cytotoxic effect of different extracts of Orthosiphon pallidus Royle on MCF-7 cell lines, comparatively. Materials and Methods: The breast cell line MCF-7 was cultured in DMEM medium containi…
Article
Attenuation of Oxidative Stress and Hepatotoxicity Induced By D–Galactosamine by a Polyherbal Formulation Ambrex–in vivo and in vitro Studies
Anila Raslin, Sekar Sathiya, Chidambaram Saravana Babu, Johanna Rajkumar
pp. 729–739 · DOI: 10.5530/ijper.51.4.107 · Published 2017
Objective: To evaluate the hepatoprotective effect of Ambrex, a polyherbal formulation against D–galactosamine (D-GLN) induced hepatotoxicity in Swiss albino mice as well as in Chang liver cell lines. Materials and Metho…
Article
A Study on Antimicrobial Evaluation of Newly Synthesized Antipyrin Analogues
Sahoo Jyotirmaya, Paidesetty Sudhir Kumar
pp. 740–747 · DOI: 10.5530/ijper.51.4.108 · Published 2017
The antipyrinyl derived molecules are a versatile building blocker organic compounds and used in medicinal drug research. A versatile range of hybrid molecules have been synthesized by diazotization of 4-aminoantipyrin a…
Article
Synthesis, Characterization, Antimicrobial, DNA cleavage, and Cytotoxicity Studies of Some Metal (II) Complexes of Tridentate Schiff Base Ligand: 2-hydroxy-3-((4-(4-phenylthiazol-2-yl) semicarbazide) methyl) Benzoic Acid
Shambuling Karabasannavar, Parvati R Allolli, Basavaraj M. Kalshetty
pp. 748–757 · DOI: 10.5530/ijper.51.4.109 · Published 2017
Objective: The main aim of the present work was to synthesize a novel Schiff base ligand 2-hydroxy-3-((4-(4-phenylthiazol-2-yl) semicarbazide) methyl) benzoic acid is obtained by the condensation of N-(4-phenylthiazole-2…

Research Article

Article
Development of Proniosomal Gel: in-vitro, ex-vivo and in-vivo Characterization
Nadeem Ahmed Farooqui, Mousumi Kar, Ravindra Pal Singh, Sanjay Jain
pp. 758–764 · DOI: 10.5530/ijper.51.4.110 · Published 2017
The aim of the present research work was to characterize the ex-vivo, in-vitro and in-vivo studies of proniosomal (PN) gel of ketorolac tromethamine (KT). Experimental work: Proniosomal suspension was prepared by rotator…