jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Solid Dispersion of Nateglinide in Polyoxy Ethylene-Polyoxy Propylene Block Copolymer: in vitro and in vivo Evaluation

Ranjit Prasad Swain1,2★, Bharat Bhusan Subudhi1★ Corresponding author

  1. 1Drug Development and Analysis Laboratory, School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar, Odisha, INDIA.
  2. 2Department of Pharmaceutical Technology, Maharajah’s College of Pharmacy, Vizianagaram, Andhra Pradesh, INDIA.

CORRESPONDENCE

Ranjit Prasad Swain

Drug Development and Analysis Laboratory, School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar, Odisha, INDIA.

ranjit.prasad797@gmail.com

Received: 15-02-2017; Revised: 31-03-2017; Accepted: 13-07-2017.

Volume 51, Issue 4 · pp. 562–570 · PUBLISHED 2017 · DOI: 10.5530/ijper.51.4.85

View on IJPER original site ↗

ABSTRACT

Objective: The study was aimed to improve solubility and bioavailability of nateglinide preparing stable solid dispersions with polyoxy ethylene-polyoxy propylene block copolymer (poloxamer 188). Methods: The solid dispersions were prepared by the melting and solvent technique at 1:1, 1:2, 1:3 (w/w) of drug to carrier ratios. The formulations were characterized by fourier transform infrared spectroscopy, diffrential scanning calorimetry, X-ray diffraction, scanning electron microscopy, dissolution behaviour, stability and in vivo performance. Result and Discussion: The results showed an increase in solubility (52.57 fold) and an enhancement in dissolution of solid dispersions compared to pure nateglinide (P<0.05). FTIR showed retainment of individual peaks indicated few characteristics groups in the drug structure. The DSC thermograms and XRD pattern showed the significant change in crystallinity to amorphous of nateglinide. Pharmacokinetic study was performed in rabbits, showed improved bioavailability (1.71 fold, AUC) of nateglinide in solid dispersions (1:3 w/w). Similarly Cmax and Tmax of solid dispersions showed significant difference over the pure drug. Conclusion: The study indicated poloxamer 188 was suitable carrier and melting technique was suitable method for improvement of dissolution and bioavailability of nateglinide.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Swain, R. P., & Subudhi, B. B. (2017). Solid Dispersion of Nateglinide in Polyoxy Ethylene-Polyoxy Propylene Block Copolymer: in vitro and in vivo Evaluation. Indian Journal of Pharmaceutical Education and Research, 51(4), 562–570. https://doi.org/10.5530/ijper.51.4.85