Development and Evaluation of a System for Colonic Delivery of Budesonide

ABSTRACT

In the present study an attempt has been made to address low solubility issue and colonic delivery of Budesonide by developing enteric coated capsule containing Budesonide in a nano emulsifying drug delivery system. Herein, the formulated liquid SNEDDS was transformed to a solid form by spray draying method. Subsequently, it was filled into capsules coated with pH sensitive polymer, Eudragit S- 100 along with band sealing. However, the drug solubility is an important parameter which was determined in different oils, surfactants and co-surfactants. Ternary phase diagrams were constructed to obtain maximum nano-emulsion area. SNEDDS containing Capmule ®MCM L8 as oil, Tween-80 as surfactant and polyethylene glycol 400 as co-surfactant were formulated to get maximum nano-emulsion in the phase diagram. In vitro drug release of the optimized SNEDDS (particle size 116.32 nm) revealed enhanced drug release in colonic pH as compared to pure drug. The developed SNEDDS of budesonide also demonstrated better activity against ulcerative colitis as evidenced by the gradually diminishing morphological damages in the histopathological studies in the TNBS induced ulcerative colitis in rats. Thus, SNEDDS enhanced the solubility of Budesonide while the enteric coating provides its colonic release.

KEYWORDS

• SNEDDS
• Colonic Release
• Budesonide
• Solubility
• In vitro
• In-vivo
• Ulcerative
• Colitis

Showing references and in-text citations exactly as published.

• DOI10.5530/ijper.51.4.84Copy

RELATED ARTICLES

Matched on section and article type within this issue of IJPER.

• Article · VOLUME 51, ISSUE 4Designing of Curriculum Aspects of Pharmacy Undergraduate Course in Respect of Graduate EmployabilityShivaji P.Gawade, Nitin P.Sonaje · pp. 502–509Original ArticleSame type: Article
• Article · VOLUME 51, ISSUE 4Experience of Introduction of the Online Course in Biology for Pharmacy Students in UkraineFiliptsovaOlga FiliptsovaOlga, NabokaOlga NabokaOlga, Gazzavi-RogozinaLyudmila Gazzavi-RogozinaLyudmila, DyominaYevgeniya DyominaYevgeniya, GaliyLarisa GaliyLarisa · pp. 510–516Original ArticleSame type: Article
• Article · VOLUME 51, ISSUE 4Preparation and Evaluation of Matrix Type Transdermal Patches of Domperidone Maleate: in vitro and ex vivo CharacterizationSuddala Shirisha, Gomathi Joshi, Sunit Kumar Sahoo, Yamsani Madhusudan Rao · pp. 517–524Original ArticleSame type: Article
• Article · VOLUME 51, ISSUE 4Formulation and Characterization of Tapentadol Loaded Emulgel for Topical ApplicationNitin Prabhakar Ambhore, Panchaxari Mallapa Dandagi, Anand Panchaxari Gadad, Paresh Mandora · pp. 525–534Original ArticleSame type: Article