Indian Journal of Pharmaceutical Education and Research
Volume 51, Issue 4S
2017 · pp. s661–s666 · 34 articles
- Volume
- 51
- Issue
- 4S
- Published
- 2017
- Pages
- s661–s666
- Articles
- 34
- Sections
- 2
- ISSN
- Online - 0019-5464
- Journal
- IJPER
In this issue
Review Article
- Review
Past and Future of in-vitro and in-vivo Animal Models for Diabetes: A Review
Hemlata Dewangan, Raj Kumar Tiwari, Vikas Sharma, Shiv Shankar Shukla, Trilochan Satapathy, Ravindra Pandey
pp. s522–s530 · DOI: 10.5530/ijper.51.4s.79 · Published 2017
Diabetes mellitus is classified into two major types, Type 1 (Insulin Dependent Diabetes Mellitus) and Type 2 (Non-Insulin Dependent Diabetes Mellitus). In world about 90% of diabetes patients are of Type 2 diabetes. The…
- Review
Non-Animal Models for Research and Toxicity Testing of Drugs
Abhishek Ajmera, Parshuram Shendge
pp. s531–s538 · DOI: 10.5530/ijper.51.4s.80 · Published 2017
All drug discovery methods, right from ‘trial-and-error’ approach to modern rational synthesis of drugs, make use of animals to check for efficacy and toxicity of compounds. This results in millions of animals being sacr…
Original Article
- Article
Development and Evaluation of Fast Dissolving Film for Oro-Buccal Drug Delivery of Chlorpromazine
Md Wasim Hussain, Poonam Kushwaha, Md. Azizur Rahman, Juber Akhtar
pp. s539–s547 · DOI: 10.5530/ijper.51.4s.81 · Published 2017
Objective: Objective was designed to prepare, develop and evaluate fast dissolving films (FDFs) for oro-buccal drug delivery of chlorpromazine. Background: The drug delivery through oro-buccal mucosa is very interesting …
- Article
Process Optimization of Methylphenidate Hydrochloride Extended Release Pellets by QbD
Bala Vishnu Priya Mukkala, Murthy TEGK, Prameela Rani A
pp. s548–s558 · DOI: 10.5530/ijper.51.4s.82 · Published 2017
Objective: The aim of the present research work was to optimize the process of Methylphenidate Hydrochloride (HCl) Extended releasse (ER) pellets based on Quality by Design (QbD) principles. Materials and methods: Wurste…
- Article
Nephroprotective Effect of Low Viscosity Sodium Alginate on Lead Acetate-Induced Nephrotoxicity in Rats
Gagandeep Kaur, Saurabh Sharma
pp. s559–s565 · DOI: 10.5530/ijper.51.4s.83 · Published 2017
Objective: Renal failure in majority of population is considered to be idiopathic. Heavy metals like lead in drinking water are usually the hidden cause of these renal consequences. Thus, this study has been designed to …
- Article
Enhancement of Paclitaxel Oral Bioavailability in Swiss Mice by Four Consecutive Days of Pre-Treatment with Curcumin
Anjna Sharma, Asmita Magotra, Utpal Nandi, Gurdarshan Singh
pp. s566–s570 · DOI: 10.5530/ijper.51.4s.84 · Published 2017
Objective: Poor water solubility, P-glycoprotein (P-gp) efflux property and substrate of CYP3A lead to low oral bioavailability that limit the oral use of paclitaxel, a key anticancer drug. Though several formulation app…
- Article
Microemulsion Based Formulation as Drug Delivery System for Gliclazide
Harsha Kamath, A Sivakumar
pp. s571–s579 · DOI: 10.5530/ijper.51.4s.85 · Published 2017
Purpose: The present study is intended to develop and evaluate oil in water (O/W) microemulsion based formulation for gliclazide as oral drug delivery system for the treatment of diabetes mellitus. Gliclazide, having sul…
- Article
A Research Article on Nanogel as Topical Promising Drug Delivery for Diclofenac sodium
Swati Talele, Preetam Nikam, Braja Ghosh, Chaitali Deore, Ashwini Jaybhave, Anil Jadhav
pp. s580–s587 · DOI: 10.5530/ijper.51.4s.86 · Published 2017
Background: Transdermal delivery of drug is promising but challenging system is available for local as well as systemic effect of drug. The prolonged residence of drug formulation in the skin is important for transdermal…
- Article
Matrix Tablet Containing Quaternary Inclusion Complex of Domperidone for Treatment of Diabetic Gastroparesis
Vishwajeet Sampatrao Ghorpade, Kailas Krishnat Mali, Remeth Jacky Dias, Vijay Daulatrao Havaldar, Ganesh Shankar Raut
pp. s588–s600 · DOI: 10.5530/ijper.51.4s.87 · Published 2017
Objective: The present investigation is aimed at development and optimization of a pH independent controlled release matrix tablet containing mannitol based quaternary inclusion complex (QIC) of domperidone (DOM) for the…
- Article
Comparative in-vivo Evaluation of Anti-Cancer Drugs Loaded Nanospheres
Prakash Katakam, Phalguna Yadagiri
pp. s601–s606 · DOI: 10.5530/ijper.51.4s.88 · Published 2017
Objectives: objective of present research was to formulate and evaluate nanospheres of selected anticancer drugs, viz., Capecitabine (CPN), Tamoxifen (TAM) and Doxorubicin (DXO). The adverse effects associated with antic…
- Article
Evaluation of Antiurolithiatic Potentials of Hydro-Alcoholic Extract of Cucumis sativus L.
Shriram Ramesh Pethakar, Pramod Jayadevappa Hurkadale, Ravindra Durdundayya Hiremath
pp. s607–s614 · DOI: 10.5530/ijper.51.4s.89 · Published 2017
Introduction: Cucumis sativus fruits are claimed for their antiurolithiatic activity in traditional system of medicine. Materials and Methods: Present study was undertaken to evaluate lithotryptic effect using hydro-alco…
- Article
Evaluation of Uterotonic Activity of Hydro-ethanolic Extract of Unripe Fruit of Carica papaya Linn using Wistar Albino Rats
Praveena P, Jethinlalkhosh JP, Victor Arokia Doss
pp. s615–s622 · DOI: 10.5530/ijper.51.4s.90 · Published 2017
Objective: This study was undertaken due to the popular belief in most of the Asian countries that the unripe fruit of Carica papaya L if eaten during early months of pregnancy can lead to miscarriage. The aim of the pre…
- Article
In-vitro Evaluation of Antifungal Activity of Ganoderma lucidum Against the Biofilm Producing Candida species
Naveen kumar C, Jayalakshmi G, Chidambaram R, Srikumar R
pp. s623–s630 · DOI: 10.5530/ijper.51.4s.91 · Published 2017
Background: Bioproducts of mushrooms Ganoderma lucidum have multi beneficial effects for human welfare. Objectives: The aim of the present study was to evaluate antifungal activity of Ganoderma lucidum against the biofil…
- Article
The Optimum Extraction Process for Radix glycyrrhizae and Angelica dahurica (Fisch.) Benth.et Hook with Orthogonal Design
Hong Duan, Ke Feng Zhai, Wen Gen Cao, Gui Zhen Gao, Ling Ling Shan, Liang Zhao
pp. s631–s636 · DOI: 10.5530/ijper.51.4s.92 · Published 2017
Background: To develop the optimal extractive technique of the Radix glycyrrhizae and Angelica dahurica (Fisch.) Benth.et Hook in the Fengshiding dropping pill. Methods: Single factor experiments were carried out on the …
- Article
Determining the Phytochemical Parameters of Pisum sativum (pease) and Effects on the Development of Debaryomyces hansenii
Pınar Erecevit, Sevda Kırbağ
pp. s637–s644 · DOI: 10.5530/ijper.51.4s.93 · Published 2017
Objective: In this work; phytochemical parameters (fatty acid, vitamin, phytosterol, flavonoid and resveratrol contents, and antioxidant activities antimicrobial activities) of Pisum sativum (pease) extracts prepared wit…
- Article
Effect of Metabolic Syndrome on Depression in Mice
Aniruddha Mukherjee, Kalyan K Sen, Sugato Banerjee
pp. s645–s652 · DOI: 10.5530/ijper.51.4s.94 · Published 2017
Metabolic syndrome (MetS) is associated with high blood glucose, insulin resistance, dyslipidemia, central obesity, and hypertension. There is clinical evidence of the coexistence of depression and MetS, however, pathway…
- Article
Impact of Patient Education on Interdialytic Weight Gain and Blood Pressure in Patients Undergoing Hemodialysis
Rini Thainery Padinchare Veetil, Janardhan Kamath, Uday Venkat Mateti
pp. s653–s660 · DOI: 10.5530/ijper.51.4s.95 · Published 2017
Objectives: To assess the impact of patient education on Interdialytic Weight Gain (IDWG) and Blood Pressure (DBP) in patients undergoing hemodialysis (HD). Materials and Methods: A Quasi experimental Pre and Post study …
- Article
Evaluation and Optimization of Effective-dose of Alloxan for Inducing Type-2 Diabetes Mellitus in Long Evans Rat
Shaikh Shahinur Rahman, Nilufar Yasmin, Abu Taher Mohammad Mizanur Rahman, Akteruz zaman, Mohammad Hafizur Rahman, Shakh Mohammad Abdur Rouf
pp. s661–s666 · DOI: 10.5530/ijper.51.4s.96 · Published 2017
Background: The optimal effective and safe dose of alloxan for inducing stable diabetes in rats has been long arguable. Lower doses can result in auto-reversion from diabetogenic state to normal state. On the other hand,…
- Article
How Human Lung Adenocarcinoma Cells React Towards Long-term Metabolic Stress; A Follow Up
Maryam Nakhjavani, Farshad H. Shirazi
pp. s667–s674 · DOI: 10.5530/ijper.51.4s.97 · Published 2017
Introduction: A key challenge in fighting against cancer is cancer recurrence and resistance. Apart from the advances in the field of cancer treatment, the outcome is not still as high as expected. This may be partly due…
- Article
Use of the Herbal OTC Products and Dietary Supplements by Patients Receiving Chemotherapy: Survey-Based Study
Kowalczyk Adam, Bodalska Agnieszka, Boszkiewicz Kamila, Karlowicz Bodalska Katarzyna
pp. s675–s678 · DOI: 10.5530/ijper.51.4s.98 · Published 2017
Context: Among cancer patients receiving chemotherapy, there is a growing trend to use self-medication. Many of them take preparations sold over the counter (OTC) and dietary supplements containing plant raw materials. A…
- Article
Synthesis and Biological Activity of Novel 2,5-Dichloro-3-Acetylthiophene Chalcone Derivatives
Bontha Venkata Subrahmanya Lokesh, Yejella Rajendra Prasad, Afzal Basha Shaik
pp. s679–s690 · DOI: 10.5530/ijper.51.4s.99 · Published 2017
Objective: A series of novel 2, 5-dichloro-3-acetylthiophene chalcone derivatives were synthesized by Claisen-Schmidt condensation and evaluated for them in vitro antifungal, antitubercular activities and cytotoxic activ…
- Article
Role of Ginkgo biloba Extract, Against Isoproterenol Induced Cardiac Toxicity in Rats
Narendra Singh Badore, Prabhat Kumar Das, Sujit Pillai, Akshita Thakur
pp. s691–s699 · DOI: 10.5530/ijper.51.4s.100 · Published 2017
Objective: Ginkgo biloba is a potent antioxidant dietary source for human health. Oxidative stress through generation of free radicals damages the myocardium in different experimental condition. The present research was …
- Article
Green Expedient Synthesis of Pyrimidine Derivatives via Chalcones and Evaluation of their Anthelmintic Activity
Biswa Mohan Sahoo, Mullangi Rajeswari, Panda Jnyanaranjan, Sahoo Binayani
pp. s700–s706 · DOI: 10.5530/ijper.51.4s.101 · Published 2017
Objective: In the present study, we focused on the environment-friendly processes used for the preparation of pyrimidine derivatives with pharmacological properties. In this regard, microwave heating is used as the alter…
- Article
Synthesis and in-vitro Antioxidant Activity of Novel Schiff Bases and Azetidines Derived from Phenyl Urea Derivatives
Veera Raghavulu Nagavolu, Shankarananth Velusamy, Sridhar Chechugari, Prasanna Raju Yalavarthi, Manasa Karani
pp. s707–s711 · DOI: 10.5530/ijper.51.4s.102 · Published 2017
Objective: The Schiff bases and azetidines are important intermediates used in synthesis of several therapeutics and medicinally contributing molecules. This research was focused on synthesis of Schiff bases and azetidin…
- Article
Antiobesity Potential of Fresh Cow Urine and its Distillate - A Biomedicine for Tomorrow
Sanjay Sharma, Ketan Hatware, Ashwini Deshpande, Payal Dande, Sravani Karri
pp. s712–s721 · DOI: 10.5530/ijper.51.4s.103 · Published 2017
Background: The cow urine has been used traditionally for the management of many diseases and also used as bio-enhancer to improve their therapeutic effect. Objective: To prepare and evaluate the anti-obesity potential o…
- Article
Comparative Study of Various Non-Nucleoside Reverse Transcriptase Inhibitors on Different Reverse Transcriptase Enzyme
Shital Manoj Patil, Kalyani Dhirendra Asgaonkar, Trupti Sameer Chitre, Aditi Kinikar, Chaitali Kharat, Vaibhavi Bhoirekar, Madhura Athavale, Mitali Katkar
pp. s722–s728 · DOI: Comparative Study of Various Non-Nucleoside Reverse Transcriptase Inhibitors on Different Reverse Transcriptase Enzyme · Published 2017
Context: Acquired immunodeficiency Syndrome (AIDS) is caused by Human immunodeficiency virus type 1 (HIV-1). 4-Thiazolidone nulecus is the target pharmacophore which have diverse biological activities including anti HIV …
- Article
A Rapid and Sensitive Bio Analytical RP-HPLC Method for Detection of Docetaxel: Development and Validation
Prachi Balaram Kharkar, Swapnil Sunil Talkar, Vandana Bharat Patravale
pp. s729–s734 · DOI: 10.5530/ijper.51.4s.105 · Published 2017
Objective: A rapid and selective high-performance liquid chromatographic (HPLC) method has been developed and validated for Docetaxel anhydrous (DTX) using Ketoconanzole (KCZ) as an internal standard in biological fluids…
- Article
Phytochemical Screening and Evaluation of Cytotoxic Effect and Antioxidant Activity of Fractions Isolated from Stenochlaena palustri (Burm.f.) Bedd. Leaves
Sangeetha Arullappan, Sakunie Sawai, Lew Ann Chee, Meerashri Mahandan, Ragaventhan Shanmugavelan
pp. s735–s740 · DOI: 10.5530/ijper.51.4s.106 · Published 2017
Introduction: Stenochlaena palustris (Burm.f.) Bedd. is an edible fern from Blechnaceae family, native to India through Southeast Asia to Polynesia and Australia. The study was conducted to evaluate the cytotoxic effect …
- Article
Protective Effects of Biochanin A against Methotrexate-Induced Acute Liver Injury in Rats
Erdem Kamil Ozer, Mustafa Tugrul Goktas, Aysun Toker, Ceyhan Ugurluoglu, Hulagu Bariskaner
pp. s741–s746 · DOI: 10.5530/ijper.51.4s.107 · Published 2017
Background: Methotrexate (MTX) is one of the most commonly used chemotherapeutic agents in the treatment of cancer patients, however its therapeutic use is limited due to dose dependent hepatotoxicity caused by oxidative…
- Article
Investigation of in vitro Antioxidant and Anti-inflammatory Activities of Selected Siddha Polyherbal Formulations
Perumal Rajalakshmi, Vellingiri Vadivel, Pemaiah Brindha
pp. s747–s753 · DOI: 10.5530/ijper.51.4s.108 · Published 2017
Objective: This study deals with the antioxidant and anti-inflammatory activities of selected Siddha polyherbal formulations such as Amukkara choornam, Thirikadugu choornam, Eladi choornam and Thiripala choornam. Amukkar…
- Article
The Development and Validation of Stability Indicating Analytical Method for Determination of Nortriptyline in Nortriptyline HCl Tablets by Liquid Chromatography
Tukaram B Sawant, Dhananjay V. Mane
pp. s761–s768 · DOI: 10.5530/ijper.51.4s.110 · Published 2017
Purpose: To develop and validate a rapid, rugged, precise and an accurate stability indicating analytical method for determination of Nortriptyline HCl in Nortriptyline tablets. The separation of impurities and Nortripty…
- Article
Stability Indicating HPLC Method Using Core Shell Stationary Phase for the Determination of Related Substances in Levocetirizine Dihydrochloride Oral Solution
Venkata Krishna Akula, Barij Nayan Sinha, Han Jeong seok
pp. s769–s775 · DOI: 10.5530/ijper.51.4s.111 · Published 2017
Rationale:Levocetirizine (LCZ) is a new generation antihistamine drug used for the allergic symptoms resulting from various diseases. The present research work focuses on the development of a simple and precise HPLC meth…
- Article
Development and Validation of UV-Derivative Spectroscopic and RP-HPLC Methods for the Determination of Amlodipine Besylate and Valsartan in Tablet Dosage form and Comparison of the Developed Methods by Student’s T-Test
Usharani N, Divya K, Ashrtiha VVS
pp. s776–s782 · DOI: 10.5530/ijper.51.4s.112 · Published 2017
Introduction: Hypertension is directly responsible for 51% of all stroke deaths and 45% of all coronary heart diseases worldwide. Amlodipine besylate is a calcium channel blocker used as an anti-hypertensive agent. Valsa…
- Article
Development and Validation of Inductively Coupled Plasma Atomic Emission Spectroscopy [ICP-AES] Analytical Method for Estimation of Cisplatin in Biological Samples
Shruti Akshay Wagle, Darshana Jain, Sudha Rathod, Rajani Athawale, Amrita Bajaj
pp. s783–s789 · DOI: 10.5530/ijper.51.4s.113 · Published 2017
Objective: Cisplatin, a popular anti-neoplastic agent is employed as a first line treatment for variety of cancers. Majority of the analytical methods reported for Cisplatin are either complex or not suitable for routine…