jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Green Expedient Synthesis of Pyrimidine Derivatives via Chalcones and Evaluation of their Anthelmintic Activity

Biswa Mohan Sahoo1★, Mullangi Rajeswari1, Panda Jnyanaranjan2, Sahoo Binayani3★ Corresponding author

  1. 1Department of Pharmaceutical Chemistry, Vikas College of Pharmacy, Vissannapeta, Krishna District, Andhra Pradesh, INDIA.
  2. 2Department of Medicinal Chemistry, Roland Institute of Pharmaceutical Sciences, Khodasingi, Berhampur, Odisha, INDIA.
  3. 3Department of Chemistry, M.V.R Degree College, Nuzvid, Krishna University, Andhra Pradesh, INDIA.

CORRESPONDENCE

Biswa Mohan Sahoo

Department of Pharmaceutical Chemistry, Vikas College of Pharmacy, Vissannapeta, Krishna District, Andhra Pradesh, INDIA.

drbiswamohansahoo@gmail.com

Received: 20-07-2017; Revised: 17-09-2017; Accepted: 23-11-2017.

Volume 51, Issue 4S · pp. s700–s706 · PUBLISHED 2017 · DOI: 10.5530/ijper.51.4s.101

View on IJPER original site ↗

ABSTRACT

Objective: In the present study, we focused on the environment-friendly processes used for the preparation of pyrimidine derivatives with pharmacological properties. In this regard, microwave heating is used as the alternative energy sources to synthesize a series of pyrimidine derivatives by the condensation of chalcones with urea under basic conditions. Chalcones were synthesized by Claisen-Schimidt condensation of acetophenone with various substituted benzaldehyde in the presence of ethanolic potassium hydroxide solution. Methods: The IR, 1H-NMR, mass spectra and CHN analyses confirmed the structure of the prepared compounds. Shorter reaction time, environment friendly procedure and excellent yields are the advantages of microwave synthesis. The newly synthesized pyrimidine derivatives were screened for their anthelmintic activity and found to have moderate to considerable activity as compared to the standard drug. Results: Some of the synthesized compounds exhibited significant anthelmintic activity. Compound 4e with electron withdrawing groups was found to be highly potent among the series. This attempt will lead to an increased number of new and sustainable methods for the synthesis of biologically-active pyrimdine derivatives.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Sahoo, B. M., Rajeswari, M., Jnyanaranjan, P., & Binayani, S. (2017). Green Expedient Synthesis of Pyrimidine Derivatives via Chalcones and Evaluation of their Anthelmintic Activity. Indian Journal of Pharmaceutical Education and Research, 51(4S), s700–s706. https://doi.org/10.5530/ijper.51.4s.101