Non-Animal Models for Research and Toxicity Testing of Drugs
Abhishek Ajmera1, Parshuram Shendge1★★ Corresponding author
- 1Department of Pharmacology, School of Pharmacy and Technology Management SVKM’s NMIMS, Shirpur Campus, Dhule, Maharashtra, INDIA.
CORRESPONDENCE
Parshuram Shendge
Department of Pharmacology, School of Pharmacy and Technology Management SVKM’s NMIMS, Shirpur Campus, Dhule, Maharashtra, INDIA.
Received: 14-04-2017; Revised: 08-05-2017; Accepted: 25-09-2017.
Volume 51, Issue 4S · pp. s531–s538 · PUBLISHED 2017 · DOI: 10.5530/ijper.51.4s.80
ABSTRACT
All drug discovery methods, right from ‘trial-and-error’ approach to modern rational synthesis of drugs, make use of animals to check for efficacy and toxicity of compounds. This results in millions of animals being sacrificed every year. Following a global debate on “cruelty of animals”, various acts were made and enforced in order to protect animal rights. As a work, around to these animal protection acts, drug discovery scientists started finding alternative approaches to animal studies for research. This review attempts to compile some of the more important non-animal models which are being used for testing safety and efficacy of drugs in preclinical stages.
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Ajmera, A., & Shendge, P. (2017). Non-Animal Models for Research and Toxicity Testing of Drugs. Indian Journal of Pharmaceutical Education and Research, 51(4S), s531–s538. https://doi.org/10.5530/ijper.51.4s.80