Matrix Tablet Containing Quaternary Inclusion Complex of Domperidone for Treatment of Diabetic Gastroparesis

ABSTRACT

Objective: The present investigation is aimed at development and optimization of a pH independent controlled release matrix tablet containing mannitol based quaternary inclusion complex (QIC) of domperidone (DOM) for the treatment of diabetic gastroparesis. Methods: The tablets were prepared by direct compression and central composite design was used to optimize the amount of sodium alginate (SA) and hydroxypropylmethylcellulose (HPMC) to obtain a final formulation with desired release characteristics. The drug release from the optimized formulation was compared with the tablets containing pure DOM, binary and ternary inclusion complexes. Results and Discussion: The formulations showed a zero order release profile. The design models suggested greater influence of SA on the drug release. The optimized formulation showed minimum burst effect and released 88.65±3.19% DOM at the end of 12 h. The comparative study revealed that the optimized formulation exhibited nearly complete release of DOM. Conclusion: It was concluded that the optimized formulation containing QIC may reduce the dose frequency and improve the bioavailability of DOM.

KEYWORDS

• Quaternary inclusion complex
• pH independent controlled release
• Domperidone
• Central composite design
• Diabetic gastroparesis

Showing references and in-text citations exactly as published.

• DOI10.5530/ijper.51.4s.87Copy

RELATED ARTICLES

Matched on section and article type within this issue of IJPER.

• Article · VOLUME 51, ISSUE 4SDevelopment and Evaluation of Fast Dissolving Film for Oro-Buccal Drug Delivery of ChlorpromazineMd Wasim Hussain, Poonam Kushwaha, Md. Azizur Rahman, Juber Akhtar · pp. s539–s547Original ArticleSame type: Article
• Article · VOLUME 51, ISSUE 4SProcess Optimization of Methylphenidate Hydrochloride Extended Release Pellets by QbDBala Vishnu Priya Mukkala, Murthy TEGK, Prameela Rani A · pp. s548–s558Original ArticleSame type: Article
• Article · VOLUME 51, ISSUE 4SNephroprotective Effect of Low Viscosity Sodium Alginate on Lead Acetate-Induced Nephrotoxicity in RatsGagandeep Kaur, Saurabh Sharma · pp. s559–s565Original ArticleSame type: Article
• Article · VOLUME 51, ISSUE 4SEnhancement of Paclitaxel Oral Bioavailability in Swiss Mice by Four Consecutive Days of Pre-Treatment with CurcuminAnjna Sharma, Asmita Magotra, Utpal Nandi, Gurdarshan Singh · pp. s566–s570Original ArticleSame type: Article