Evaluation of Antiurolithiatic Potentials of Hydro-Alcoholic Extract of Cucumis sativus L.

ABSTRACT

Introduction: Cucumis sativus fruits are claimed for their antiurolithiatic activity in traditional system of medicine. Materials and Methods: Present study was undertaken to evaluate lithotryptic effect using hydro-alcoholic extract of Cucumis sativus (HCS). Ethylene glycol (0.75% v/v) was used to induce calculi in Wistar albino rats. Assessed various parameters like, Biochemical, Histopathological and routine urine analysis. Results: Treatment with preventive and curative doses of HCS was found to exert dose dependent antiurolithiatic action. Increased urine volume in HCS treated groups as compared to diseased group was indicative of diuretic property. Elevated calcium, phosphate and oxalate levels in diseased group animal were found to be decreased in animals treated with HCS. Increased levels of serum creatinine, BUN and uric acid were considerably brought down towards normal values in proportion to HCS doses administered. Histopathology of kidney reveals severe renal damage due toperformed crystals. Animals treated with HCS showed remarkable recovery, suggestive of prevention of nucleation and aggregation of stone forming components. Conclusion: It can be concluded that, results are supportive to claims made. The exact mechanism of antiurolithiatic effect may further needs to be studied.

KEYWORDS

• Cucumis sativus
• Antiurolithiatic
• Ethylene glycol (0.75 % v/v)
• Diuretic
• Cystone
• Kidney stone

Showing references and in-text citations exactly as published.

• DOI10.5530/ijper.51.4s.89Copy

RELATED ARTICLES

Matched on section and article type within this issue of IJPER.

• Article · VOLUME 51, ISSUE 4SDevelopment and Evaluation of Fast Dissolving Film for Oro-Buccal Drug Delivery of ChlorpromazineMd Wasim Hussain, Poonam Kushwaha, Md. Azizur Rahman, Juber Akhtar · pp. s539–s547Original ArticleSame type: Article
• Article · VOLUME 51, ISSUE 4SProcess Optimization of Methylphenidate Hydrochloride Extended Release Pellets by QbDBala Vishnu Priya Mukkala, Murthy TEGK, Prameela Rani A · pp. s548–s558Original ArticleSame type: Article
• Article · VOLUME 51, ISSUE 4SNephroprotective Effect of Low Viscosity Sodium Alginate on Lead Acetate-Induced Nephrotoxicity in RatsGagandeep Kaur, Saurabh Sharma · pp. s559–s565Original ArticleSame type: Article
• Article · VOLUME 51, ISSUE 4SEnhancement of Paclitaxel Oral Bioavailability in Swiss Mice by Four Consecutive Days of Pre-Treatment with CurcuminAnjna Sharma, Asmita Magotra, Utpal Nandi, Gurdarshan Singh · pp. s566–s570Original ArticleSame type: Article