jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Comparative Study of Various Non-Nucleoside Reverse Transcriptase Inhibitors on Different Reverse Transcriptase Enzyme

Shital Manoj Patil1★, Kalyani Dhirendra Asgaonkar1, Trupti Sameer Chitre1, Aditi Kinikar1, Chaitali Kharat1, Vaibhavi Bhoirekar1, Madhura Athavale1, Mitali Katkar1★ Corresponding author

  1. 1Department of Pharmaceutical chemistry, All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy, Pune, INDIA.

CORRESPONDENCE

Shital Manoj Patil

Department of Pharmaceutical chemistry, All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy, Pune, INDIA.

shital_patil@aissmscop.com

Received: 23-08-2017; Revised: 14-09-2017; Accepted: 09-10-2017.

Volume 51, Issue 4S · pp. s722–s728 · PUBLISHED 2017 · DOI: Comparative Study of Various Non-Nucleoside Reverse Transcriptase Inhibitors on Different Reverse Transcriptase Enzyme

View on IJPER original site ↗

ABSTRACT

Context: Acquired immunodeficiency Syndrome (AIDS) is caused by Human immunodeficiency virus type 1 (HIV-1). 4-Thiazolidone nulecus is the target pharmacophore which have diverse biological activities including anti HIV activity. Aim: To study binding behavior of thiazolidinone derivatives on four different crystal structures of HIV- 1RT. Material and Method: Binding pattern of some thiazolidinone derivatives was gauged by molecular docking studies on four different receptors bearing PDB code 1ZD1, 1RT2, 1KLM, 1FKP of HIV–RT enzyme using V. Life MDS software. Result and Discussion: The studies revealed hydrogen bonds, hydrophobic interaction and pi-pi interactions playing significant role in binding of the molecules to the enzyme. Conclusion: Interactions, binding energy and dock score of molecule 6 was comparable with the standard drugs.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    • DOIComparative Study of Various Non-Nucleoside Reverse Transcriptase Inhibitors on Different Reverse Transcriptase Enzyme

    SELECT FORMAT

    Patil, S. M., Asgaonkar, K. D., Chitre, T. S., Kinikar, A., Kharat, C., Bhoirekar, V., Athavale, M., & Katkar, M. (2017). Comparative Study of Various Non-Nucleoside Reverse Transcriptase Inhibitors on Different Reverse Transcriptase Enzyme. Indian Journal of Pharmaceutical Education and Research, 51(4S), s722–s728. https://doi.org/Comparative Study of Various Non-Nucleoside Reverse Transcriptase Inhibitors on Different Reverse Transcriptase Enzyme