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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Development and Validation of Inductively Coupled Plasma Atomic Emission Spectroscopy [ICP-AES] Analytical Method for Estimation of Cisplatin in Biological Samples

Shruti Akshay Wagle1★, Darshana Jain2, Sudha Rathod1, Rajani Athawale3, Amrita Bajaj4★ Corresponding author

  1. 1Oriental College of Pharmacy, Sector 2, Plot No 3, 4, 5, Sanpada (W), Navi Mumbai, Maharashtra, INDIA.
  2. 2C.U.Shah College of Pharmacy, S.N.D.T Women’s University, Santacruz (W), Mumbai, Maharashtra, INDIA.
  3. 3Principal K.M Kundnani College of Pharmacy, Plot No. 23, Jote Joy Building, Rambhau Salgaonkar Road, Cuffe Parade, Mumbai, Maharashtra, INDIA.
  4. 4SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, V.M Road, Vile Parle (W), Mumbai, Maharashtra, INDIA.

CORRESPONDENCE

Shruti Akshay Wagle

Oriental College of Pharmacy, Sector 2, Plot No 3, 4, 5, Sanpada (W), Navi Mumbai, Maharashtra, INDIA.

wagleshruti85@gmail.com

Received: 30-06-2017; Revised: 06-07-2017; Accepted: 14-10-2017.

Volume 51, Issue 4S · pp. s783–s789 · PUBLISHED 2017 · DOI: 10.5530/ijper.51.4s.113

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ABSTRACT

Objective: Cisplatin, a popular anti-neoplastic agent is employed as a first line treatment for variety of cancers. Majority of the analytical methods reported for Cisplatin are either complex or not suitable for routine analysis of the drug. Hence, there is a need for development of suitable analytical technique like ICP-AES for quantitation of Cisplatin in complex matrices and biological samples. Methods: Cisplatin was analyzed in the present study based on its single step conversion to platinum metal with aqua regia. Results: The developed method was validated and was found to be linear in the range of 0.375 to 15 μg/ml with a regression coefficient of 0.992. The percent recoveries of Cisplatin from plasma and tissue samples ranged from 95 to 99%. Discussion: A simple, low cost, sensitive, one step ICP-AES technique was developed and validated for bioanalytical estimation of Cisplatin.

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    Wagle, S. A., Jain, D., Rathod, S., Athawale, R., & Bajaj, A. (2017). Development and Validation of Inductively Coupled Plasma Atomic Emission Spectroscopy [ICP-AES] Analytical Method for Estimation of Cisplatin in Biological Samples. Indian Journal of Pharmaceutical Education and Research, 51(4S), s783–s789. https://doi.org/10.5530/ijper.51.4s.113