Volume 52, Issue 4

Naziya Rafi, Sandeep DS, Anoop Narayanan V

pp. 544–549 · DOI: 10.5530/ijper.52.4.63 · 2018

A generic drug is more efficient, safe and low-cost alternative of the innovator or branded drug in the market. They are similar to the branded drugs in strength, quality, purity and their safety and efficacy have been p…

Shery Jacob, Mohamed Aly Morsy, Anroop Nair

pp. 550–557 · DOI: 10.5530/ijper.52.4.64 · 2018

Insulin preparations are the mainstay in the management of type 1 along with various type 2 diabetes. Available insulin preparations are either short-acting or long-acting or mixture to mimic the physiological insulin se…

Christine Liang Hoay Tan, Vincent Beng Yong Gan, Fahad Saleem, Mohamed Azmi Ahmad Hassali

pp. 558–574 · DOI: 10.5530/ijper.52.4.65 · 2018

The Malaysian Government through the National Health Policy aims to improve health outcomes through public pharmaceutical healthcare services. Pharmacy Value Added Services (PVAS) was introduced as a matter of public pha…

Kaveh Eslami, Leila Kouti, Maryam Aghakouchakzadeh, Mina Khezrian, Mandana Izadpanah

pp. 575–580 · DOI: 10.5530/ijper.52.4.66 · 2018

Introduction: Personal computers or laptops and smartphones has been used to change the lecture based traditional class to an interactive workshop to educate the knowledge and skills necessary for using drug information …

Naglakshmi Sethuraman, Shanmuganathan S, Sandhya K, Anbarasan B

pp. 581–586 · DOI: 10.5530/ijper.52.4.67 · 2018

Objective: Aceclofenac is non steroidal anti inflammatory drug (NSAID) and is considered to be first line drug in treatment of rheumatoid arthritis, osteo arthritis and ankylosing spondylitis. Aceclofenac undergoes first…

Bharani S Sogai, Vikram B Narayansetty, Ramana Murthy V Kolapalli

pp. 587–593 · DOI: 10.5530/ijper.52.4.68 · 2018

Purpose: To compare pharmacokinetics and bioavailability of saquinavir (SQV) and ritonavir (RTV) and their optimized cyclodextrin complexes of anti-retro viral drugs after oral administration into rats. Methods: Rats wer…

Joyani Das, Papiya Mitra Mazumder

pp. 594–601 · DOI: 10.5530/ijper.52.4.69 · 2018

Background: Quercetin, a bioflavonoid, with wide natural occurrence has been found to possess numerous pharmacological benefits. Aim: The present work deals with exploring efficacy of Quercetin against diabetic macrovasc…

Maryam Nakhjavani, Farshad H. Shirazi

pp. 602–609 · DOI: 10.5530/ijper.52.4.70 · 2018

Introduction: Tumour is a heterogeneous tissue consisting of cells with different levels of metabolic activity. Often the outer layer cells of a tumour have more optimal conditions to grow/proliferate compared to the inn…

Sabita Upreti, Rajendra SV, Kuntal Das, Arjan Aryal

pp. 610–617 · DOI: 10.5530/ijper.52.4.71 · 2018

Objective:To evaluate the effect of MESA on NDEA induced hepatocellular carcinoma on Sprague Dawley rats. Methodology: Semecarpus anacardium commonly known as ‘marking nut tree’ is a rich antioxidant and in Ayurveda it h…

Mohammad Khushtar, Aijaz Ahmad, Md. Azizur Rahman

pp. 618–625 · DOI: 10.5530/ijper.52.4.72 · 2018

Objective: Gastroprotective effect of hydro-alcoholic extract of Polygonum bistorta Linn root (HEPB) was investigated in indomethacin-induced gastric ulcer in Sprague Dawley rats. Background: Polygonum bistorta has been …

Nil Kılıç, Mehmet Kürşat Derici, İlker Büyük, Semra Soydam Aydın, Sümer Aras, Demet CansaranDuman

pp. 626–634 · DOI: 10.5530/ijper.52.4.73 · 2018

Lichens and their secondary metabolite are still among the many unexamined natural sources in the drug industry. This study was designed to evaluate the cytotoxic effects of vulpinic acid lichen secondary metabolite and …

T N V Ganesh Kumar, S Vidyadhara, Niteen Ashok Narkhede, N Yamini Sai Silpa, M Rajya Lakshmi

pp. 635–643 · DOI: 10.5530/ijper.52.4.74 · 2018

Saroglitazar is a newly approved oral hypoglycemic drug by FDA. Although the drug entered the market, there are no reports on its degradation products till date. To identify the degradation products of saroglitazar durin…

Shashi Kant Singh, Saurabh Kumar Sinha, Mrunal Krishnarao Shirsat

pp. 644–654 · DOI: 10.5530/ijper.52.4.75 · 2018

Introduction: Alzheimer’s disease (AD) is a slowly progressive devasting neurodegenerative disorder of central nervous system manifested by deterioration of memory, cognitive functions, behaviour change and impairment in…

Rohit Singh, Swastika Ganguly

pp. 655–665 · DOI: 10.5530/ijper.52.4.76 · 2018

Objective:In the present study, a series of nineteen compound of 1-phenyl-3-(5-phenyl1H-imidazol-1-yl) thiourea derivatives (5a-9b) were designed, synthesized, characterized by physicochemical and spectral data (IR, 1H N…

Catna Nagaraj Hemalath, Vijey Aanandhi Muthukumar

pp. 666–675 · DOI: 10.5530/ijper.52.4.77 · 2018

Introduction: Telomerase is an enzyme which binds to telomeres and increases its length which leads to extension of lifespan of cells. These enzymes are expressed at detectable levels in cancer cells which makes an attra…

Mithbavkar Jay Rajaram, Tapkir Amit Suryakant, Gaur Ashwani, Chaudhary Pravin

pp. 676–683 · DOI: 10.5530/ijper.52.4.78 · 2018

Introduction: Accurate quantitation of biomarkers is always challenging, it becomes really tedious when biomarker has poor retention on chromatographic column and possess a chemical structure resistant for derivatisation…

Nishant Kumar Soni, Chandan Kumar Verma

pp. 691–698 · DOI: 10.5530/ijper.52.4.80 · 2018

Bacterium Mycobacterium tuberculosis is the causative agent for the disease tuberculosis (TB) and is responsible for more than ten million different infections with an additional accountability for about two million deat…

Afzal Hussain, Chandan Kumar Verma

pp. 699–706 · DOI: 10.5530/ijper.52.4.81 · 2018

Background: COT (Tpl2/MAP3K8) is a Serine/ Threonine protein kinase which plays a crucial role in the production of TNF-alpha through the phosphorylation of MEK, ERK pathway and the production of other pro-inflammatory c…

Nivya James, Raunaq Surana, Isha Thigale, B. Preethi, V. Shanthi, K. Ramanathan

pp. 707–717 · DOI: 10.5530/ijper.52.4.82 · 2018

Introduction: Recent years has witnessed major paradigm shifts in the treatment of NSCLC with the emergence of biomarkers and targeted therapies. Most importantly, ALK is a validated biomarker and its inhibition using ta…