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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Development and Evaluation of Nevirapine Extended Release Tablets using QbD Approach

Vasantakumar Pai Karkala1, Harsha Jinadatharaya1, Devagowda Vishakante Gowda2★, Praveen Sivadasu Department o1,2★ Corresponding author

  1. 1Department of Industrial Chemistry, Kuvempu University Shankaraghatta, B. R. Project, Shimoga-577451, Karnataka, INDIA.
  2. 2Department of Pharmaceutics, JSS Academy for Higher Education and Research, JSS College of Pharmacy, SS Nagara, Mysore.

CORRESPONDENCE

Devagowda Vishakante Gowda

Department of Pharmaceutics, JSS Academy for Higher Education and Research, JSS College of Pharmacy, SS Nagara, Mysore.

dvgowdajssuni@gmail.com

Received: 15-02-2018; Revised: 17-05-2018; Accepted: 14-08-2018.

Volume 52, Issue 4S · pp. s220–s228 · PUBLISHED 2018 · DOI: 10.5530/ijper.52.4s.101

View on IJPER original site ↗

ABSTRACT

Objective:To develop and evaluate Nevirapine (NVP) Extended release tablets for reducing the dosing frequency using Methylcellulose USP Methocel A15-LV and Hypromellose USP Methocel K4M Premium CR used as rate retarding polymers and Magnesium stearate as lubricant. Methods: Tablets were prepared by using roller compaction technique by employing Quality by Design (QbD) and Design of Experimentation (DoE) to study the effect of various process related parameters like Bulk density, Tapped density, Compressibility index, mesh size and in-vitro release data at 20th hour. Results: Obtained results had suggested that concentration of polymer had shown a potential effect over various process parameters and in-vitro drug release studies suggested that formulated tablets had shown a sustained release up to 24h when compared with marketed formulations. Conclusion: From the obtained results it can be concluded that formulation of Nevirapine ER Tablets employing QbD lead to a single dose per day in the management of HIV/AIDS.

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    Karkala, V. P., Jinadatharaya, H., Gowda, D. V., & o, P. S. D. (2018). Development and Evaluation of Nevirapine Extended Release Tablets using QbD Approach. Indian Journal of Pharmaceutical Education and Research, 52(4S), s220–s228. https://doi.org/10.5530/ijper.52.4s.101