Development of a Validated Stability Indicating Liquid Chromatographic Method for the Determination of Pterostilbene
Mukthinuthalapati Mathrusri Annapurna1★, Bukkapatnam Venkatesh1, Gunnam Ravi Teja1★ Corresponding author
- 1Department of Pharmaceutical Analysis and Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam-530045, Andhra Pradesh, INDIA.
CORRESPONDENCE
Mukthinuthalapati Mathrusri Annapurna
Department of Pharmaceutical Analysis and Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam-530045, Andhra Pradesh, INDIA.
Received: 28-11-2017; Revised: 24-01-2018; Accepted: 17-05-2018.
Volume 52, Issue 4S · pp. s63–s70 · PUBLISHED 2018 · DOI: 10.5530/ijper.52.4s.77
ABSTRACT
Introduction: Pterostilbene, a stilbenoid possess diversified pharmacological activities. In the present study, a stability-indicating liquid chromatographic method was proposed for the determination of Pterostilbene in pharmaceutically available formulations. Materials and Methods: The chromatographic separation was achieved on Phenomenex C8 type column as stationary phase. UV detection was carried out at 219 nm. Pterostilbene was subjected to various stress conditions such as acidic, alkaline, oxidative, thermal and photolytic degradations. Results:The drug was found to be sensitive towards acidic and alkaline stress conditions. The proposed method was validated as per the ICH guidelines and successfully applied to the available marketed formulations. Conclusion: The proposed method is selective, specific, robust and can be applied for the assay of pharmaceutical dosage forms.
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Annapurna, M. M., Venkatesh, B., & Teja, G. R. (2018). Development of a Validated Stability Indicating Liquid Chromatographic Method for the Determination of Pterostilbene. Indian Journal of Pharmaceutical Education and Research, 52(4S), s63–s70. https://doi.org/10.5530/ijper.52.4s.77