jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Association between Selective Serotonin Reuptake Inhibitors Use and Colorectal Cancer in a CaseControl Study

Shih-Wei Lai1,2, Cheng-Li Lin1,3, Kuan-Fu Liao4,5★★ Corresponding author

  1. 1Department of Family Medicine, College of Medicine, China Medical University, Taichung, TAIWAN.
  2. 2Department of Family Medicine, China Medical University Hospital, Taichung, TAIWAN.
  3. 3Department of Management Office for Health Data, China Medical University Hospital, Taichung, TAIWAN.
  4. 4Department of Internal Medicine, College of Medicine, Tzu Chi University, Hualien, TAIWAN.
  5. 5Department of Hepatogastroenterology, Department of Internal Medicine, Taichung Tzu Chi Hospital, Taichung, TAIWAN.

CORRESPONDENCE

Kuan-Fu Liao

Department of Internal Medicine, College of Medicine, Tzu Chi University, Hualien, TAIWAN.

kuanfuliaog@gmail.com

Received: 09-07-2018; Revised: 14-08-2018; Accepted: 18-01-2019.

Volume 53, Issue 2 · pp. 325–329 · PUBLISHED 2019 · DOI: 10.5530/ijper.53.2.41

View on IJPER original site ↗

ABSTRACT

Objectives: This study’s aim was to investigate whether selective serotonin reuptake inhibitors use was associated with the risk of colorectal cancer. Methods: From the claims data of Taiwan National Health Insurance Program, a retrospective case-control study was conducted to examine 4739 aged 20-84 cases with newly diagnosed colorectal cancer in 2000-2013 and 4739 sex-matched and age-matched controls without colorectal cancer. The prescription history of selective serotonin reuptake inhibitors and other comorbidities were compared between the cases and the matched controls. Results: After adjusting for the potential confounders, the multivariable logistic regression model showed that the odds of selective serotonin reuptake inhibitors use among cases with colorectal cancer were lower than the odds of selective serotonin reuptake inhibitors use among matched controls (adjusted OR 0.77; 95% CI 0.66-0.89). Conclusion: The odds of selective serotonin reuptake inhibitors use among cases with colorectal cancer are lower than among matched controls. This finding indicates that selective serotonin reuptake inhibitors use might be a protective factor against colorectal cancer.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Lai, S., Lin, C., & Liao, K. (2019). Association between Selective Serotonin Reuptake Inhibitors Use and Colorectal Cancer in a CaseControl Study. Indian Journal of Pharmaceutical Education and Research, 53(2), 325–329. https://doi.org/10.5530/ijper.53.2.41