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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Clinical Effects of Pantoprazole and Octreotide in Upper Gastrointestinal Hemorrhage

Yong Wang1, Fei Deng2★★ Corresponding author

  1. 1Department of Gastroenterology, Hanchuan People’s Hospital, Xiaogan, Hubei, CHINA.
  2. 2Department of Respiratory Medicine, Hanchuan People’s Hospital, Xiaogan, Hubei, CHINA.

CORRESPONDENCE

Fei Deng

Department of Respiratory Medicine, Hanchuan People’s Hospital, Xiaogan, Hubei, CHINA.

fei_deng666@126.com

Received: 22-06-2018; Revised: 14-08-2018; Accepted: 29-12-2018.

Volume 53, Issue 2 · pp. 330–333 · PUBLISHED 2019 · DOI: 10.5530/ijper.53.2.42

View on IJPER original site ↗

ABSTRACT

Objective:This study aimed to discuss the clinical effects of pantoprazole and octreotide in upper gastrointestinal hemorrhage. Methods: A total of 114 patients with upper gastrointestinal hemorrhage admitted in our hospital from April 2016 to June 2017 were chosen and divided into control and experimental groups by lottery method. The control group (n=57) was treated with pantoprazole and the experimental group (n=57) was treated with pantoprazole+ octreotide. The therapeutic effect, occurrence rate of untoward effects, hemostatic effects at 24 and 72 h, blood-transfusion volume, hemostatic time and rehemorrhage rate at 48 h of the two groups were compared. Results: Compared with the control group, the experimental group exhibited significantly higher total therapeutic and hemostatic effects at 24 h, as well as lower occurrence rate of untoward effects and hemostatic effects at 24 h. Statistically significant differences were observed between the control and experimental groups (P<0.05). The experimental group had greater blood-transfusion volume, shorter hemostatic time and higher rehemorrhage rate at 48 h (P<0.05). Conclusion: The pantoprazole+ octreotide therapy exerted outstanding clinical effects on upper gastrointestinal hemorrhage. This combined therapy can decrease the occurrence rate of untoward effects and bloodtransfusion volume, reduce hemostatic time and prevent recurrent bleeding, thereby being worthy of clinical use and promotion.

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    Wang, Y., & Deng, F. (2019). Clinical Effects of Pantoprazole and Octreotide in Upper Gastrointestinal Hemorrhage. Indian Journal of Pharmaceutical Education and Research, 53(2), 330–333. https://doi.org/10.5530/ijper.53.2.42