Formulation, Development and Evaluation of Etoricoxib Nanosize Microemulsion Based Gel for Topical Drug Delivery

ABSTRACT

Introduction: Etoricoxib is a poorly water-soluble oral NSAID and is associated with a number of complications such as bleeding, ulcers and dyspepsia but these can be overcome by delivering the drug topically. Objectives: Microemulgel for the topical delivery of etoricoxib was formulated to increase its solubility and thus improve the skin permeability. Methods: The solubility of etoricoxib was studied in various oils, surfactants and cosurfactants. Pseudo-ternary phase diagrams were constructed by varying the surfactant to cosurfactant (Smix) ratio. Microemulsions with different compositions were formulated and optimized. Selected o/w microemulsions contained 1% etoricoxib and were evaluated for pH, rheology, drug content, particle size and in vitro drug release. Optimized microemulsion was incorporated in 1% Carbopol® 934 and was evaluated for rheological properties, spreadability, in vitro permeation, skin irritation and stability. Results: Capryol™ 90, Tween 80 and Transcutol® P exhibited the highest solubility. Maximum microemulsion region was observed when the Smix ratio was 3:1. The average particle size of the optimized microemulsion was 37.61 nm, zeta potential was -2.88 mV and permeability of the drug from the microemulsion was 66.8% after 8 h. The prepared gel showed 57.8% drug release after 8 hr. Skin irritation studies indicated that the optimized formulation was safe for topical application. Stability studies indicated that the formulation remained unaffected at accelerated storage conditions. Conclusion: Results indicated that the micro-emulgel has potential for sustained action of drug release and may act as a promising tool to enhancepercutaneous delivery of etoricoxib.

KEYWORDS

• Etoricoxib
• Microemulsion
• Topical gel
• in vitro release
• Particle size
• Skin
• irritation

Showing references and in-text citations exactly as published.

• DOI10.5530/ijper.53.4s.152Copy

RELATED ARTICLES

Matched on section and article type within this issue of IJPER.

• Article · VOLUME 53, ISSUE 4SDesign, Development and Evaluation of Self Nanoemulsifying Drug Delivery System of Garlic Oil using Capryol PGMCPriyanka Sangar, Bandgar Sandip, Shelake Sardar, Patil Pravin, Bhagwat Durgacharan, Patil Shitalkumar · pp. s539–s547Original ArticleSame type: Article
• Article · VOLUME 53, ISSUE 4SFormulation and Development of Famotidine Solid Dispersion Tablets for their Solubility EnhancementShirsath Nitin Rajendra, Jagtap Vaibhavkumar, Goswami Ajaygiri Kamalgiri · pp. s548–s553Original ArticleSame type: Article
• Article · VOLUME 53, ISSUE 4SSolvent-free Hot Melt Extrusion Technique in Improving Mesalamine Release for Better Management of Inflammatory Bowel DiseaseRudra Narayan Sahoo, Ananya De, Vishal Kataria, Subrata Mallick · pp. s554–s562Original ArticleSame type: Article
• Article · VOLUME 53, ISSUE 4SDesign and Preparation of Zaltoprofen-Nicotinamide Pharmaceutical Cocrystals via Liquid Assisted Grinding MethodPrabhakar Panzade, Giridhar Shendarkar · pp. s563–s570Original ArticleSame type: Article