Volume 53, Issue 4S

2019 · pp. s481–s486 · 31 articles

Volume: 53
Issue: 4S
Published: 2019
Pages: s481–s486
Articles: 31
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Review Article Original Article

In this issue

Review Article

Review
New Drugs and Clinical Trials Rules, 2019: Towards Fast-track Accessibility of New Drugs to the Indian Population
Akhilesh Dubey, Bhasini Kotian, Ravi Gundadka Shriram
pp. s451–s459 · DOI: 10.5530/ijper.53.4s.138 · Published 2019
Background: To fulfil the objective of fast-tracking the accessibility of new drugs and promoting clinical research in India, the Union Ministry of Health and Family Welfare, India has notified the “New Drugs and Clinica…
Review
Improved Method for Differentiation of Synthetic and Natural Endogenous Anabolic Steroids using Gas Chromatography Isotope Ratio Mass Spectrometry (GC/C/IRMS) followed by Two-Fold High Performance Liquid Chromatography (HPLC) Cleanup Method: A Perspective
Abhinav Shrivastava, Shila Jain, Puran Lal Sahu, Sangeeta Shukla, Kapendra Sahu
pp. s460–s465 · DOI: 10.5530/ijper.53.4s.139 · Published 2019
Background: Androgenic Anabolic Steroids (AAS) are also synthetic derivatives of testosterone, modified to improve its anabolic actions. The misuse of AAS is of particular concern in sports and society. Gas chromatograph…
Review
A Review on Complications Confronted with Skin Penetration and Assessment of Topical Formulations in Dermal Drug Development
Kalikrishna Praveen Gadde, Angel Treasa Alex, Alex Joesph
pp. s466–s474 · DOI: 10.5530/ijper.53.4s.140 · Published 2019
A topical drug-delivery system is the most accepted drug delivery system. One of the pre-requisites for a topical formulation is its ability to penetrate the skin membrane to elicit the intended action. Many in vitro ski…
Review
Recent Advancements in Spectrophotometric pKa Determinations: A Review
Job Herman Berkhout, Aswatha Ram HN
pp. s475–s480 · DOI: 10.5530/ijper.53.4s.141 · Published 2019
The pKa value is a key feature in Absorption, Distribution, Metabolism and Excretion (ADME) of drugs, thus knowing this value is critical in drug development. In this review, pKa values determined in the past decade, usi…
Review
Therapeutic Proteins through Phage Display- A Brilliant Technique for its Simplicity
Sreerama Krupanidhi
pp. s481–s486 · DOI: 10.5530/ijper.53.4s.142 · Published 2019
Background: Phage Display Technology is an advanced version of rDNA and hybridoma technologies with simplicity in its procedure and production of desired therapeutics and biocontrol products. In this context, the filamen…
Review
Difficulties Facing the Patients and Extra Burden for Healthcare Providers by Non-adherence to the Medications - A Comprehensive Review
Yahaya Hassan, Ahmed Alaa Al-Temimi, Rizwan Ramli, Mohd Firdaus M. Saad, Noorizan A. Aziz
pp. s487–s499 · DOI: 10.5530/ijper.53.4s.143 · Published 2019
Background: Compliance is commonly and always being confused with concordance, which is a process by which a patient and health care provider make discussion and decisions together about treatment and their outcomes. Gen…
Review
Propolis Research in Russia
Victoria Vladimirovna Fedotova, Dmitry Alexeevich Konovalov
pp. s500–s509 · DOI: 10.5530/ijper.53.4s.144 · Published 2019
This review presents data on the current propolis research in Russia. The chemical composition, color, aroma and appearance of propolis are influenced by natural and climatic factors, the collection region and the origin…
Review
Genotoxicity of Monosodium Glutamate: A Review on its Causes, Consequences and Prevention
Rabbani Syed Imam
pp. s510–s517 · DOI: 10.5530/ijper.53.4s.145 · Published 2019
Monosodium Glutamate (MSG) is a common food additive used in processed foods to enhance the taste. The data available on Google scholar, NCBI, PUBMED, EMBASE, Wang fang databases, meta-analysis and Web of Science were re…
Review
Genotype-8: A Modern Family Member of Hepatitis C Virus
Sai Krishna Gudi, Manik Chhabra, Muhammed Rashid
pp. s518–s521 · DOI: 10.5530/ijper.53.4s.146 · Published 2019
Hepatitis C Virus (HCV) is a highly diverse and pervasive disease around the globe, with a prevalence ranging from 1.5 to 2.3%. With wide genetic variability, it is classified into seven Genotypes (GT) with 67 subtypes. …
Review
Insight into Concept and Progress on Pharmaceutical Co-Crystals: An Overview
Venkata Deepthi Vemuri, Srinivas Lankalapalli
pp. s522–s538 · DOI: 10.5530/ijper.53.4s.147 · Published 2019
Pharmaceutical co-crystals have conferred significant recognition in recent past as a new solid form by virtue their capability to modulate physicochemical properties of Active Pharmaceutical Ingredient (API). Neverthele…

Original Article

Article
Design, Development and Evaluation of Self Nanoemulsifying Drug Delivery System of Garlic Oil using Capryol PGMC
Priyanka Sangar, Bandgar Sandip, Shelake Sardar, Patil Pravin, Bhagwat Durgacharan, Patil Shitalkumar
pp. s539–s547 · DOI: 10.5530/ijper.53.4s.148 · Published 2019
Introduction: At present days there was considerable attention has been taken to develop lipid based pharmaceutical preparation which improves solubility as well as permeability leads to improve oral bioavailability of p…
Article
Formulation and Development of Famotidine Solid Dispersion Tablets for their Solubility Enhancement
Shirsath Nitin Rajendra, Jagtap Vaibhavkumar, Goswami Ajaygiri Kamalgiri
pp. s548–s553 · DOI: 10.5530/ijper.53.4s.149 · Published 2019
Background: Famotidine is BCS class II drug having a low aqueous solubility and low oral bioavailability. It needs to develop into its novel form for solubility and dissolution rate enhancement. Materials and Methods: Th…
Article
Solvent-free Hot Melt Extrusion Technique in Improving Mesalamine Release for Better Management of Inflammatory Bowel Disease
Rudra Narayan Sahoo, Ananya De, Vishal Kataria, Subrata Mallick
pp. s554–s562 · DOI: 10.5530/ijper.53.4s.150 · Published 2019
Background: Poor oral bioavailability of mesalamine (Mes) is due to extensive metabolism in the intestinal epithelial cells in addition to the liver. Purpose: Improved mesalamine release by Hot-Melt Extrusion (HME) techn…
Article
Design and Preparation of Zaltoprofen-Nicotinamide Pharmaceutical Cocrystals via Liquid Assisted Grinding Method
Prabhakar Panzade, Giridhar Shendarkar
pp. s563–s570 · DOI: 10.5530/ijper.53.4s.151 · Published 2019
Introduction: Pharmaceutical cocrystal is an endowed approach to augment solubility and dissolution of drugs with limited aqueous solubility. Zaltoprofen is a nonsteroidal anti-inflammatory drug with prevailing solubilit…
Article
Formulation, Development and Evaluation of Etoricoxib Nanosize Microemulsion Based Gel for Topical Drug Delivery
Vania Rachael Fonseca, Prashant Jivaji Bhide, Madhusudan Purushottam Joshi
pp. s571–s579 · DOI: 10.5530/ijper.53.4s.152 · Published 2019
Introduction: Etoricoxib is a poorly water-soluble oral NSAID and is associated with a number of complications such as bleeding, ulcers and dyspepsia but these can be overcome by delivering the drug topically. Objectives…
Article
Sustained Release Bioadhesive Suppository Formulation for Systemic Delivery of Ornidazole: In-silico Docking Study
Rasmita Dash, Rudra Narayan Sahoo, Souvik Nandi, Rakesh Swain, Subrata Mallick
pp. s580–s586 · DOI: 10.5530/ijper.53.4s.153 · Published 2019
Background and Objectives:Ornidazole is widely used as an antiprotozoal and antiamoebic drug and its onset of action is within 2 h. The major extent of the drug is metabolized in the liver and excreted in the urine and f…
Article
Development and Bioavailability Assessment of Ramipril Nanoparticle Formulation
Annie Pereira, Anand Panchakshari Gadad, Archana Sidagouda Patil, Panchakshari Mallappa Dandagi
pp. s587–s595 · DOI: 10.5530/ijper.53.4s.154 · Published 2019
Ramipril, potent anti-hypertensive agent has been used in the treatment of hypertensive disorders. It has low bioavailability of 28-35% and short biological half-life (i.e. 2-4 hr). Thus this study attempts to evaluate c…
Article
Formulation and Evaluation of Tamoxifen Citrate Loaded Transdermal Reservoir Gel Drug Delivery Systems
Nagaraja SreeHarsha, Jagadeesh G Hiremath, Bimlesh Kumar Rawre, Niranjan Puttaswamy, Bandar E Al-Dhubiab, Katharigatta N. Venugopala, Sabah H Akrawi, Girish Meravanige, Mahesh Attimarad, Anroop B Nair
pp. s596–s606 · DOI: 10.5530/ijper.53.4s.155 · Published 2019
Background: Successful treatment of cancer is yet remained as a challenging concern in public health. Transdermal delivery of hormonal therapy offers several advantages over the oral route associated with potential side …
Article
Screening and Identification of Plant Metabolites against Snake Venom Enzymes using in vitro to in silico Approach
Pushpendra Singh, Mohammad Yasir, Rahul Shrivastava
pp. s607–s618 · DOI: 10.5530/ijper.53.4s.156 · Published 2019
Aim/Background: Snakebites are generally a neglected tropical disease that have harmful impact on thousands of people globally. Although antiserum therapy is the only management available for snakebites, several side eff…
Article
Development of Non-invasive Electroencephalography Technique in Animal Model
Vasudeva Murthy Sindgi, Mounika Basani, Pragna Choudary, Kashinath Molugu, Ramesh Malothu
pp. s619–s623 · DOI: 10.5530/ijper.53.4s.157 · Published 2019
Aim: This paper describes about the new non-invasive method to measure brain waves from the scalp of the rats. The method allows to record good quality Electroencephalogram (EEG) from freely moving rats in the cage. Meth…
Article
One Step Towards: The Synthesis of Optimized Coumarin Derivatives as an Anti-HIV Agent
Vikas Kumar, Indra Prashad Pandey, Jainendra Jain, Ram Babu Tripathi
pp. s624–s629 · DOI: 10.5530/ijper.53.4s.158 · Published 2019
The development for the sustainable approach was a key ingredient for the research, especially in the field of drug development against HIV. Several attempts have been made in the positive direction for the treatment of …
Article
Stress Degradation Studies of Riociguat, Development of Validated Stability Indicating Method, Identification, Isolation and Characterization of Degradation Products by LC-HR-MS/MS and NMR Studies
Charu P Pandya, Sadhana J Rajput
pp. s630–s641 · DOI: 10.5530/ijper.53.4s.159 · Published 2019
Aim: The present study reports the degradation behavior of new antihypertensive drug Riociguat under various stress conditions as per International Conference on Harmonization guidelines ICH, Q2(R1). Materials and Method…
Article
Development and Validation of Genotoxic Impurity in Esomeprazole Magnesium Trihydrate Active Pharmaceutical Ingredient by LC-MS/MS
Suresh Reddy Yelampalli, Venkata Shanmukha Kumar Jagarlapudi, Useni Reddy Mallu
pp. s642–s649 · DOI: 10.5530/ijper.53.4s.160 · Published 2019
Objectives: A rapid, sensitive and selective analytical method has been developed and validated by liquid chromatography tandem Mass spectrometry (LC-MS/MS) for the quantification of traces of Cumene Hydroperoxide in Eso…
Article
Potential Effect of Steroidal Alkaloids from Sarcococca saligna against Leishmania tropica
Naeem Ullah Jan, Bashir Ahmad, Muhammad Kifayatullah, Haroon Rahim, Fazli Amin
pp. s650–s654 · DOI: 10.5530/ijper.53.4s.161 · Published 2019
Background and Objectives:Sarcococca species have a rich source of steroidal alkaloids that possess different biological and pharmacological activities. Hence, present research was design to isolate the steroidal alkaloi…
Article
Novel Chroman Analogs as Promising Heterocyclic Compounds: Their Synthesis and Antiepileptic Activity
Pinki Rawat, Saurabh Manaswita Verma, Piyush Kumar
pp. s655–s665 · DOI: 10.5530/ijper.53.4s.162 · Published 2019
Aim: New series of novel chroman analogs was designed and synthesized using appropriate synthetic route. Materials and Methods: Structures of synthesized chroman hydrazides fused with different anhydrides were supported …
Article
Complimentary Effects of Curcumin for Enhancing Efficacy of Acetylsalicylic Acid against Prostate Cancer
Tapas Kumar Mohapatra, Debasish Mohapatra, Bharat Bhusan Subudhi
pp. s666–s677 · DOI: 10.5530/ijper.53.4s.163 · Published 2019
Background: Prostate cancer is the 6th leading cause of cancer death worldwide. Androgen Deprivation Therapy (ADT) in prostate cancer enhances the risk of Rheumatoid Arthritis (RA). Acetylsalicylic Acid (ASA) can be pote…
Article
Cassia auriculata L.: An Ethno Medical Approach in Exploring Anti-solar Efficacy
Krantisinha Hanumant Randive, Ravindra Durdundayya Hiremath, Amolkumar Ashok Kempwade, Anagha Ashok Patil
pp. s678–s683 · DOI: 10.5530/ijper.53.4s.164 · Published 2019
Objectives: The present study deals with an in-vitro screening for the anti-solar potential of aqueous and ethanolic extracts of Cassia auriculata using the UV method. Methods: Aqueous and ethanolic extracts were prepare…
Article
Analgesic and Anti-allodynic Effects of Two Flavonoids in Partial Sciatic Nerve Ligation in Rat Model
A.C. Rana, Bhawna Gulliya, Swati Rana
pp. s684–s690 · DOI: 10.5530/ijper.53.4s.165 · Published 2019
Background: Flavonoids, also called as bioflavonoids, are secondary metabolites of plants. Flavonoids, curcumin and hesperidin, possess various pharmacological activities such as analgesic, anti-ulcer, anti-parkinson, an…
Article
Stability-Indicating RP-HPLC Method for the Quantification of Paliperidone in Bulk and Solid Dosage Form to Establish Validation and Stability Indicating Parameters
Sadashivaiah Rudragangaiah, Rohith Ganapathi Bhatta, Satheesha Babu Birur Kotappa
pp. s691–s698 · DOI: 10.5530/ijper.53.4s.166 · Published 2019
Objectives: In the present research work, stability indicating reverse phase high performance liquid chromatography method was developed and validated for the quantification of paliperidone in bulk and solid dosage form.…
Article
Analytical Quality by Design Assisted HPLC Method for Quantification of Canagliflozin/ Metformin and Stability Studies
Sunitha Gurrala, Shivaraj Shivaraj, CVS Subrahmanyam, Panikumar Durga Anumolu, Gowthami Saraf
pp. s699–s709 · DOI: 10.5530/ijper.53.4s.167 · Published 2019
Aim: Current work entails the analytical quality by design (AQbD) based robust HPLC method for real-time analysis of canagliflozin and metformin. Different pKa values of two drugs made their chromatographic separation cr…
Article
Pharmacognostical and Proximal Analysis of Two different Extracts (Methanol and Aqueous) of Indian Endangered Coscinium fenestratum Stem
Kuntal Das
pp. s710–s720 · DOI: 10.5530/ijper.53.4s.168 · Published 2019
Background: Coscinium fenestratum (CF) (Family: Menispermaceae), an endangered and highly commercial medicinal plant of traditional system of medicine. Stem is commercially important which have multiple medicinal used an…