Volume 54, Issue 1

Original Article

1. Article

   Emerging Non-Pharmacological Therapies for Post-stroke Depression and its Future Aspects: A Review

   Keerthana Chandrasekar, Nakka Gautam Sai, Princy Sabu John, Sruthi Ninan, Raja Durai, Sivasankaran Ponnusankar

   pp. 1–7 · DOI: 10.5530/ijper.54.1.1 · Published 2020

   Post-Stroke Depression (PSD) is a psychiatric disorder associated with stroke which has an adverse effect on the cognitive function and survival. It usually develops in 40% of the stroke survivors within 3 months. We per…

2. Article

   Treatment of Osteoporosis: Current Scenario from a Research Perspective

   Pooja Umesh Pherwani, Sadhana Sathaye

   pp. 8–16 · DOI: 10.5530/ijper.54.1.2 · Published 2020

   Osteoporosis is a condition of compromised bone quality and bone density increasing the chances of fracture. In osteoporotic bone, there is a mismatch between bone formation and resorption. The high probability in both w…

3. Article

   Calculating and Evaluating of the Achievements of Pharmaceutical Separation Engineering Course for Pharmaceutical Engineering Major Based on Engineering Education Certification

   Hua Li, Xiaohua Shi

   pp. 17–21 · DOI: 10.5530/ijper.54.1.3 · Published 2020

   Aim: This study aims to evaluate the efficiency of the achievement degree for engineering education certification, example as pharmaceutical separation engineering course. The calculating method of achievement degree abo…

4. Article

   Preconception of Pharmacy Students for the Inclusion of Entrepreneurship Curriculum in the PharmD Program

   Ahmed Abdelrahman Albarraq, Hafiz Antar Makeen, David Banji

   pp. 22–30 · DOI: 10.5530/ijper.54.1.4 · Published 2020

   Objectives: Pharmacy program offers many entrepreneurial opportunities in hospital, community and industrial sectors. Entrepreneurship is recognized, implemented and encouraged in many Universities around the world as a …

5. Article

   Formulation and Evaluation of Solid Lipid Nanoparticle Containing Silver Sulfadiazine for Second and Third Degree Burn Wounds and its Suitable Analytical Method Development and Validation

   Vinayak Shivamurthi Mastiholimath, Coutinho Tracy Whitney Valerie, Vinodkumar Shrishailappa Mannur, Panchaxari Mallappa Dandagi, Anand Panchaxari Gadad, Pukar Khanal

   pp. 31–45 · DOI: 10.5530/ijper.54.1.5 · Published 2020

   Aim: The main aim of this research work was to formulate, characterize and evaluate solid lipid nanoparticles containing Silver sulfadiazine. Materials and Methods: Solid lipid nanoparticles were prepared by hot homogeni…

6. Article

   Spray Dried Amorphous Form of Simvastatin: Preparation and Evaluation of the Buccal Tablet

   Nagaraja SreeHarsha, Jagadeesh Gurupadayya Hiremath, Suhas Sarudkar, Mahesh Attimarad, Bandar Al-Dhubiab, Anroop Balachandran Nair, Katharigatta Narayanaswamy Venugopala, Afzal Haq Asif

   pp. 46–54 · DOI: 10.5530/ijper.54.1.6 · Published 2020

   Background: The success of a drug primarily depends on its bioavailability. By enhancing the solubility and dissolution properties of drugs that are scarcely water soluble, significantly improves their bioavailability. M…

7. Article

   Formulation and Evaluation of Cefixime Nanosuspension for the Enhancement of Oral Bioavailability by Solvent-Antisolvent Method and its Suitable Method Development

   Vinayak Shivamurthi Mastiholimath, Bhagat Ankita Rajendra, Vinodkumar Shirshalappa Mannur, Panchaxari Mallappa Dandagi, Anand Panchaxari Gadad, Pukar Khanal

   pp. 55–67 · DOI: 10.5530/ijper.54.1.7 · Published 2020

   Aim: The objective of the present study was to develop and evaluate cefixime nanosuspension to enhance its oral bioavailability. Materials and Methods: The method used was solvent/ antisolvent method in which methanol an…

8. Article

   Quantitative Estimation of Tabletability of Aceclofenac after Incorporation of Titanium Dioxide using Area under the Curve

   Souvik Nandi, Satyaki Aparajit Mishra, Rudra Narayan Sahoo, Rakesh Swain, Subrata Mallick

   pp. 68–72 · DOI: 10.5530/ijper.54.1.8 · Published 2020

   Background: Tablet manufacturing with direct compression is one of the leading industrial technique that consumes less time, labour and economic also. But the choice of excipients are critical in this case which will all…

9. Article

   Direct Brain Targeted Nanostructured Lipid Carriers for Sustained Release of Schizophrenic Drug: Formulation, Characterization and Pharmacokinetic Studies

   Praveen Sivadasu, Devagowda Vishakante Gowda, Nithin Kundachira Subramani, Bhavya Malgur Vishweshwaraiah, Sachhidananda Shivanna, Siddaramaiah Hatna

   pp. 73–84 · DOI: 10.5530/ijper.54.1.9 · Published 2020

   Background: Systemic drug delivery in schizophrenia is a major challenge, owing to the Blood-brain Barrier (BBB) and P-glycoprotein related effects. Consequently, herein an attempt is made to systemically deliver the mos…

10. Article

    Antiproliferative Effect of Crude Venom from Conus virgo on Human Lung Cancer Cell Line and Toxicity Assessment on Adult Zebra Fish (Danio rerio)

    Dhana Sekaran Ganesan, Mohamed Asik Raj Mohamed, Pema Lhanzin, Kathirvel Neelan, Lakshmanan Vadakkuvaselvi, Sellamuthu Subramani, Arulvasu Chinnasamy

    pp. 85–94 · DOI: 10.5530/ijper.54.1.10 · Published 2020

    Background: For the past two decades, few conotoxins entered in clinical trial and some are available for pain relieving as well as for treatment of neurological disorders. Aim: The present investigation was made to eluc…

11. Article

    Protective Effect of Capsaicin against Doxorubicin Induced Cardiotoxicity in Experimental Rats

    Sanjiv Karale, Yamuna PV, Jagadish V Kamath

    pp. 95–100 · DOI: 10.5530/ijper.54.1.11 · Published 2020

    Aim: The aim of the present study was to evaluate the Cardioprotective effect of Capsaicin (CAP) against Doxorubicin (DOX) induced cardiotoxicity in experimental rats. Methods: The 24 wistar rats were randomly divided in…

12. Article

    Immunomodulatory Potential of Leptadenia arborea in Immune-Challenged Rats

    Iman Hassan Abdoon, Bushra Parveen, Bashier Osman, Mona S Mohamed, Wadah JA Osman, Sayeed Ahmad

    pp. 101–107 · DOI: 10.5530/ijper.54.1.12 · Published 2020

    Background: Plant-based remedies play a crucial role as powerful health aid worldwide. In recent years, the usage of complementary and alternative medicines has grown rapidly. The objective of the present study was to ev…

13. Article

    Effect of Vanillic Acid on Nerve Conduction Velocity in Chronic Constriction Injury Model of Neuropathy

    Shubhangi Pawar, Shubham Khairnar, Vinod Patil, Rajendra Bhambar

    pp. 108–113 · DOI: 10.5530/ijper.54.1.13 · Published 2020

    Background: Neuropathic Pain (NP) is less or symptomatically managed by presently available therapeutics. Therefore developing more effective drugs with minimum adverse effects is essential. Vanillic acid is phenolic sec…

14. Article

    Design of ALK Inhibitors for Non-Small Cell Lung Cancer – A Fragment Based Approach

    Anika Jain, Nivya James, Veerapapillai Shanthi, Karuppasamy Ramanathan

    pp. 114–124 · DOI: 10.5530/ijper.54.1.14 · Published 2020

    Background: The increasing cases of non-small cell lung cancer pose a relentless threat to human health. Therefore, using fragment-based drug discovery as the modus operandi, the present study aimed to design small molec…

15. Article

    Bilateral Ovariectomy Decreases the Levels of Cyclic Nucleotides and Nuclear Phosphorylated Estrogen Receptor-Alpha in Memory-Sensitive Rat Brain Regions

    Ahsas Goyal, Debapriya Garabadu

    pp. 125–134 · DOI: 10.5530/ijper.54.1.15 · Published 2020

    Aim/Background: The level of phosphorylated Estrogen Receptor alpha (ERα) in the nucleus was investigated in different memory-sensitive brain regions of estrogendeficient female rats. Further, the levels of cyclic nucleo…

16. Article

    Preliminary Assessment of Acute and 28-Day Repeated Dose Oral Toxicity of a Newly Developed Herbal Mixture on Experimental Animal

    Soumendra Darbar, Srimoyee Saha, Kausikisankar Pramanik, Atiskumar Chattopadhyay

    pp. 135–142 · DOI: 10.5530/ijper.54.1.16 · Published 2020

    Objectives: Toxicity is an expression of being poisonous, indicating the state of adverse effects led by the interaction between toxicants and cells. The present study was designed to evaluate the acute oral toxicity stu…

17. Article

    Ameliorative Potential of Allium cepa Lam. Leaves on Diabetes Induced and Chronic Constriction Injury Induced Neuropathic Pain in Experimental Rats

    Dureshahwar Khan, Mubashir Mohammed, Aman Upaganlawar, Chandrashekhar D. Upasani, Hemant D. Une

    pp. 143–149 · DOI: 10.5530/ijper.54.1.17 · Published 2020

    Background: Neuropathy can be induced in rats by peripheral injuries, depending on compression of complete or a section of sciatic nerve and chemically by Streptozotocin (STZ). Materials and Methods: In the present study…

18. Article

    Method Development and Validation for Detection of Procaterol in Human Urine using Gas Chromatography-Tandem Mass Spectrometry

    Shila Jain, Puran Lal Sahu, Srashti Raj, Abhinav Shrivastava, Ashok Kumar Maurya, Rajiv Kumar Tonk, Kapendra Sahu

    pp. 150–154 · DOI: 10.5530/ijper.54.1.18 · Published 2020

    Background: A simple, sensitive and accurate method for the determination of procaterol in human urine was developed and validated using Gas Chromatography coupled to tandem mass spectrometry (GC-MS/MS) as per the requir…

19. Article

    Development and Validation of HPTLC Method along with Forced Degradation Study for the Simultaneous Estimation of Azelastine Hydrochloride and Fluticasone Propionate in Nasal Spray Formulation using Design of Experiment Approach

    Kalpana Govindbhai Patel, Seena Ghanshyam Kumar Patel, Purvi Apurva Shah, Devang Bhagvandas Tandel, Tejal Ricky Gandhi

    pp. 155–165 · DOI: 10.5530/ijper.54.1.19 · Published 2020

    Objectives: The present research study focuses on the development of the highperformance thin layer chromatographic method using design of experiment approach for the simultaneous estimation of Azelastine hydrochloride a…

20. Article

    Eco-friendly Derivative UV Spectrophotometric Methods for Simultaneous Determination of Diclofenac Sodium and Moxifloxacin in Laboratory Mixed Ophthalmic Preparation

    Muhammad Shahzad Chohan, Rafea Elamin Elgack Elgorashe, Abdulmalek Ahmed Balgoname, Mahesh Attimarad, Nagaraja SreeHarsha, Katharigatta Narayanaswamy Venugopala, Anroop Balachandran Nair, Shinu Pottathil

    pp. 166–174 · DOI: 10.5530/ijper.54.1.20 · Published 2020

    Background: Diclofenac Sodium (DCL) and Moxifloxacin HCl (MOX) were simultaneously used after cataract surgery to reduce the post-operative inflammation and to control infection respectively. Objectives: Three simple, ac…

21. Article

    Modelling Customers’ Buying Behaviour of Jan Aushadhi (Generic Medicines)

    Maruthi Haluvarthy Nagarajappa, Hosur Srinivasan Srivatsa

    pp. 175–186 · DOI: 10.5530/ijper.54.1.21 · Published 2020

    Background: Jan Aushadhi, a scheme to make affordable generic drugs available to large sections of population was launched by the Government of India across the country in the year 2008. This exploratory research was con…

22. Article

    Development and Validation of Reverse-Phase High-Performance Liquid Chromatographic Method for Determination of Resveratrol in Human and Rat Plasma for Preclinical and Clinical Studies

    Satveer Jagwani, Sunil Jalalpure, Dinesh Dhamecha, Gan Siew Hua, Kiran Jadhav

    pp. 187–193 · DOI: 10.5530/ijper.54.1.22 · Published 2020

    Aim: The aim of the study was to develop and validate a simple and precise reverse-phase High Performance Liquid Chromatography (RP-HPLC) method for quantitative analysis of trans-resveratrol in human and rat plasma. Met…

23. Article

    Community Pharmacists’ Attitudes and Professional Practice in Relation to the Patient Safety Incidents

    Valentina Marinkovic, Tatjana Stojkovic, Milica Zekovic, Ljiljana Tasic, Dusanka Krajnovic

    pp. 194–205 · DOI: 10.5530/ijper.54.1.23 · Published 2020

    Background: Medicines dispensing is an error-prone activity, therefore potentially jeopardizing patient safety. This study aimed to assess the community pharmacists’ attitudes towards the causes of dispensing errors and …

24. Article

    Formulation and Evaluation of Antibacterial Topical Gel of Doxycycline Hyclate, Neem Oil and Tea Tree Oil

    Vishwanath Abasaheb Borse, Avinash Balasaheb Gangude, Anil Bhavrao Deore

    pp. 206–212 · DOI: 10.5530/ijper.54.1.24 · Published 2020

    Purpose:To formulate novel topical antibacterial gel containing Doxycycline Hyclate, Tea tree oil and Neem oil to evaluate their antibacterial activity. Methods: Formulation excipients were selected using Drug-excipients…

25. Article

    Natural and Synthetic Polymers Assisted Development of Lurasidone Hydrochloride Intranasal Mucoadhesive Microspheres

    Shoaib Khan, Purushottam Shridhar Gangane, Debarshi Kar Mahapatra, Nilesh Manoharrao Mahajan

    pp. 213–222 · DOI: 10.5530/ijper.54.1.25 · Published 2020

    Objectives: To avoid the first-pass metabolism of the drug (lurasidone HCl) and further improving its contact time with the nasal mucosa, intranasal mucoadhesive microspheres were developed by using natural (chitosan) an…