Volume 54, Issue 2S

2020 · pp. s368–s373 · 40 articles

Volume: 54
Issue: 2S
Published: 2020
Pages: s368–s373
Articles: 40
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Review Article Original Article

In this issue

Review Article

Review
Supercritical Fluid Technology and its Pharmaceutical Applications: A Revisit with Two Decades of Progress
Liew Kai Bin, Ashok Kumar Janakiraman, Fashli Syafiq Abd Razak, A.B.M. Helal Uddin, Md Zaidul Islam Sarker, Long Chiau Ming, Bey Hing Goh
pp. s1–s11 · DOI: 10.5530/ijper.54.2s.56 · Published 2020
Over the past two decades, supercritical fluid technology has emerged as one of the most important technologies applied in many fields such as cosmetic, food and pharmaceutical. Supercritical fluid extraction process off…
Review
Modified Pectins for Colon-Specific Drug Delivery
Aneesh Muvva, Indhu Annie Chacko, Vivek Ghate, Shaila Angela Lewis
pp. s12–s18 · DOI: 10.5530/ijper.54.2s.57 · Published 2020
Treatment of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome and colonic cancer by targeting drug to the colon is a viable approach. Due to gastric degradation of drugs, proteins and …
Review
Comparability Pathway for the Approval of Similar Biologics with Respect to Reference Biologics in Europe and Brazil
Lakshmi Prasanthi Nori, Prasuna Ravi
pp. s19–s31 · DOI: 10.5530/ijper.54.2s.58 · Published 2020
The regulatory environment for biologics is continuously evolving, because they are ensuring the targeted therapies for many dreadful diseases. But the high cost of biologics has made the European Union to go for the bio…
Review
Lipid Nanocarriers: Promising Approach for Oral Drug Delivery System
Vinod Kumar Yadav, Devegowda Vishakante Gowda, Balamuralidhara Veeranna
pp. s32–s42 · DOI: 10.5530/ijper.54.2s.59 · Published 2020
Background: A suitable drug delivery system has been work on the strategy to enable safe and effective therapeutic efficacy. Drug discovery program, it has huge number of drug molecules are lipophilic as poor aqueous sol…
Review
Caspase Activators: Phytochemicals with Apoptotic Properties Targeting Cancer, A Health Care Strategy to Combat this Disease
Asma Saqib, Sharath Pattar, Chandrakant S Karigar, Shailasree Sekhar
pp. s43–s55 · DOI: 10.5530/ijper.54.2s.60 · Published 2020
Context: Caspases, a family of cysteine-aspartic proteases have a pivotal role in apoptotic pathways. Their down-regulation is reported to induce inappropriate cell survival and enhanced carcinogenic potential. Screening…
Review
A Paradoxically Significant Medicinal Plant Carapichea ipecacuanha: A Review
Sinjini Mondal, Saurav Moktan
pp. s56–s66 · DOI: 10.5530/ijper.54.2s.61 · Published 2020
Background: Carapichea ipecacuanha (Brot.) L. Andersson is the botanical source of Ipecac drug and contains major alkaloids emetine, cephaline that are pharmaceutically used against bronchitis associated with cough in ch…
Review
Apple Cider Vinegar (ACV) and their Pharmacological Approach towards Alzheimer’s Disease (AD): A Review
Smriti Tripathi, Papiya Mitra Mazumder
pp. s67–s74 · DOI: 10.5530/ijper.54.2s.62 · Published 2020
Alzheimer's disease (AD) is a neurological degenerative condition described by a progressive decline in memory and associated with dementia. This disease arises usually after 65 years in individuals. Oxidative stress is …

Original Article

Article
Upskilling of Pharmacy Faculty in an Accredited Institution through Modular Training in Strategic Education Practices with Formative and Summative Assessments
Bahubali Gundappa Nagavi, M. Chandra Sekar
pp. s75–s78 · DOI: 10.5530/ijper.54.2s.63 · Published 2020
Aim: To study the impact of Modular Faculty training on the attitude of faculty, motivation towards self–directed learning and team learning. Train the faculty on new teaching and learning tools and assessment. Assess th…
Article
2,4-Dichlorophenoxy Acetic Acid as an Antidiabetic Drug: In silico, Preformulation and in vivo Approaches
Tamer Mohamed Shehata, Mohammed Abdou Khedr, Maged Elsayed Mohamed
pp. s79–s87 · DOI: 10.5530/ijper.54.2s.64 · Published 2020
Background: 2,4-Dichlorophenoxy acetic acid (2,4-D) was recently rediscovered as new anti-inflammatory agent through an in silico molecular modeling and in vivo anti-inflammatory inspection. Further computational investi…
Article
Design Development and Characterisation of Tramadol Hydrochloride Loaded Transethosomal Gel Formulation for Effective Pain Management
Vankayala Devendiran Sundar, Pamu Divya, Magharla Dasaratha Dhanaraju
pp. s88–s97 · DOI: 10.5530/ijper.54.2s.65 · Published 2020
Introduction: The purpose of the present study was to design develop and characterize the tramadol hydrochloride loaded transethosomal gel formulation for effective pain management. Materials and Methods: The transethoso…
Article
Development of Taste Masked Orodispersible Film Containing Paroxetine Hydrocloride
Swapnila Vivek Shinde, Shraddha Phatak, Ganesh Awale, Supriya Nikam
pp. s98–s107 · DOI: 10.5530/ijper.54.2s.66 · Published 2020
Aim and Objectives: The present study was to formulate and evaluate orodispersible films to overcome drawbacks of conventional dosage forms such as degradation by first-pass hepatic metabolism, decreased bioavailability …
Article
Development and Optimization of Naproxen Sodium Controlled Release Tablets: QbD Approach
Atul Phatak, Dhanashri Joshi, Mahesh Bhadgale, Pravin Chaudhari
pp. s108–s116 · DOI: 10.5530/ijper.54.2s.67 · Published 2020
Objectives: The aim of present study was to formulate and optimize Multi-unit Naproxen Sodium controlled release tablet by QbD approach. Controlled release dosage form for naproxen sodium was selected to reduce dosing fr…
Article
Formulation and Evaluation of Nisoldipine Loaded Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Application to Transdermal Delivery
Suddala Shirisha, Ankam Saraswathi, Sunit Kumar Sahoo, Yamsani Madhusudan Rao
pp. s117–s127 · DOI: 10.5530/ijper.54.2s.68 · Published 2020
Background: Nisoldipine is an anti hypertensive drug. Nisoldipine exhibits poor oral bioavailability (5%) because of rapid metabolism in the gut and liver. To overcome hepatic first pass metabolism and to enhance bioavai…
Article
Formulation and Evaluation of Asenapine Maleate Loaded Niosomes for the Treatment of Schizophrenia
Rudra Pratap Singh, Ramakant M Narke, Pooja V Jadhav
pp. s128–s139 · DOI: 10.5530/ijper.54.2s.69 · Published 2020
Background: Niosomes are the non-ionic surface-active agent primarily based vesicles. The Key obstacle of Asenapine maleate have oral bioavailability (<2%) and extensive first pass effect. Objectives: The objective key o…
Article
In vitro and in vivo Exploration of Super-magnetically Modulated Novel Parenteral Carrier: A Targeted Drug Delivery of Polymeric Carboplatin Nanosphere Capped with the Vitamin C to Treat Breast Cancer in Rats
Ullas Prakash D'Souza, Nitish Rao, Ravi Gundadka Shriram, Akhilesh Dubey
pp. s140–s153 · DOI: 10.5530/ijper.54.2s.70 · Published 2020
Introduction: Super-magnetically modulated nanosphere of carboplatin (CPt) capped with vitamin C and uncapped Nano sphere of CPt were developed and evaluated for their use as a targeted drug delivery system. Objectives: …
Article
Development of Thermosensitive Ophthalmic in situ Gels of Bimatoprost for Glaucoma Therapy
Sandeep Divate Sathyanarayana, Narayana Charyulu Rompicherla, Anoop Narayanan Vadakkepushpakath, Prashant Nayak
pp. s154–s162 · DOI: 10.5530/ijper.54.2s.71 · Published 2020
Background: In recent years, ophthalmic in situ gels have gained wide importance for the sustained delivery of drugs into the eye by overcoming the demerits of conventional eye drops. Objectives: The present investigatio…
Article
Development of Natamycin Loaded Glycerosomes–A Novel Approach to Defend Ophthalmic Keratitis
Priya Gupta, Rupa Mazumder, Swarupanjali Padhi
pp. s163–s172 · DOI: 10.5530/ijper.54.2s.72 · Published 2020
Objectives: Glycerosomes represent novel drug delivery systems and are characterised by addition of different amounts of glycerol to liposomal preparations. The present research work aims to formulate eyedrops of natamyc…
Article
Isoxsuprine Hydrochloride Loaded Cellulose Acetate Phthalate Microsponge Drug Delivery System: Design and Evaluation
Shubhangi Kagade, Jignasa Savjani, Dattatraya Yadav, Prashant Gurav
pp. s173–s181 · DOI: 10.5530/ijper.54.2s.73 · Published 2020
Aim: The present study was aimed to Design and evaluation of microsponge based drug delivery system of Isoxsuprine Hydrochloride. The microsponge drug delivery system is designed for site specific and controlled release …
Article
Synthesis and Characterization of Un-encapsulated and Pterostilbene-encapsulated DOTAP: Cholesterol Liposomes
Kaustubh Sunil Hiray, Suresh Palamadai Krishnan
pp. s182–s188 · DOI: 10.5530/ijper.54.2s.74 · Published 2020
Aim: Our study focuses on the liposome-based nanoformulation, which can encapsulate Pterostilbene for its subsequent testing in relevant, model systems for cancer. Background: Pterostilbene, a plant-derived, hydrophobic,…
Article
Lipid-Based Nano Formulation Approach to Target Brain for the Management of Tuberculosis through Intranasal Delivery: Formulation Development and Evaluation
Sai Surya Nikitha Upadhyayula, Raman Sureshkumar, S K Janani, Chenmala Karthika
pp. s189–s199 · DOI: 10.5530/ijper.54.2s.75 · Published 2020
Objectives: Development of nano-emulsion based drug delivery as combined drug loaded form for the possible management of meningitis. Intranasal delivery of nano-emulsion to the brain and study the nasal irritancy. Method…
Article
Formulation and in-vitro Evaluation of Oral Captopril Bioadhesive Delivery System
Mohamed Dawoud, Fahima Hashem
pp. s200–s209 · DOI: 10.5530/ijper.54.2s.76 · Published 2020
Background: Captopril is considered as the drug of choice in the treatment of hypertension and congestive heart failure. It has a very short duration of action and a biological half-life of 1-2 hr. This requires its admi…
Article
Xyloglucan Based Nasal in situ Gel Formulation of Mirtazapine for Treatment of Depression
Wadetwar Rita Naresh, Deshmukh Vaibhav Dilip, Kanojiya Pranita Sunil
pp. s210–s219 · DOI: 10.5530/ijper.54.2s.77 · Published 2020
Objectives: The objective of the present work was formulation of thermosensitive mucoadhesive in situ nasal gel of Mirtazapine for depression. The nasal route would overcome the first-pass effect and would enhance its ef…
Article
Supramolecular Complexes of Phospholipids and β-Cyclodextrin with Bioactive β-Carotene: A Comparative Physico-Chemical and Functional Evaluation
Saurabh Gujar, Darshan Telange, Anil Pethe
pp. s220–s229 · DOI: 10.5530/ijper.54.2s.78 · Published 2020
Background: β-carotene, a chief component of carotenoids family exhibits multiple numbers of pharmacological activities. However, its poor aqueous solubility and low dissolution rate restricts it to become a potential dr…
Article
Tenofovir Loaded Poly (Lactide-Co-Glycolide) Nanocapsules: Formulation Optimization by Desirability Functions Approach
Grandhi Srikar, Avula Prameela Rani
pp. s230–s240 · DOI: 10.5530/ijper.54.2s.79 · Published 2020
Background: Nanoparticles made of biodegradable polymers are the most effective colloidal drug delivery systems. The in vitro characteristics as well as in vivo presentation of these nanoparticles are majorly influenced …
Article
Comparison of Release Retardant Effect of Some Novel Lipids by Formulating Sustained Release Tablet of BCS Class 1 Drug
Rajni Devi, Ram Babu Sharma, Abhishek Sharma, Shweta Agarwal
pp. s241–s250 · DOI: 10.5530/ijper.54.2s.80 · Published 2020
Aim: The study was carried out with the objective of comparing the release retardant effect of some novel lipids by preparing sustained release tablets of highly watersoluble drug, theophylline. Methods: The tablets were…
Article
In vitro Anthelmintic Impact of Various Extracts of Pavetta tomentosa Root on Pheretima posthuma and in-silico Molecular Docking Evaluation of some Isolated Phytoconstituents
Dintakurthi Sree Naga Bala Krishna Prasanth, Siva Prasad Panda, Atmakuri Lakshmana Rao, Nayudu Teja, Veenam Bhavya Naga Vani, Tera Sandhya, Pathange Bharghava Bhushan Rao
pp. s251–s260 · DOI: 10.5530/ijper.54.2s.81 · Published 2020
Background: The current study assesses the anthelmintic impact of root extracts of Pavetta tomentosa on Pheretima posthuma compiled by molecular docking analysis of phytocompounds steemed from the plant with the β-Tubuli…
Article
In-vivo Screening of Ethanolic Extract of Antigonon leptopus Flower for Anti-diabetic and Antioxidant Potential
Satish Annayya Kavatagimath, Sunil Satyapa Jalalpure, Ravindra Durdundayya Hiremath, Amolkumar Ashok Kempwade
pp. s261–s268 · DOI: 10.5530/ijper.54.2s.82 · Published 2020
Objectives: Medicinal plants have always been a consummate source for drugs and already provided us with lead compounds for numerous currently available drugs with no or less side effects. This supports the usage of herb…
Article
Antifungal Nail Lacquer Loaded with Extract of Cissus quadrangularis for Treatment of Onychomycosis
Ashlesha Pravin Pandit, Amarnath Arunrao Kedar, Suvidya Vilas Ranaware, Kishanchandra Radheshyam Khandelwal
pp. s269–s276 · DOI: 10.5530/ijper.54.2s.83 · Published 2020
Objectives: An attempt was made to prepare transparent nail lacquer containing natural antifungal agent obtained from extract of whole plant of Cissus quadrangularis for the treatment of onychomycosis. Methods: The extra…
Article
Effect of Gymnema sylvestre on Insulin Receptor (IR) and Proglucagon Gene Expression in Streptozotocin Induced Diabetic Rats
Eswar Kumar Kilari, Swathi Putta, Kotaiah Silakabattini
pp. s277–s284 · DOI: 10.5530/ijper.54.2s.84 · Published 2020
Aim: To study the expression of Insulin Receptor (IR) in pancreas and proglucagon in the ileum homogenate with the hydroalcoholic extract of Gymnema sylvestre (HAGS) in streptozotocin induced diabetic rats. Materials and…
Article
Neuroprotective Effects of Licorice Extracts in Tibial and Sural Transection Induced Neuropathic Pain in Rats
Tanmayee Amit Joshi, Pratima Tatke
pp. s285–s294 · DOI: 10.5530/ijper.54.2s.85 · Published 2020
Background: Neuropathic pain (NP) is the worst of tortures, a nerve wound may experience as a result of nerve damage or complication of diabetes/HIV/cancer. There are no defined guidelines for treatment. Available treatm…
Article
In-vitro Cytotoxicity and in silico Molecular Docking of Alkaloids from Tiliacora acuminata
Jeswiny Rodrigues, Kirankumar Hullatti, Sunil Jalalpure, Pukar Khanal
pp. s295–s300 · DOI: 10.5530/ijper.54.2s.86 · Published 2020
Background: The present study aimed to identify the cytotoxicity of Tiliacora acuminata extract/fraction(s) plant via bioactivity guided approach and predict the binding affinity with Topoisomerase II. Materials and Meth…
Article
Bioassay-Guided Fractionation of Endophytic Fungal Extract of Fusarium solani (Saccardo) against Cancer Cell Lines and Zebrafish Embryo
Nael Mahmoud Abutaha, Muhammed Farooq Farooq, Fahd Ali Nasr, Fahd Abdu Ahmed Almekhlafi, Muhammad Wadaan
pp. s301–s308 · DOI: 10.5530/ijper.54.2s.87 · Published 2020
Background: This study aimed to explore the toxicity and apoptotic potential of Fusarium solani extracts on cancer cell lines and zebrafish embryo. Materials and Methods: F. solani was initially extracted with ethyl acet…
Article
New Bioactive Molecules Isolated for the First Time from Hyoscyamus albus L. and their Mechanisms Underlying the Anticancer Effects
Massinissa Yahia, Afaf Benhouda, Mouloud Yahia, Hamada Haba, Francisco Campos, Souhila Benbia, Antonio Rangel
pp. s309–s315 · DOI: 10.5530/ijper.54.2s.88 · Published 2020
Background: Hyoscyamus albus L is a small genus from Solanaceae family known by its use in old traditional medicine in the east of Algeria. Aim: This study aimed to characterize new bioactive molecules from H. albus, eva…
Article
Structural Elucidation of Isolated Phytochemicals from Selected Medicinal Plants with Antihyperlipidemic Activity and Development of Polyherbal Formulation with Densitometric Analysis of Isolated Phytoconstituents
Deepa Iyer, Umesh K Patil
pp. s316–s329 · DOI: 10.5530/ijper.54.2s.89 · Published 2020
Objectives: The present systematic research aimed to express the antihyperlipidemic effects of different types of herbs based on animal studies. The purpose of the present project is to perform the phytochemical investig…
Article
Total Synthesis of Clausenain, a Cyclic Octapeptide and its Analog for Anticancer Activity
Nirmala Shinde, Avinash Shridhar Dhake, Kishan Prabhu Haval, Sachin Kawaduji Bhosale
pp. s330–s336 · DOI: 10.5530/ijper.54.2s.90 · Published 2020
Keeping in mind requisite of today’s era for development of new anticancer drugs, synthesis of a phenyl alanine rich cyclic octapeptide Clausenain and its analog by solution phase technique is described here. It was done…
Article
Ultraviolet-visible Spectrophotometric Method for Estimation of Gliclazide in Presence of Excipients Interacting in UV-visible Region
Neelkant Prasad, Aditya Sharma
pp. s337–s343 · DOI: 10.5530/ijper.54.2s.91 · Published 2020
A simple and sensitive ultraviolet spectrophotometric method for quantitative estimation of a model API gliclazide in presence of excipients is described to avoid false estimation due to presence of soluble or insoluble …
Article
Development and Validation of Novel Stability- Indicating LC Method for the Determination of Saxagliptin and Metformin
Sachin Bhanudas Gurav, Neela Manish Bhatia
pp. s350–s357 · DOI: 10.5530/ijper.54.2s.93 · Published 2020
Aim: Development of a novel precise, selective and sensitive stability indicating RPHPLC method has been developed and validated for the determination of Saxagliptin hydrochloride (SAX) and Metformin HCl (MET) in bulk dr…
Article
Development and Validation of a Simultaneous Bioanalytical Method for Methotrexate, Sulfasalazine and Hydroxychloroquine in Rat Plasma following Single Step Protein Precipitation Technique
Pichili Ajitha Reddy, Amit Kumar Sahu, Manish Kumar Sharma, Pinaki Sengupta
pp. s358–s367 · DOI: 10.5530/ijper.54.2s.94 · Published 2020
Background: Triple therapy of methotrexate, sulfasalazine and hydroxychloroquine is widely used in the treatment of rheumatoid arthritis. Different studies reported the superior efficacy of combination of these three dru…
Article
Simultaneous RP-HPLC Quantification of Four Phenolics in Elephantopus scaber L. and their in vitro Pharmacological Validation
Pushpendra Kumar Shukla, Ankita Misra, Bhanu Kumar, Abhishek Niranjan, Sharad Srivastava
pp. s368–s373 · DOI: 10.5530/ijper.54.2s.95 · Published 2020
Elephantopus scaber (L.) is a widely used traditional medicinal plant, grows in hotter parts of the Indian subcontinent, Tropical Africa and East Asia. The present study was aimed RPHPLC quantification of phenolics and i…
Article
Clot Buster Enzyme Activity from Bacillus sp.,
Mohanasrinivasan Vaithiyalingam, Subin Jacob Chacko, Nivetha Anbalagan, Jannatul Firdous Siddique
pp. s374–s380 · DOI: 10.5530/ijper.54.2s.96 · Published 2020
Context: Clot buster enzyme is widely used as the thrombolytic agent due to its low cost as compared to several other thrombolytic agents. Aim: The aim of the study is to isolate clot buster enzyme producing bacteria fro…