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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Isoxsuprine Hydrochloride Loaded Cellulose Acetate Phthalate Microsponge Drug Delivery System: Design and Evaluation

Shubhangi Kagade1★, Jignasa Savjani2, Dattatraya Yadav2, Prashant Gurav3★ Corresponding author

  1. 1Department of Pharmaceutics, SVERI’s College of Pharmacy, Pandharpur, Maharashtra, INDIA.
  2. 2Department of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, INDIA.
  3. 3Department of Pharmaceutics, Indira Institute of Pharmacy, Sadavali, Ratnagiri, Maharashtra, INDIA.

CORRESPONDENCE

Shubhangi Kagade

Department of Pharmaceutics, SVERI’s College of Pharmacy, Pandharpur, Maharashtra, INDIA.

shubhangi24kagade@gmail.com

Received: 21-09-2019; Revised: 26-12-2019; Accepted: 12-03-2020.

Volume 54, Issue 2S · pp. s173–s181 · PUBLISHED 2020 · DOI: 10.5530/ijper.54.2s.73

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ABSTRACT

Aim: The present study was aimed to Design and evaluation of microsponge based drug delivery system of Isoxsuprine Hydrochloride. The microsponge drug delivery system is designed for site specific and controlled release of drug by using cellulose acetate phthalate to improve the site-specific absorption of drug. Materials and Methods: The microsponges was formulated by modified quasi emulsion solvent diffusion technique. The chemical interaction between Isoxsuprine Hydrochloride, cellulose acetate phthalate, ethyl cellulose and polyvinyl pyrrolidone was studied by FTIR, the results of FTIR it was confirmed that there were no chemical reaction in between drug and polymer. The compatibility study of drug and polymer were confirmed by DSC. Results: The results of FTIR it was confirmed that there were no chemical reaction in between drug and polymer. The in vitro drug release found in between range of 91.97% to 98.78% the highest % CDR was shown by formulation MS5. The optimized formulation (MS5) demonstrated favorable % entrapment efficiency (93.6%), % buoyancy (78%) and % cumulative drug release (98.78%). SEM revealed the release of Isoxsuprine Hydrochloride in controlled release pattern from spherical and porous microsponges. Conclusion: This study provides a new approach to formulate and evaluate the microsponges of Isoxsuprine Hydrochloride for treatment of premature labor during pregnancy.

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    Kagade, S., Savjani, J., Yadav, D., & Gurav, P. (2020). Isoxsuprine Hydrochloride Loaded Cellulose Acetate Phthalate Microsponge Drug Delivery System: Design and Evaluation. Indian Journal of Pharmaceutical Education and Research, 54(2S), s173–s181. https://doi.org/10.5530/ijper.54.2s.73