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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Formulation and Evaluation of Cefixime Nanosuspension for the Enhancement of Oral Bioavailability by Solvent-Antisolvent Method and its Suitable Method Development

Vinayak Shivamurthi Mastiholimath1, Bhagat Ankita Rajendra1★, Vinodkumar Shirshalappa Mannur1, Panchaxari Mallappa Dandagi2, Anand Panchaxari Gadad2, Pukar Khanal3★ Corresponding author

  1. 1Department of Pharmaceutical Quality Assurance, KLE College of Pharmacy-Belagavi, KLE Academy of Higher Education and Research (KAHER) Belagavi, Karnataka, INDIA.
  2. 2Department of Pharmaceutics, KLE College of Pharmacy-Belagavi, KLE Academy of Higher Education and Research (KAHER) Belagavi, Karnataka, INDIA.
  3. 3Department of Pharmacology and Toxicology, KLE College of Pharmacy-Belagavi, KLE Academy of Higher Education and Research (KAHER) Belagavi, Karnataka, INDIA.

CORRESPONDENCE

Bhagat Ankita Rajendra

Department of Pharmaceutical Quality Assurance, KLE College of Pharmacy-Belagavi, KLE Academy of Higher Education and Research (KAHER) Belagavi, Karnataka, INDIA.

ankivb99@gmail.com

Received: 17-05-2019; Revised: 04-09-2019; Accepted: 07-11-2019.

Volume 54, Issue 1 · pp. 55–67 · PUBLISHED 2020 · DOI: 10.5530/ijper.54.1.7

View on IJPER original site ↗

ABSTRACT

Aim: The objective of the present study was to develop and evaluate cefixime nanosuspension to enhance its oral bioavailability. Materials and Methods: The method used was solvent/ antisolvent method in which methanol and Millipore water was used as solvent and antisolvent respectively. The surfactants used for the preparation were PVP K30 and HPMC K100 which was found to be compatible in the formulation. Compatibility of the drug and drug with its excipients was found out by FTIR studies. Characterization of the optimized Cefixime Nanosuspension was carried out by particle size analysis, Differential Scanning Calorimetry, Zeta Potential, Drug content, in-vitro drug release studies, Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy(TEM). The antimicrobial activity of cefixime nanosuspension was done by Disk diffusion method against E. coli performed in nutrient agar with different concentrations of the formulation. The Minimum Inhibitory Concentration (MIC) was determined by calculating Zone of inhibition. A method was developed forcefixime nanosuspension and validated by High Performance Thin Layer Chromatography (HPTLC). Results: The optimizedcefixime nanosuspension was validated for Identification, Linearity, Specificity, Precision and Recovery. The Recovery of cefixime nanosuspension was found to be 95.57%.

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    Mastiholimath, V. S., Rajendra, B. A., Mannur, V. S., Dandagi, P. M., Gadad, A. P., & Khanal, P. (2020). Formulation and Evaluation of Cefixime Nanosuspension for the Enhancement of Oral Bioavailability by Solvent-Antisolvent Method and its Suitable Method Development. Indian Journal of Pharmaceutical Education and Research, 54(1), 55–67. https://doi.org/10.5530/ijper.54.1.7