Effect of Vanillic Acid on Nerve Conduction Velocity in Chronic Constriction Injury Model of Neuropathy

ABSTRACT

Background: Neuropathic Pain (NP) is less or symptomatically managed by presently available therapeutics. Therefore developing more effective drugs with minimum adverse effects is essential. Vanillic acid is phenolic secondary plant metabolite. Extensive research regarding phenolic acids with antioxidant, free radical scavenging and neuroprotective roles have been published. Objectives: The aim of this undertaken study was to evaluate the efficacy of vanillic acid (V.A.) to improve nerve conduction velocity in neuropathic pain induced by CCI (chronic constriction injury) and to evaluate its antioxidant potential. Methods: Rats were divided into 7 groups (n=6), as negative control, positive control (CCI), sham control, CCI+gabapentin (300 mg/kg, p.o.), V.A. (25 mg/kg, p.o.), V.A. (50 mg/kg, p.o.) and V.A. (100 mg/kg, p.o.). After surgery oxytetracycline (25 mg/kg, i.m.) was administered in animals to avoid any infection. Vanillic acid and gabapentin administered post-surgery from day 4th till 28th day. Velocity of nerve conduction and antioxidant and histopathological studies were conducted on 28th day. Results: Repeated oral administration of vanillic acid (50 mg/kg, 100 mg/kg) significantly improved MNCV. V.A. showed antioxidant property by significantly elevating level of GSH and also reversed histopathological changes induced by CCI. Conclusion: This study has suggested antioxidant and neuroprotective effect of vanillic acid in CCI induced peripheral neuropathy.

KEYWORDS

• CCI
• MNCV
• Neuropathy
• Gabapentin
• Vanillic acid

Showing references and in-text citations exactly as published.

• DOI10.5530/ijper.54.1.13Copy

RELATED ARTICLES

Matched on section and article type within this issue of IJPER.

• Article · VOLUME 54, ISSUE 1Emerging Non-Pharmacological Therapies for Post-stroke Depression and its Future Aspects: A ReviewKeerthana Chandrasekar, Nakka Gautam Sai, Princy Sabu John, Sruthi Ninan, Raja Durai, Sivasankaran Ponnusankar · pp. 1–7Original ArticleSame type: Article
• Article · VOLUME 54, ISSUE 1Treatment of Osteoporosis: Current Scenario from a Research PerspectivePooja Umesh Pherwani, Sadhana Sathaye · pp. 8–16Original ArticleSame type: Article
• Article · VOLUME 54, ISSUE 1Calculating and Evaluating of the Achievements of Pharmaceutical Separation Engineering Course for Pharmaceutical Engineering Major Based on Engineering Education CertificationHua Li, Xiaohua Shi · pp. 17–21Original ArticleSame type: Article
• Article · VOLUME 54, ISSUE 1Preconception of Pharmacy Students for the Inclusion of Entrepreneurship Curriculum in the PharmD ProgramAhmed Abdelrahman Albarraq, Hafiz Antar Makeen, David Banji · pp. 22–30Original ArticleSame type: Article