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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Formulation and Evaluation of Tamoxifen Citrate Loaded Transdermal Reservoir Gel Drug Delivery Systems

Nagaraja SreeHarsha1,4★, Jagadeesh G Hiremath4, Bimlesh Kumar Rawre2, Niranjan Puttaswamy5, Bandar E Al-Dhubiab1, Katharigatta N. Venugopala1,3, Sabah H Akrawi1, Girish Meravanige5, Mahesh Attimarad1, Anroop B Nair1★ Corresponding author

  1. 1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  2. 2Department of Pharmaceutics, East West College of Pharmacy, Bengaluru, Karnataka, INDIA.
  3. 3Department of Biotechnology and Food Technology, Durban University of Technology, Durban, SOUTH AFRICA.
  4. 4Department of Pharmaceutics, Vidya Siri College of Pharmacy, Bangalore, Karnataka, INDIA.
  5. 5Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.

CORRESPONDENCE

Nagaraja SreeHarsha

Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.

sharsha@kfu.edu.sa

Received: 14-05-2019; Revised: 29-06-2019; Accepted: 10-08-2019.

Volume 53, Issue 4S · pp. s596–s606 · PUBLISHED 2019 · DOI: 10.5530/ijper.53.4s.155

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ABSTRACT

Background: Successful treatment of cancer is yet remained as a challenging concern in public health. Transdermal delivery of hormonal therapy offers several advantages over the oral route associated with potential side effects. Methods: The present investigation preparation and screening of rate controlling membranes using Eudragit release liners of RS 100, hydroxyl propyl methyl cellulose K4M (HPMC K4M) and ethyl cellulose by plate casting method and their physicochemical characterization. The prepared release liners were subjected for preformualtion studies (thickness, weight variation, moisture uptake, folding endurance and moisture loss). Tamoxifen citrate is an ideal molecule for the transdermal reservoir for the preparation of gel dosage form due its dosage regimen. Results: The main investigation, topical gel TC was prepared using HPMC K4M and Carbopol 934 as gelling agents in different proportions with Dimethyl Sulfoxide (DMSO) as a penetration enhancer. TC gels were subjected for the physicochemical parameters such as pH, viscosity, spreadability. Conclusion: The TC gel diffusion was conducted by using rate controlling membranes (release liner). The TC gel skin permeation was investigated by using excised rat skin as a barrier.

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    SreeHarsha, N., Hiremath, J. G., Rawre, B. K., Puttaswamy, N., Al-Dhubiab, B. E., Venugopala, K. N., Akrawi, S. H., Meravanige, G., Attimarad, M., & Nair, A. B. (2019). Formulation and Evaluation of Tamoxifen Citrate Loaded Transdermal Reservoir Gel Drug Delivery Systems. Indian Journal of Pharmaceutical Education and Research, 53(4S), s596–s606. https://doi.org/10.5530/ijper.53.4s.155