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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Potential Effect of Steroidal Alkaloids from Sarcococca saligna against Leishmania tropica

Naeem Ullah Jan1★, Bashir Ahmad2, Muhammad Kifayatullah1, Haroon Rahim1, Fazli Amin1★ Corresponding author

  1. 1Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, PAKISTAN.
  2. 2Centre of Biotechnology and Microbiology, University of Peshawar, Peshawar, PAKISTAN.

CORRESPONDENCE

Naeem Ullah Jan

Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, PAKISTAN.

numan2001@hotmail.com

Received: 09-07-2019; Revised: 27-09-2019; Accepted: 04-10-2019.

Volume 53, Issue 4S · pp. s650–s654 · PUBLISHED 2019 · DOI: 10.5530/ijper.53.4s.161

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ABSTRACT

Background and Objectives:Sarcococca species have a rich source of steroidal alkaloids that possess different biological and pharmacological activities. Hence, present research was design to isolate the steroidal alkaloid from Sarcococca saligna and to evaluate it for in-vitro antileishmanial activity. Materials and Methods: Compound Holaphylline and Saracodine were isolated through column chromatography followed by spectroscopic techniques for elucidation and were assayed against promastigotes of Leishmania tropica. Results: Saracodine compound eliminates 71.12%, 63.9%, 54.18% and 38.88% of the promastigotes at concentration 100 µM; 75 µM, 50 µM and (25 µM). While, the elimination of promastigotes with compound holaphylline were 82.5%, 76.68%, 65%, 47.22% respectively as compared to untreated group. Conclusion: In present study, compound Holaphylline and Saracodine exhibited inhibition against the promastigotes and justified the claimed medicinal importance of Sarcococca saligna as a remedy for leishmaniasis especially against Leishmania tropica.

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    Jan, N. U., Ahmad, B., Kifayatullah, M., Rahim, H., & Amin, F. (2019). Potential Effect of Steroidal Alkaloids from Sarcococca saligna against Leishmania tropica. Indian Journal of Pharmaceutical Education and Research, 53(4S), s650–s654. https://doi.org/10.5530/ijper.53.4s.161