jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Quantitative Analysis of Pantoprazole Sodium Sesquihydrate in Bulk and Solid Dosage Form via UV-Spectrophotometric Method

Asma Rafiq1, Somia Gul1, Arzoo Ajaz1, Sakina Fatima2, Agha Zeeshan Mirza3,4★★ Corresponding author

  1. 1Faculty of Pharmacy, Jinnah University for Women, Karachi, PAKISTAN.
  2. 2Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi, PAKISTAN.
  3. 3Research Laboratories Centre, Faculty of Applied Sciences, Umm Al Qura University, Makkah, SAUDI ARABIA.
  4. 4Department of Chemistry, Faculty of Applied Sciences, Umm Al Qura University, Makkah, SAUDI ARABIA.

CORRESPONDENCE

Agha Zeeshan Mirza

Research Laboratories Centre, Faculty of Applied Sciences, Umm Al Qura University, Makkah, SAUDI ARABIA.

drsomi1983@yahoo.com

Received: 20-07-2019; Revised: 05-11-2019; Accepted: 23-12-2019.

Volume 54, Issue 2 · pp. 448–455 · PUBLISHED 2020 · DOI: 10.5530/ijper.54.2.51

View on IJPER original site ↗

ABSTRACT

Pantoprazole sodium sesquihydrate, is a proton pump inhibitor, was analyzed by using UV spectrophotometry. The quantification of pantoprazole sodium sesquihydrate in distilled water was performed in the wavelength range of 290 nm at 20 μgmL-1. The linearity range is 5-35 μgmL-1 by using UV spectrophotometry. The developed method was applied directly and easily to the analysis of the pantoprazole sodium sesquihydrate in bulk and pharmaceutical tablet preparations. The developed method was completely validated according to ICH guidelines. The accuracy of the developed method was calculated in terms of percentage recovery (99.20-101.21%) and %RSD values less than 1% were found in precision. The LOD and LOQ were 0.989 and 1.954 μgmL-1, respectively. Because of simplicity, accuracy and cost-effectiveness, this validated method is helpful for a daily laboratory analysis of pantoprazole sodium sesquihydrate.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Rafiq, A., Gul, S., Ajaz, A., Fatima, S., & Mirza, A. Z. (2020). Quantitative Analysis of Pantoprazole Sodium Sesquihydrate in Bulk and Solid Dosage Form via UV-Spectrophotometric Method. Indian Journal of Pharmaceutical Education and Research, 54(2), 448–455. https://doi.org/10.5530/ijper.54.2.51