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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Fabrication of Poly (Sebacic acid-co-ricinoleic-ester anhydride) with β-cyclodextrin-loaded Doxorubicin Implants and in vitro Characterization

Nagaraja Sreeharsha1,9★, Jagadeesh G Hiremath2, Bandar E Al-Dhubiab1, Girish Meravanige3, Ranjith Kumar Karnati4, Mahesh Attimarad1, Anroop B Nair1, Katharigatta N Venugopal1,10, Mohamed A Morsy1,8, Shinu Pottathil5, Saleemmulla Khan6, Nagashekhara Molugulu7★ Corresponding author

  1. 1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  2. 2Department of Pharmaceutics, PA College of Pharmacy, Mangalore, Karnataka, INDIA.
  3. 3Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  4. 4Department of Chemistry, College of Science, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  5. 5Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  6. 6Department of Pharmacognosy, PA College of Pharmacy, Mangalore, Karnataka, INDIA.
  7. 7School of Pharmacy, Monash University, Jalan Lagoon Selatan, Bandar Sunway, Selangor, MALAYSIA.
  8. 8Department of Pharmacology, Faculty of Medicine, Minia University, El-Minia 61511, EGYPT.
  9. 9Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, INDIA.
  10. 10Department of Biotechnology and Food Technology, Durban University of Technology, Durban, SOUTH AFRICA.

CORRESPONDENCE

Nagaraja Sreeharsha

Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.

sharsha@kfu.edu.sa

Received: 29-02-2020; Revised: 30-03-2020; Accepted: 30-03-2020.

Volume 54, Issue 3 · pp. 826–834 · PUBLISHED 2020 · DOI: 10.5530/ijper.54.3.135

View on IJPER original site ↗

ABSTRACT

Background: Doxorubicin is an excellent molecule for the formation of biodegradable implants using the poly (sebacic acid-co-ricinoleic-ester anhydride) 70:30 w/w (poly[SARA] 70:30 w/w PSRA 7/3) polymer. Methods: The cylindrical implants were successfully produced by means of hot melt extrusion. We used differential scanning calorimetric (DSC) and X-ray diffraction (XRD) methods to identify the melting state and crystal type of blank and drug-loaded implants. A study was conducted on PSRA 7/3 w/w blank and drug-loaded implants for in vitro hydrolytic degradation. The drug present in the remaining sample was estimated. Results: The hydrolytic degradation rate of the 10% w/w (F2)-loaded implant was relatively low when compared with the 20% w/w (F3) implant. Discussion: In vitro drug release studies illustrated that the drug-release rate was faster in association with increasing amounts of doxorubicin in the implant.

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    Sreeharsha, N., Hiremath, J. G., Al-Dhubiab, B. E., Meravanige, G., Karnati, R. K., Attimarad, M., Nair, A. B., Venugopal, K. N., Morsy, M. A., Pottathil, S., Khan, S., & Molugulu, N. (2020). Fabrication of Poly (Sebacic acid-co-ricinoleic-ester anhydride) with β-cyclodextrin-loaded Doxorubicin Implants and in vitro Characterization. Indian Journal of Pharmaceutical Education and Research, 54(3), 826–834. https://doi.org/10.5530/ijper.54.3.135