Volume 54, Issue 3

Is Covid-19 Sibling of SARS and MERS? A Review on: Novel Covid-19

Savita Devi, Kamaldeep Singh

pp. 491–495 · DOI: 10.5530/ijper.54.3.97 · Published 2020

Pandemic times: Contemporary public health catastrophe terrifying the world over with the rapidly spreading of 2019-nCoV or SARS-CoV-2. Coronaviruses have pass over the species barriers to cause fatal disease in human si…

Therapeutic Potential of Chymase Inhibitors in Cardiovascular Diseases: An Overview

Qutaiba Ahmed Al Khames Aga, Anroop B. Nair, Wafa Hourani, Subramani Parasuraman, Mueen Ahmed KK, Nagaraja Sreeharsha

pp. 509–516 · DOI: 10.5530/ijper.54.3.99 · Published 2020

Chymase belongs to the family of serine proteases and is mainly warehoused in a heparin proteoglycan macromolecular complex within the mast cells. Extensive studies have been carried out in the last few decades to assess…

Pharm D Program: Is it Necessary in BRICS?

Pei Yu, Beverley Joy Wilson, Amy Claire Bobbins, Sunitha Chandrasekhar Srinivas, Gang Yin

pp. 517–525 · DOI: 10.5530/ijper.54.3.100 · Published 2020

The various trajectories of the development of the Doctor of Pharmacy (Pharm D) programs in BRICS countries were reviewed individually, showing the progress of Pharm D programs in each context. Evidence from developed co…

Biomaterials in 3D Printing: A Special Emphasis on Nanocellulose

Ravindra Vijay Badhe, Anagha Godse, Ankita Ahinkar

pp. 526–540 · DOI: 10.5530/ijper.54.3.101 · Published 2020

Aim and Background: The main objective of this review is to highlight nanocellulosic materials in 3D bioprinting. Three-dimensional (3D) bioprinting is on the verge of fabricating the artificial organ and living tissues.…

Novel Oral Drug Delivery Systems for Steroids: Overview and Recent Updates

Manikanta Sai Ganapa, Saurabh Shekhar Mhatre, Sushil Yadaorao Raut, Abhijeet Pandey, Guruprasad Kalthur, Srinivas Mutalik

pp. 541–549 · DOI: 10.5530/ijper.54.3.102 · Published 2020

This review summarises the oral route of drug delivery of steroids. Oral drug delivery is widespread owing to its non-invasive nature which complements high patient compliance. This article summarises the problems associ…

Fast HPLC-DAD Method for Estimation of Catechin for Standardization of Extracts and Antiasthmatic Polyherbal Formulations Containing Albizia lebbeck

Sonal Desai, Pratima Tatke, Vinay Gaitonde, Satish Gabhe

pp. 550–555 · DOI: 10.5530/ijper.54.3.103 · Published 2020

Background: Many marketed polyherbal formulations containing Albizia lebbeck are available for treatment of allergic disorders such as asthma and bronchitis. But these formulations are not standardized in terms of marker…

The Efficacy of PBL Model in Pathology and Pathophysiology Teaching in China: A Meta-analysis

Jianguo Hu, Xiaojing Hu, Zhengyue Shan, Rui Wang

pp. 556–564 · DOI: 10.5530/ijper.54.3.104 · Published 2020

Purpose: To systematically evaluate the effect of PBL in Pathology and Pathophysiology teaching. Approach: CNKI, PubMed, WanFang Data, EMbase databases were electronically searched to collect randomized controlled trials…

Correlation between Academic Evaluation Scores within the Undergraduate Medical Education: A Cross-sectional Study

Nur Atik, Devina Talitha, Resti Gradia Dwiwina, Afiat Berbudi, Nur Melani Sari, Putu Indra Cyntia Dewi, Nada Ristya Rahmani

pp. 565–571 · DOI: 10.5530/ijper.54.3.105 · Published 2020

Introduction: There are several evaluations to assess the medical students finishing the courses. Examinations could be multiple-choice questions that tend to evaluate the memorization rather than analytical ability. Ano…

The First Objective Structured Practical Examination (OSPE) in Pharmacy Teaching in Poland: Designing, Implementing and Assessing the Results

Justyna Dymek, Tomasz Kowalski, Anna Gołda, Wioletta Polak, Agnieszka Skowron

pp. 572–579 · DOI: 10.5530/ijper.54.3.106 · Published 2020

Background: Education of pharmacy students in preparation for their profession is still changing. It is therefore important to improve students’ skills necessary to provide pharmaceutical services according to the profes…

A Learner Centered Approach of Teaching and Learning in Pharmacology: A Questionnaire Based Analysis of Student Cognizance and Experiences

Rashmi Raghava Rao, Preethi Jnaneshwara Shenoy, Sheetal Dinakar Ullal, Ashwin Kamath

pp. 580–588 · DOI: 10.5530/ijper.54.3.107 · Published 2020

Background: Innovative and flexible educational methods like Problem Based Learning (PBL) and integrated teaching practices were integrated into the Pharmacology course in a manner that they complement the didactic lectu…

Bioavailability and Dissolution Rate Enhancement of an Anticancer Drug Bicalutamide by Encapsulation into Mesoporous Silica Nanoparticles: Effects of Amine Functionalization and Caco-2 Cell Permeability Study

Seema Saroj, Sadhana Rajput

pp. 589–601 · DOI: 10.5530/ijper.54.3.108 · Published 2020

Background: The present study was undertaken with the aim of dissolution rate and Bioavailability enhancement of anticancer drug Bicalutamide (BIC) via encapsulation into mesoporous silica nanoparticles (MSNs). Materials…

Solvent Drop Grinding Approach Assisted Development of Glimepiride Co-crystals: Solubility Enhancement Journey of BCS Class-II Product

Santosh Subhash Chhajed, Yatish Rajendra Rajderkar, Anjali Baburao Tajanpure, Jaiprakash Navnath Sangshetti, Debarshi Kar Mahapatra, Sanjay Jayprakash Kshirsagar

pp. 602–609 · DOI: 10.5530/ijper.54.3.109 · Published 2020

Background: Glimepiride has limited aqueous solubility and majorly suffers from bioavailability issues that eventually reduce the pharmacotherapeutic potentials of the moiety. Materials and Methods: For the possible augm…

Fabrication and Characterization of Chitin Hydrogel Nano Silver Fused Scaffold for Wound Dressing Applications

Nagalakshmi Sethuraman, Bhavishi Gokuldoss, Anusha Murugesan, Asha Mani, Abdul Gani, Shanmuganathan Seetharaman

pp. 610–617 · DOI: 10.5530/ijper.54.3.110 · Published 2020

Aim/Background: A scaffold is a wound dressing material which can be fabricated in the shape of the tissue that we want to restore in our body depending upon their structural and functional requirements. Chitin is the ca…

Development and Evaluation of Unidirectional Mucoadhesive Bio-Flexy Films Loaded with Nanosized Topiramate using a Novel Biopolymer from Glycine max

Sugandha Varshney, N V Satheesh Madhav

pp. 618–629 · DOI: 10.5530/ijper.54.3.111 · Published 2020

Aim: Formulation and evaluation of nanosized Topiramate loaded bio-flexy films using novel biopolymer isolated from Glycine max seeds for epilepsy treatment. Methods: Formulations containing nanosized Topiramate: Glycine…

Molecular Interaction of Polymer Dextran in Sodium Hydroxide through Evaluation of Thermo Acoustic Parameters

Subhraraj Panda

pp. 630–636 · DOI: 10.5530/ijper.54.3.112 · Published 2020

Aim: To find out the molecular interaction of solute dextran of different concentration with sodium hydroxide as a solvent. Materials: Dextran of molecular weight 70000 dalton and aqueous 1(N) Sodium hydroxide. Methods: …

Mupirocin Mounted Copper Nanoparticle Offered Augmented Drug Delivery against Resistant Bacteria

Vikram Verma, Dinesh Kaushik

pp. 637–646 · DOI: 10.5530/ijper.54.3.113 · Published 2020

Aim: In present investigation, mupirocin coupled copper nanoparticles were synthesized to overwhelm drug resistance in Staphylococcus aureus, responsible for dermal skin infections. Materials and Methods: Mupirocin (Ancl…

Application of Similarity Factor (f2) and Time Required to Drug Release (t%) Indicators for Dissolution Profiles Comparison of Paracetamol Tablets

Farrukh Zeeshan, Phang Yee Lin, Ravi Sheshala

pp. 647–653 · DOI: 10.5530/ijper.54.3.114 · Published 2020

Introduction: The comparison of in vitro dissolution profiles is an integral step during the development of any generic product. However, using merely similarity factor (f2) as a dissolution parameter may not be adequate…

Commiphora mukul and Quercetin Loaded Liposphere Gel: Potential Treatment for Psoriasis

Madhura Mestry, Meenal Rane, Amrita Bajaj

pp. 654–667 · DOI: 10.5530/ijper.54.3.115 · Published 2020

Background: Psoriasis is a chronic autoimmune skin disorder characterized by thick skin patches, which are typically red, scaly and itchy. Topical drug delivery is backbone in mild and moderate psoriasis as well as usefu…

Apigetrin Inhibits Thyroid Cancer Cell Growth and Proliferation through Down-Regualtion of HIF1α and VEGF Expression

Zhihua Guo, Yuan Xing, Wei Wang, Jingbo Lai

pp. 668–673 · DOI: 10.5530/ijper.54.3.116 · Published 2020

Aim: Thyroid cancer is a commonly detected endocrine malignant tumour which accounts for 1% of the total human cancers. The present study was aimed to investigate the effect of apigetrin on anaplastic thyroid cancer cell…

Naringin Attenuates Aluminum Induced Cognitive Deficits in Rats

pp. 674–681 · DOI: 10.5530/ijper.54.3.117 · Published 2020

Aim: The exposure of aluminum for longer period in brain can lead to impaired cognition and behavioral changes. The present study was aimed to investigate the aluminum induced cognitive deficits and possible protective o…

Exploring the Role and Mechanism of Imatinib in Chronic Unpredictable Mild Stress-induced Depression Model of Rats

Xiaohui Wang, Yajing Li, Yinxue Shen, Dongzi Zhang

pp. 682–689 · DOI: 10.5530/ijper.54.3.118 · Published 2020

Aim: The study was planned to examine the potential effect of imatinib in chronic unpredictable mild stress (CUMS)-induced depression model of rats. Materials and Methods: Male rats were subjected to the 6-week CUMS with…

Role of Heme Oxygenase- 1(HO-1) and Endothelin-1 (ET-1) in Modulation of Cardioprotective Effect of Ischemic Postconditioning in Diabetic Rat Heart

Richa Rohilla, Ahsas Goyal, Vibhav Varshney, Bhupesh Chander Semwal, Harlokesh Narayan Yadav

pp. 690–697 · DOI: 10.5530/ijper.54.3.119 · Published 2020

Background: We have recently reported that heme oxygenase-1 (HO-1) is involved in ischemic preconditioning-mediated cardioprotection by promoting nitric oxide (NO) release into diabetic rat heart (DRH). The upregulation …

Nostocine A Derivatives as Human DNA Topoisomerase II-alpha Inhibitor

Chita Ranjan Sahoo, Sudhir Kumar Paidesetty, Rabindra Nath Padhy

pp. 698–704 · DOI: 10.5530/ijper.54.3.120 · Published 2020

Introduction: Due to heavy morbidity and mortality from cancer, the designing of newer drugable molecules against breast cancer is the call of day. As, Schiff-base sulfonamides have been widely used in tumor treatments. …

Bioactivity Guided Antidiabetic Formulation Development of Tridax procumbens Linn Leaves

Pranali Vijay Bansode, Kiran Shivaji Patil, Ashok Ananda Hajare

pp. 705–713 · DOI: 10.5530/ijper.54.3.121 · Published 2020

Purpose: Diabetes mellitus is a global health problem as it is one of the complex disease and main causes of premature illness and death. The present study was focused to scientifically overcome bioavailability drawbacks…

Extraction, Identification and Screening of Brassica oleracea var. italica Plenck (Broccoli) Floret to be an Alternative for Nanoparticle Formulations

Ravindra Chintamani, Kishor Salunkhe, Kiran Kharat, Rudra Pratap Singh, Sonali Diwate

pp. 724–731 · DOI: 10.5530/ijper.54.3.123 · Published 2020

Background: Plant or plant extract act as a source of several abundant natural compounds such as flavonoids, phenolics, alkaloids, steroids, tannins, saponins and other nutritional compounds. The extract not only acts as…

Mimosa pudica Modulates Neuroactive Ligand- Receptor Interaction in Parkinson’s Disease

Taaza Duyu, Pukar Khanal, Nayeem Ashrafali Khatib, Basanagouda Mahadevagouda Patil

pp. 732–739 · DOI: 10.5530/ijper.54.3.124 · Published 2020

Introduction: Mimosa pudica is scientifically reported for the enhancement of memory in multiple animal models including Parkinson’s disease (PD); however, the probable molecular mechanism for this effect has not been ex…

Neuroprotective Effect of Vanda roxburghii Extract in Endothelin-1 (et-1) Induced Hippocampal Ischemic Damage and Ameliorate Cognitive Deficit

Ravi Mundugaru, Sukrant Sharma, Senthilkumar Sivanesan, Rajesh Thangarajan, Pundalik Rama Naik, Nagesh Raju, Ahmed Alfarhan, Rajakrishnan Rajagopal, Bander AlMunqedhi

pp. 740–749 · DOI: 10.5530/ijper.54.3.125 · Published 2020

Introduction: The concept of neuroprotection gaining considerable interest in search for novel therapy that has potential to preserve brain tissues and improve cognitive functions in ischemic brain damage. In the present…

New Naphthyl Substituted Phytosterol and Lanostane Type-triterpenic Esters from the Stem Bark of Ficus religiosa L.

Abuzer Ali, Mohammad Jameel, Mohammed Ali

pp. 750–754 · DOI: 10.5530/ijper.54.3.126 · Published 2020

Background: Ficus religiosa L. (Moraceae) is considered as a holy tree in most of the part of south-eastern Asia. Traditionally, its bark is used in the treatment of burns, diarrhoea, dysentery, gastrohelcosis and gonorr…

Effect of Apricot Fruit and Kernel Extracts on in-vitro Dissolution of Cholesterol Gallstones: Implication for Development of Potent Anti-cholilithiaticc agent

Sunita Waila Tiwari, Archana Negi Sah

pp. 755–760 · DOI: 10.5530/ijper.54.3.127 · Published 2020

Prunus armeniaca L. (apricot) belonging to family Rosaceae is an important edible medicinal plant containing many important constituents like polysaccharides, polyphenol, fatty acid and carotenoids. In this study, we att…

In vivo Anti-diabetic and Anti-hyperlipidemic Activities of ethyl Acetate/Methanol Fractions of Feronia elephantum Fruit in type 2 Diabetic Rats: Via α-amylase and PPAR-γ by using in silico Approach

Gangavaram Jyothi Reddy, Kesavan Bhaskar Reddy, Gopireddy Venkata Subba Reddy

pp. 761–770 · DOI: 10.5530/ijper.54.3.128 · Published 2020

Background: Obesity and overweight, together with physical inactivity, are projected to cause a huge proportion of the global diabetes burden. Natural products play a key role in the discovery of novel therapeutic agents…

Novel Quinolone Substituted Imidazol-5(4H)-ones as Anti-inflammatory, Anticancer Agents: Synthesis, Biological Screening and Molecular Docking Studies

Santosh Kumar, Jignesh C Aghara, Anirudh Manoj, Angel T Alex, Jesil Mathew A, Alex Joesph

pp. 771–780 · DOI: 10.5530/ijper.54.3.129 · Published 2020

Background: Quinolones and imidazolones are important heterocyclic moieties which have been reported to possess potent anti-inflammatory and anticancer properties. The activity of these compounds were related to inhibiti…

Synthesis, Characterization, Biological and Photoluminescence Study of Co(II) Complexes of Fused Heterocyclic Ring Systems

Suyambulingam Jone Kirubavathy, Subramanian Chitra

pp. 781–789 · DOI: 10.5530/ijper.54.3.130 · Published 2020

Aim: To synthesize and characterize the transition metal complexes of fused heteroccylic ring systems. Background: Many of the fused ring heterocyclic compounds were found to be biologically active in the literature like…

Development and Validation of Stability Indicating Method for Estimation of Buparvaquone by Forced Degradation Studies

Shaikh Tanveer Kutubuddin, Shelke Sushil Suresh, Kakde Rajendra Baliram, Lalatsa Aikaterini

pp. 790–797 · DOI: 10.5530/ijper.54.3.131 · Published 2020

Aim: A lucid, rapid and precise stability-indicating method was developed by using HPLC for the estimation of Buparvaquone in bulk as well as pharmaceutical dosage form by forced degradation studies. Materials and Method…

The Significance of Quality Metrics in a Pharmaceutical Quality Management System – A Case Based Study

Narayana Charyulu Rompicherla, Edwin Paul, Akshatha Ganesh, Anoop Narayanan V

pp. 798–808 · DOI: 10.5530/ijper.54.3.132 · Published 2020

Background: The pharmaceutical quality management system is a concept of management function that design and implement the “Quality policy”. The pharmaceutical manufacturing industries all over the world have just begun …

Dynamic Method for Liaison of Community Pharmacists with National Programme for Tuberculosis Control: Efforts to Harness Untapped Opportunities

Rajeswari Ramasamy, Guru Prasad Mohanta, Shobha Rani R Hiremath, Chandramouli Ramnarayanan, Raman Dang, Manjiri S Gharat

pp. 809–818 · DOI: 10.5530/ijper.54.3.133 · Published 2020

Context: Revised National Tuberculosis Control Program (RNTCP) - Directly Observed Treatment-Short course (DOTS) strategy to involve Community Pharmacist (CPs), was conceived and implemented in India, with the objective …

Paediatric Focused Triggering Tool (PFTT) To Assess the Harm and its Utilization to Minimize the Levels of Harm among Children at a Tertiary Care Hospital

Geetanjali Shankarprasad Salimath, Madiwalayya Shivakantayya Ganachari, Manjula Gudhoor

pp. 819–825 · DOI: 10.5530/ijper.54.3.134 · Published 2020

Objectives: Very few paediatric trigger tools have been developed to assess harm in children. Hence, a Paediatric-focused trigger tool has been developed, assess its utility to measure the levels of harm, categorize and …

Fabrication of Poly (Sebacic acid-co-ricinoleic-ester anhydride) with β-cyclodextrin-loaded Doxorubicin Implants and in vitro Characterization

Nagaraja Sreeharsha, Jagadeesh G Hiremath, Bandar E Al-Dhubiab, Girish Meravanige, Ranjith Kumar Karnati, Mahesh Attimarad, Anroop B Nair, Katharigatta N Venugopal, Mohamed A Morsy, Shinu Pottathil, Saleemmulla Khan, Nagashekhara Molugulu

pp. 826–834 · DOI: 10.5530/ijper.54.3.135 · Published 2020

Background: Doxorubicin is an excellent molecule for the formation of biodegradable implants using the poly (sebacic acid-co-ricinoleic-ester anhydride) 70:30 w/w (poly[SARA] 70:30 w/w PSRA 7/3) polymer. Methods: The cyl…