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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Review

Therapeutic Potential of Chymase Inhibitors in Cardiovascular Diseases: An Overview

Qutaiba Ahmed Al Khames Aga1★, Anroop B. Nair2, Wafa Hourani1, Subramani Parasuraman3, Mueen Ahmed KK4, Nagaraja Sreeharsha2★ Corresponding author

  1. 1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Philadelphia University, Amman, JORDAN.
  2. 2Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  3. 3Unit of Pharmacology, Faculty of Pharmacy, AIMST University, Bedong, Kedah, MALAYSIA.
  4. 4Phcog.Net, #17, II Floor, Buddha Vihar Road Cox Town, Bangalore, Karnataka, INDIA.

CORRESPONDENCE

Qutaiba Ahmed Al Khames Aga

Department of Pharmaceutical Sciences, Faculty of Pharmacy, Philadelphia University, Amman, JORDAN.

qutaiba975@gmail.com

Received: 27-05-2020; Revised: 12-06-2020; Accepted: 26-06-2020.

Volume 54, Issue 3 · pp. 509–516 · PUBLISHED 2020 · DOI: 10.5530/ijper.54.3.99

View on IJPER original site ↗

ABSTRACT

Chymase belongs to the family of serine proteases and is mainly warehoused in a heparin proteoglycan macromolecular complex within the mast cells. Extensive studies have been carried out in the last few decades to assess the role of chymase in human diseases. Recent studies have shown the significance of chymase in blood pressure regulation owing to its efficient angiotensin II forming activity. Angiotensin II-generation routes that are associated with human cardiovascular diseases have pathophysiological importance which is still argumentative. Chymase inhibitors play a distinctive role in regulating the renin-angiotensin system as compared to the inhibitors of angiotensin-converting enzyme and type 1 angiotensin II receptor. Therefore, this mechanism may have a role in medical applications of chymase inhibitors by inactivation of the local renin-angiotensin system to avoid cardiovascular diseases. This review highlights the significant role of chymase inhibitors as a potential approach for the management of cardiovascular diseases such as atherosclerosis, hypertension, vascular proliferation, myocardial infarction and heart failure.

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    Aga, Q. A. A. K., Nair, A. B., Hourani, W., Parasuraman, S., KK, M. A., & Sreeharsha, N. (2020). Therapeutic Potential of Chymase Inhibitors in Cardiovascular Diseases: An Overview. Indian Journal of Pharmaceutical Education and Research, 54(3), 509–516. https://doi.org/10.5530/ijper.54.3.99