Volume 54, Issue 3S

2020 · pp. s601–s609 · 37 articles

Volume: 54
Issue: 3S
Published: 2020
Pages: s601–s609
Articles: 37
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Review Article Original Article

In this issue

Review Article

Review
SARS-CoV-2: The Prominent Role of Non-structural Proteins (NSPS) in COVID-19
Uma Sankar Gorla, GSN Koteswara Rao
pp. s381–s389 · DOI: 10.5530/ijper.54.3s.136 · Published 2020
COVID-19, an infectious contagious viral (SARS-CoV-2) disease, associated with morbidity and mortality from respiratory pandemic worldwide. Currently, COVID-19 has no targeted treatment strategies and has been declared b…
Review
Insights on SARS-CoV-2: Emerging Outbreaks of Viral Infections and the Need for Heightening the Antiviral Research
Ramalingam Peraman, Raghuveer Varma Pemmadi, Muthukumaran Peraman, Sathish Kumar Sure
pp. s390–s399 · DOI: 10.5530/ijper.54.3s.137 · Published 2020
Background: Today, about 47 life threatening viruses have been notified for their outbreak potentials including SAR-CoV-2. The proximal origin of SARS-CoV-2 and its affinity to human ACE2 receptors ended in COVID-19 dise…
Review
Attitude, Anxiety, Psychological Effects and Prevention during COVID-19 in India
Debabrata Singh, Shakti Ketan Prusty, Suman Sekhar Sarangi, Surjeet Sahoo, Anil Kumar Biswal
pp. s400–s410 · DOI: 10.5530/ijper.54.3s.138 · Published 2020
With previous health warnings, personal anxieties could feed behavioral changes with many people of India considering notable changes in their transportation use and anticipating in preparation the purchase of goods, par…
Review
3D-printed Drugs: A Fabrication of Pharmaceuticals towards Personalized Medicine
Muhammad Salahuddin Haris, Nur Hakimah Mohd Azlan, Muhammad Taher, Shaiqah Mohd Rus, Bappaditya Chatterjee
pp. s411–s422 · DOI: 10.5530/ijper.54.3s.139 · Published 2020
Background: Three-dimensional (3D) printing fabricates a structure by depositing materials layer-by-layer to form an object. Drug personalization receives attention due to problems arising from drug treatments such as un…
Review
Columns in Pharmaceuticals: For Primers
Sanjay Sharma, Manish Sisodiya, Rupesh Kumar Gautam, Swapnil Goyal
pp. s423–s432 · DOI: 10.5530/ijper.54.3s.140 · Published 2020
Chromatographic processes have a crucial role in the manufacturing of pharmaceuticals, bio-pharmaceuticals, polypeptides, proteins, enzymes and antibodies. They are apprehended, purged and elegant by size exclusion, ion …
Review
A Review on Virtual Classroom
Saba Maanvizhi, Jiyaram Neha Jaiswal, Ravi Ram Narayanan, Rajendra Rohit Jain
pp. s433–s437 · DOI: 10.5530/ijper.54.3s.141 · Published 2020
A virtual classroom is an online learning method that is carried out via internet that provides communication for distance learner just like face-to-face classroom. This field of education is going to be in high trend in…
Review
Using Link and Major System of Memory to Memorise, Remember and Recall Pharmaceutical Sciences Better
Saravanan Jayaram, Santhosh Kumar Ramajayam, Emdormi Rymbai, Deepa Sugumar
pp. s438–s441 · DOI: 10.5530/ijper.54.3s.142 · Published 2020
Traditional memory techniques like mnemonics, flashcards and outline have been used to memorise and recall information as rote learning is not something that can be completely avoided in education. Recently, two memory t…
Review
Novel SARS-CoV-2 and COVID-2019 Outbreak: Current Perspectives on Plant-Based Antiviral Agents and Complementary Therapy
Sevgi Gezici, Nazim Sekeroglu
pp. s442–s456 · DOI: 10.5530/ijper.54.3s.143 · Published 2020
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) caused the novel Corona Virus Disease 2019 (COVID-19), which has been defined as a pandemic by the World Health Organization (WHO) in 2020. The rapid globa…
Review
COVID-19 Vaccine Development, Trials and Tribulations
Juny Sebastian, Mandyam Dhati Ravi, Tegginamat Pramod Kumar
pp. s457–s463 · DOI: 10.5530/ijper.54.3s.144 · Published 2020
The coronavirus disease 19 (COVID-19) is a pandemic viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, COVID-19 has affected 210 countries and territories around the world.…

Original Article

Article
Rational Design and Characterization of Transdermal Patch of Irbesartan for Hypertension
Roshan Kumar Dubey, Hitesh Kumar Dewangan
pp. s464–s472 · DOI: 10.5530/ijper.54.3s.145 · Published 2020
Background: Irbesartan is hypertensive drugs approved for high blood pressure and protect the kidneys damage due to diabetes. It is an angiotensin receptor blockers, belongs to BCS class II, exhibit low and variable oral…
Article
Solid Dosage Forms: A Detailed Research on Non-conforming Product Quality
Katta Hemanth G, Ravindra Shenoy U, Girish Thunga, Sudeep Kumar Agrawal, Mahendra Joshi, Muddukrishna Badamane Sathyanarayana, Vamshi Krishna Tippavajhala, Abhinaya N, Girish Pai Kulyadi
pp. s473–s484 · DOI: 10.5530/ijper.54.3s.146 · Published 2020
Introduction: Any defects in pharmaceutical products lead to minor, major, or critical deviation and if such a product is released, it also leads to product recalls and legal actions. In such cases, the concern is about …
Article
Effect of Plasticizer on Delivery of Valsartan from Tamarind Gel Based Transdermal Film Formulation
Braja Bihari Panda, Ayan Chatterjee, Rudra Narayan Sahoo, Subrata Mallick
pp. s485–s491 · DOI: 10.5530/ijper.54.3s.147 · Published 2020
Purpose: The present investigation was undertaken to study the effect of different plasticizers on the drug delivery pattern of valsartan from tamarind gum based hydroxypropyl methylcellulose (HPMC K100) transdermal film…
Article
Effective Single Drug Treatment of Lymphatic Filariasis through Enhanced Transdermal Delivery of Ivermectin Liposomes using Solid and Dissolving Microneedles
Jyothirmayee Devineni, Ch.Durga Pravallika, Boothapati Sudha Rani, Buchi Naidu Nalluri
pp. s492–s504 · DOI: 10.5530/ijper.54.3s.148 · Published 2020
Objectives: The present investigation was to study the combination of liposomes (LP) and microneedles (MNs) as a single drug treatment approach for the delivery of an antifilarial drug, ivermectin (IVM) in which the role…
Article
Development and Characterization of Mucoadhesive Buccal Gel Containing Lipid Nanoparticles of Triamcinolone Acetonide
Dandagi Panchaxari Mallappa, Fernandes Reesha Chelsea, Raikar Prasiddhi Ratnakar, Gadad Anand Panchakshari, Mastiholimath Vinayak Shivamurthi, Bhat Samritha Uppinangady
pp. s505–s511 · DOI: 10.5530/ijper.54.3s.149 · Published 2020
Background: Triamcinolone Acetonide is a synthetic glucocorticosteroid which has been used for its immunosuppressive and anti-inflammatory activity belonging to BCS class IV, yet it is not recommended to be used at highe…
Article
Fabrication of Triprolidine∙HCl Transdermal Drug Delivery System and Pharmacokinetic Studies
Afzal Haq Asif, Niranjan Puttaswamy Hodalur, Nagaraja Sreeharsha, Jagadeesh Gurupadayya Hiremath, Keyur Shileshbhai Mistry, Bandar E Al-Dhubiab, Girish Meravanige, Ranjith Kumar Karnati, Saleemulla Khan, Muhammed Mubin, Aiswarya Thelakkadan Chathoth
pp. s512–s520 · DOI: 10.5530/ijper.54.3s.150 · Published 2020
The purpose was to examine and analyze the matrix system of Triprolidine∙HCl wth the selected polymer ethyl cellulose. We achieved in vitro permeation studies using Keshary Chien diffusion cells across guinea pig skin. C…
Article
Effect of Atorvastatin on 7,12-Dimethylbenz (α) Anthracene and Testosterone-induced Prostatic Intraepithelial Neoplasia in the Prostate of Wistar Rats: Role of TRPM7
JianhengChen JianhengChen, ZhengchaoShen ZhengchaoShen, PengGu PengGu, XiaodongLiu XiaodongLiu, JihongShen JihongShen, BhavinVyas BhavinVyas, KunbinKe KunbinKe
pp. s521–s528 · DOI: 10.5530/ijper.54.3s.151 · Published 2020
Aim/Background: The current study was conducted to examine the influence of atorvastatin in experimentally induced prostatic intraepithelial neoplasia in rats. TRPM7 is a potential therapeutic target for treatment of pro…
Article
Ellagic Acid Protects against Activation of Microglia by Inhibiting MAPKs and NF-κB Signalling
Elysha Nur Ismail, Norazrina Azmi, Ibrahim Jantan
pp. s529–s536 · DOI: 10.5530/ijper.54.3s.152 · Published 2020
Context: One of the hallmarks of neurodegenerative diseases is dysregulation of microglia resulting in neuroinflammation. Neuroinflammation is related to multiple neurodegenerative disorders, including stroke and Alzheim…
Article
Arecoline, Hesperidin and Trifluoperazine-mediated Cytotoxicity and Cell Death Potential in NIH/3T3 Fibroblasts Cells –Toxicity/Safety Assessment in a NIH/3T3 Model Fibroblast Cell Line
Vembuli A Varadharaj, Suresh PK
pp. s537–s551 · DOI: 10.5530/ijper.54.3s.153 · Published 2020
Aim/Background: Arecoline is considered to be the principal etiologic agent for Oral Sub mucous Fibrosis (OSF) with the buccal fibroblasts being the major target. Hence, this model alkaloid has been used to evaluate toxi…
Article
In-silico Strategies of Some Selected Phytoconstituents from Zingiber officinale as SARS CoV-2 Main Protease (COVID-19) Inhibitors
DSNBK Prasanth, Siva Prasad Panda, Atmakuri Lakshmana Rao, Guntupalli Chakravarti, Nayudu Teja, Veenam Bhavya Naga Vani, Tera Sandhya
pp. s552–s561 · DOI: 10.5530/ijper.54.3s.154 · Published 2020
Background: Zingiber officinale (Zingiberaceae) has been utilized to remedy many afflictions of humans. Literary works illustrate that it possesses numerous biological activities. Methods: Today, research study intended …
Article
Protective Effect of Rhizophora mucronata Leaves on Hepatic Oxidative Stress, Serum Cytokines and Insulin Resistance in Type 2 Diabetic Rats
Moumita Ray, Rania Indu, Sangita Bhattacharya, Anjan Adhikari
pp. s562–s569 · DOI: 10.5530/ijper.54.3s.155 · Published 2020
Aim: Glucose homeostasis is mainly controlled by liver, which is altered in diabetes. Metabolic alteration and insulin resistance develop due to oxidative stress and inflammation. Plant secondary metabolites have therape…
Article
In vitro Antioxidant Potential and Cytotoxicity Study of Asparagus aethiopicus L. Extracts on HT-29 Human Colon Cancer Cell Line
Suhas Suresh Awati, Ritu M Gilhotra, Santosh K Singh, Vinit Raj, Kiran A Wadkar
pp. s570–s579 · DOI: 10.5530/ijper.54.3s.156 · Published 2020
Objectives: To decide the phytochemical constituents, antioxidant and anticancer potential of Asparagus aethiopicus L. extracts on HT-29 human colon malignant growth cell line. Methods: The roots of plant were exposed to…
Article
Clot Lysis Capacity of Andrographis paniculata and its Pure Compound Andrographolide
Muhammad Torequl Islam
pp. s580–s585 · DOI: 10.5530/ijper.54.3s.157 · Published 2020
Background: Andrographis paniculata and its main components andrographolide (AGL) have been reported for their promising cardio-protective effects in experimental animals. Aim: To investigate clot lysis activity of A. pa…
Article
S586 Indian Journal of Pharmaceutical Education and Research |Vol 54 | Issue 3 [Suppl] | Jul-Sep, 2020 Original Article www.ijper.org HPTLC Densitometric Quantification of Kaempferol from Leaves of Euphorbia neriifolia
Prashant Y. Mali, Swapnil Goyal
pp. s586–s592 · DOI: 10.5530/ijper.54.3s.158 · Published 2020
Objectives: To study HPTLC densitometric quantification of kaempferol in aqueous extract fraction (EN6) of leaves of Euphorbia neriifolia Linn. Methods: Chromatographic method was employed on pre-washed and pre-activated…
Article
Phytoformulation of Tagetes patula for Improving Permeability and Prevention of Hyperlipidaemia
Sneha Nawale, Sujit Das, Priyanka N, Ganga Raju M
pp. s593–s600 · DOI: 10.5530/ijper.54.3s.159 · Published 2020
The present study was aimed to formulate phytoformulation of Tagetes patula (MSTP) and its evaluation for antihyperlipidemic activity with triton X-100 and propyl thiouracil induced hyperlipidaemia models. Microsuspensio…
Article
Anti-diarrheal Activity of Caffeine: A Modulatory Effect with Loperamide and through 6FH5 (PIK3CG) Protein Interaction Pathway
Farhana Faria, Shardar Mohammad Hafiz Hassan, Rajib Hossain, Mahmuda Akter Mukta, Md. Ashiqur Rahman Chowdhury, Muhammad Torequl Islam
pp. s601–s609 · DOI: 10.5530/ijper.54.3s.160 · Published 2020
Background: Caffeine (CAF) is known for its central nervous system stimulatory effect. Although, CAF use in diarrhea, especially in Runner's diarrhea is still controversial, but it has been reported that dark tea contain…
Article
Synthesis and QSAR Studies of Novel Pyrazoline Derivatives as Antiproliferative Agent
Prafulla Madhukarrao Sable, Nusrat Bhuru Ali Sayyad
pp. s610–s619 · DOI: 10.5530/ijper.54.3s.161 · Published 2020
Background: Regardless of recent advances in the biological processes leading to the development of cancer, there is still a need for new and effective agents to help bring this disease under control. The revelation of t…
Article
In silico Docking and 3D-QSAR Studies of Novel N’-substituted-(pyrrolyl-phenoxy) Acetohydrazides as Enoyl-ACP Reductase Antagonists
Shrinivas Dattatraya Joshi, SR Prem Kumar, Venkatarao H Kulkarni, Ali Mohamed Alshabi, Ibrahim Ahmed Shaikh, TM Aminabhavi
pp. s620–s632 · DOI: 10.5530/ijper.54.3s.162 · Published 2020
In search of potent anti-mycobacterial agents, enoyl-ACP reductase enzyme found to be most probable due to its imperative role in type II fatty acid synthesis (FAS), while mycolic acid production in Mycobacterium tubercu…
Article
Synthesis and Characterization of Some Novel N-Phenylpyrazole Analogues for the Evaluation of their Potentials as Anticancer, Antimicrobial and Antioxidant Agents
Vijai Varma Pothuri, Venkata Satya Machiraju Palagummi, Samba Siva Rao Vasa
pp. s633–s643 · DOI: 10.5530/ijper.54.3s.163 · Published 2020
Objectives: With a view to invent new anticancer agents, the authors proposed to prepare a series of N-phenylpyrazole derivatives by introducing biologically active pharmacophores viz., Fluoro/Fluoromehtyl benzamide and …
Article
A Novel Validated Stability Indicating Analytical Method for Simultaneous Quantification of Metformin Hydrochloride and Empagliflozin in Bulk and Marketed Formulation by HPTLC using Box-Wilson Experimental Design Approach
Manojkumar K. Munde, Nilesh S. Kulkarni, Ashim K. Sen, Dhanya B. Sen
pp. s644–s656 · DOI: 10.5530/ijper.54.3s.164 · Published 2020
Background: A novel stability indicating analytical method was developed and validated by High Performance Thin Layer Chromatography (HPTLC) using Design of experiment approach. The proposed method is useful for quantifi…
Article
Application of Design of Experiment Based Innovative Approach in Method Development and Validation of RP-HPLC for Estimation of Azilsartan in Bulk and Pharmaceutical Tablet Dosage Form
Siddhata Arjun Deshmukh, Suvarna Sharad Vanjari, Rajendra Bhagwan Patil, Kishanchandra Radheshyam Khandelwal
pp. s657–s666 · DOI: 10.5530/ijper.54.3s.165 · Published 2020
Aim: Azilsartan is an angiotensin II receptor blocker used in the treatment of hypertension. Using the DoE based approach in reversed-phase high-performance chromatography method was developed and validated as per ICH gu…
Article
Novel Validated UV Spectroscopic Method for Routine Analysis of Decitabine Drug Substance
Ankit Awasthi, Dheeraj HM, Muddukrishna Badamane Sathyanarayana
pp. s667–s670 · DOI: 10.5530/ijper.54.3s.166 · Published 2020
Objectives: In the proposed study, a basic, novel, protected economic, delicate and cost-effective UV-Spectrophotometric technique for the analysis of Decitabine which is antineoplastic drug. Methods: The created method …
Article
Method Development and Validation of Ephedrine and Pseudoephedrine in Horse Urine by Liquid Chromatography-Tandem Mass Spectrometry
Ashok Kumar Maurya, Puran Lal Sahu, Sakshi Jethi, Himank Gosain, Kapendra Sahu
pp. s671–s676 · DOI: 10.5530/ijper.54.3s.167 · Published 2020
Background: A comprehensive, fast and precise method for the quantification of ephedrine and pseudoephedrine in horse urine was established and validated utilizing Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS…
Article
A Validated Stability-indicating RP-HPLC Method for Piperine Estimation in Black Pepper, Marketed Formulation and Nanoparticles
Bhaskar Kurangi, Sunil Jalalpure
pp. s677–s686 · DOI: 10.5530/ijper.54.3s.168 · Published 2020
Aim: The aim of the study was to develop and validate a simple stability indicating reversephase High Performance Liquid Chromatography (RP-HPLC) method for quantitative analysis of piperine in Ayurvedic marketed formula…
Article
Simultaneous Quantification of Quercetin and Syringic Acid in Methanolic Extract of Leucas lavandulifolia by using Validated HPTLCDensitometric Method
Pushpendra Kumar Shukla, Akanksha Srivastava, Ankita Misra, Sharad Srivastava
pp. s687–s694 · DOI: 10.5530/ijper.54.3s.169 · Published 2020
A simple, sensitive and reliable High Performance Thin Layer Chromatography (HPTLC) method was developed for the simultaneous quantification of bioactive compounds i.e quercetin and syringic acid in Leucas lavandulifolia…
Article
Impact of Verbal and Web-based Patient Education Programs Driven by Clinical Pharmacist on the Adherence and Illness Perception of Hypertensive Patients
ZekiyeYılmaz ZekiyeYılmaz, MesutSancar MesutSancar, BetülOkuyan BetülOkuyan, OsmanYeşildağ OsmanYeşildağ, FikretVehbiİzzettin FikretVehbiİzzettin
pp. s695–s704 · DOI: 10.5530/ijper.54.3s.170 · Published 2020
Background: Patient education is a substantial factor for the management of inveterate diseases. The aim of this study is to assess the impact of patient education given by clinical pharmacist using different (verbal and…
Article
Machine Learning-Based Decision Support System for Early Detection of Breast Cancer
Mochen Li, Gaurav Nanda, Santosh Chhajedss, Raji Sundararajan
pp. s705–s715 · DOI: 10.5530/ijper.54.3s.171 · Published 2020
Background: Breast cancer is one of the leading causes of death of women in the United States and also one of the most malignant cancer among women worldwide. Early, more accurate detection of breast cancer enables exten…
Article
Assessment of Knowledge of Diabetic Patients about Glycemic Abnormalities and Medicine Storage in Makkah during Hajj Pilgrimage
Kolthoom Othman, Aejaz Abdul Latif Khan, Syed Mohammad Shakeel Iqubal, Tasneem Mohammed, Muazzam Sheriff Maqbul, Mohammed Gamal, Mohammad Mahmoud Al-Sanea, Mohammed Elmowafy, Khaled Shalaby, Dibya Sundar Panda, Saleh Alghamdi
pp. s716–s721 · DOI: 10.5530/ijper.54.3s.172 · Published 2020
Objectives: The main objective of this research was to evaluate the awareness about symptoms of diabetes and dealing with those symptoms, management and storage of drug especially for the heat sensitive hormone (insulin)…