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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

In-silico Strategies of Some Selected Phytoconstituents from Zingiber officinale as SARS CoV-2 Main Protease (COVID-19) Inhibitors

DSNBK Prasanth1, Siva Prasad Panda1,2, Atmakuri Lakshmana Rao3, Guntupalli Chakravarti1, Nayudu Teja4, Veenam Bhavya Naga Vani3, Tera Sandhya5

  1. 1Pharmacognosy Research Division, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, INDIA.
  2. 2Pharmacology Research Division, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, INDIA.
  3. 3Department of Pharmaceutical Analysis, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, INDIA.
  4. 4Department of Pharmaceutics, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, INDIA.
  5. 5Department of Pharmacology, Institute of Pharmaceutical technology, Sri Padmavati Manila Visvavidyalayam, Tirupati, Andhra Pradesh, INDIA.

CORRESPONDENCE

dsnbkprasanth@kluniversity.in

Received: 13-05-2020; Revised: 07-07-2020; Accepted: 13-08-2020.

Volume 54, Issue 3S · pp. s552–s561 · PUBLISHED 2020 · DOI: 10.5530/ijper.54.3s.154

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ABSTRACT

Background: Zingiber officinale (Zingiberaceae) has been utilized to remedy many afflictions of humans. Literary works illustrate that it possesses numerous biological activities. Methods: Today, research study intended to recognize the Phyto-derived antiviral substances from Zingiber officinale against COVID-19 main protease enzyme and to understand the molecular basis of its activity. Methods: In the present study, 42 molecules obtained from Z. officinale, which are retrieved from the Pubmed database, are studied via docking study. Docking study was performed using Autodock vina and PyRx software. Afterwards, admet SAR, as well as Dru Li to servers, were made use of for drug-likeness prophecy. Results: Our study shows that the nine phytochemicals of Z. officinale are very likely against the main protease enzyme of COVID-19. Utilizing contemporary strategies, these phyto-compounds might use to establish a reliable medication from a natural origin. Conclusion: The substances identified potential as possible anti-virals. However, even more, in-vitro studies are needed to examine their effectiveness versus COVID-19.

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    Prasanth, D., Panda, S. P., Rao, A. L., Chakravarti, G., Teja, N., Vani, V. B. N., & Sandhya, T. (2020). In-silico Strategies of Some Selected Phytoconstituents from Zingiber officinale as SARS CoV-2 Main Protease (COVID-19) Inhibitors. Indian Journal of Pharmaceutical Education and Research, 54(3S), s552–s561. https://doi.org/10.5530/ijper.54.3s.154