Volume 54, Issue 4

2020 · pp. 835–1206 · 44 articles

Volume: 54
Issue: 4
Published: 2020
Pages: 835–1206
Articles: 44
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Review Article Original Article

In this issue

Review Article

Review
Reduced Pharma Supply Chain in COVID-19: Measures to Reduce India’s Reliance for Active Pharmaceutical Ingredients on China and other Countries
Narendra Vyas, Ankur Joshi, Sapna Malviya, Anil Kharia
pp. 835–842 · DOI: 10.5530/ijper.54.4.175 · Published 2020
India, which is called the “world of pharmacy” for being a top supplier of medicines in several countries, can depend on other countries for Active Pharmaceutical Ingredients (API) and other raw materials. Although India…
Review
Artificial Intelligence: A New Paradigm for Pharmaceutical Applications in Formulations Development
Nagalakshmi Sethuraman
pp. 843–846 · DOI: 10.5530/ijper.54.4.176 · Published 2020
Artificial Intelligence is a branch of engineering that specializes in developing intelligent machines. The utilization of artificial intelligence in pharmaceutical technology has elevated over the years. Over the beyond…
Review
An Outbreak of Severe Acute Respiratory Syndrome-2019 (COVID-19): A Major Health Concern
Mohd Sajad, Mofieed Ahmed, Sonu Chand Thakur
pp. 847–857 · DOI: 10.5530/ijper.54.4.177 · Published 2020
In Wuhan City, the province of Hubei, China, there appeared an unusual epidemic of pneumonia of uncertain ethology in December 2019. A novel coronavirus was identified by the World Health Organisation (WHO) as the trigge…
Review
Pharmaceutical and Biotechnological Importance of Actinobacterial Products
Krishnamoorthy Bhakyashree, Krishnan Kannabiran
pp. 858–864 · DOI: 10.5530/ijper.54.4.178 · Published 2020
Many compounds produced by marine microbes possess significant pharmaceutical applications. Actinobacteria are one among the microbes producing a variety of antibiotics. Apart from antibiotics, it also produces many nove…
Review
Using Chloroquine and Hydroxychloroquine in the Treatment of COVID-19: Does It Make Sense?
Ronan Batista
pp. 865–874 · DOI: 10.5530/ijper.54.4.179 · Published 2020
The severe acute respiratory syndrome caused by the new coronavirus SARS-Cov-2 (COVID-19) has quickly turned into a pandemic, infecting more than 10 million people and causing more than 500,000 deaths worldwide. The abse…

Original Article

Article
The Need for Simulated Patient Method Implementation in Pharmaceutical Education in Poland
Magdalena Cerbin-Koczorowska, Piotr Przymuszała, Magdalena Waszyk- Nowaczyk, Beata Plewka, Ryszard Marciniak
pp. 875–880 · DOI: 10.5530/ijper.54.4.180 · Published 2020
Background: Changing societal expectations towards pharmacy graduates and increased focus on communication skills, interprofessional collaboration and pharmaceutical care in their curricula, point out necessity of using …
Article
Training in Professional Pharmacy Services through Educational Videos
Zarzuelo Maria Jose, Valverde-Merino Maria-Isabel, Fernandez-Rodriguez Maria, Amador-Fernandez Noelia, Martinez-Martinez Fernando
pp. 881–887 · DOI: 10.5530/ijper.54.4.181 · Published 2020
Objectives: Pharmaceutical Care is a subject within the Pharmacy degree that can not only be taught using theoretical frameworks but also requires new teaching tools, like a simulated educational video. The objective of …
Article
Drug Development Chain and Professional Curriculum Chain Integrated Pharmacy Courses
Haibo Yan, Haibo Zhou, Sha Li, Kaihe Ye, Yunlu Jiang, Pinghua Sun
pp. 888–895 · DOI: 10.5530/ijper.54.4.182 · Published 2020
Background: The disjointed problem of pharmacy education training and research in the pharmaceutical industry has become increasingly prominent, restricting the "professional idea or competency transfusion" ability from …
Article
An Approach to the Evaluation of Program Outcomes and Consideration of Activities beyond Curriculum for Improvement of Program Outcome Attainment
Tauro Savita J, Dhokchawle Bharat V, Barchha Avinash B, Jain Meeta N
pp. 896–904 · DOI: 10.5530/ijper.54.4.183 · Published 2020
Current global scenario demands outcome based education to develop graduates with universal acceptability. Program Outcomes (POs) laid by NBA (Table 1) are the assessable components indicative of graduate potential to de…
Article
Implementation of an Innovative Learning Resource with Project to Facilitate Active Learning to Improve Students’ Performance on Chemistry
Manihar Situmorang, Jamalum Purba, Ramlan Silaban
pp. 905–914 · DOI: 10.5530/ijper.54.4.184 · Published 2020
Background: The provision of suitable and comprehensive learning resources concedes to be an effective strategy to create a serviceable learning process to achieve the competencies needed by students. Objectives: This re…
Article
Promoting Student-Run Online Class Review Activities as Effective Cooperative Learning
Kanong Ruttanokorn, Paiboon Nuntanakorn, Sarayut Janmahasatian, Theerasak Rojanarata
pp. 915–920 · DOI: 10.5530/ijper.54.4.185 · Published 2020
Objectives: The aim of this work was to enable students to set up and organize for themselves online review activities after class. Materials and Methods: Students worked as groups to create short notes and quizzes that …
Article
In-situ Gelling System for Mucoadhesive Site- Specific Drug Delivery for Treatment of Recurrent Vaginal Candidiasis
Gurpreet Singh, Shilpa Shilpa, Waseem Ali, Amita Sarwal
pp. 921–934 · DOI: 10.5530/ijper.54.4.186 · Published 2020
Objectives: The purpose of this work was to design and evaluate bio adhesive films for effective treatment against vaginal candidiasis. Fluconazole, a bis tri-azole agent inhibits ergosterol synthesis leading to the disr…
Article
Development of Donepezil Hydrochloride Loaded Gellan Gum Based Nasal Mucoadhesive Microspheres by Spray Drying Method
Purushottam Gangane, Pravin Kawtikwar
pp. 935–945 · DOI: 10.5530/ijper.54.4.187 · Published 2020
Objectives: The aim of present study was the formulation of donepezil hydrochloride loaded polymeric mucoadhesive microspheres for delivery via nasal route to increase the residence time and absorption of drug from the n…
Article
Preparation of Ketoconazole Liposomes with an Ultrasonic and an Injection Method Using Vegetable Oils
Olga Popovska, Jana Simonovska, Zoran Kavrakovski, Vesna Rafajlovska
pp. 946–953 · DOI: 10.5530/ijper.54.4.188 · Published 2020
Introduction: Ketoconazole as antimycotic drug have a great impact in the treatment of many skin diseases. The toxicity of available ketoconazole in form of tablets, cream and shampoo is overcome by encapsulation in lipo…
Article
Development and Evaluation of Flurbiprofen Loaded Transethosomes to Improve Transdermal Delivery
Anand Panchaxari Gadad, Archana Sidagouda Patil, Yashica Singh, Panchaxari Mallappa Dandagi, Uday Baburao Bolmal, Ananya Basu
pp. 954–962 · DOI: 10.5530/ijper.54.4.189 · Published 2020
Background: Flurbiprofen is prescribed for the symptomatic management of arthritis. Its oral administration leads to gastrointestinal damage and it has a short elimination halflife requiring multiple dosing. Transdermal …
Article
Mucoadhesive in-situ Gel Formulation for Vaginal Delivery of Tenofovir Disoproxil Fumarate
Anita Prahladbhai Patel, Jayvadan K. Patel
pp. 963–970 · DOI: 10.5530/ijper.54.4.190 · Published 2020
Introduction: Tenofovir disoproxil fumarate is an anti-retroviral medicine which belongs to microbicides class being formulated for a woman instigated technique of prevention of the human immunodeficiency virus infection…
Article
Formulation and Evaluation of Phanera variegata Linn. Mucilage as a Pharmaceutical Binder in Solid Dosage Form
Keshav Bansal, Meenakshi Bajpai
pp. 971–982 · DOI: 10.5530/ijper.54.4.191 · Published 2020
Objectives: The present study is aimed to isolate, evaluate the mucilage obtained from the leaves of Kachnar (Phanera variegata) and to compare the binding efficacy of the isolated mucilage with acacia gum. Methods: Extr…
Article
Preparation and Characterization of Directly Compressible Spherical Agglomerates of Etoricoxib
Hagalavadi Nanjappa Shivakumar, Vanita Somasekhar, Anwesha Roy
pp. 983–990 · DOI: 10.5530/ijper.54.4.192 · Published 2020
Aim: The current work contemplates formulation of spherical agglomerates of Etoricoxib, with a view to improve the flow properties, solubility and dissolution rate. Materials and Methods: Spherical agglomerates of etoric…
Article
Investigation of Effect of Phytoconstituents Aloe Emodin and Quercetin on Bioavailability of Albendazole
Harsh Verma, Ravindra Kumar Pandey, Shiv Shankar Shukla, Bina Gidwani, Amber Vyas
pp. 991–998 · DOI: 10.5530/ijper.54.4.193 · Published 2020
Background/Aim: Albendazole is a drug with benzimidazole nucleus and is poorly absorbed from the gastrointestinal tract due to its low aqueous solubility. The objective of present work was to study the effect of two phyt…
Article
Insulin Resistance Modulation with Lifestyle Modification- Proof-of-Concept Study in Rats
Afzal Haq Asif, Prem Kumar Nanjundan, Girish Meravanige Basavarajappa, Nagaraja Sreeharsha, Uma Chandur, Teeka Srinivasasetty Roopashree
pp. 999–1006 · DOI: 10.5530/ijper.54.4.173 · Published 2020
Purpose: Fatigue, a physical and/or mental exhaustion is a common symptom of diabetes. Easy fatigability is not limited to uncontrolled diabetes however is comorbid with psychological, medical, metabolic, and chronic com…
Article
Development of Solid Dispersions of Clopidogrel using Innate Excipient: Synergistic Antiplatelet Activity
Chander Pal Singh Verma, Santosh Verma, Mahendra Singh Ashawat, Vinay Pandit
pp. 1007–1015 · DOI: 10.5530/ijper.54.4.194 · Published 2020
Aim: The present study encompasses on formulation and evaluation of solid dispersion of Clopidogrel, Class II drug-using pectin extracted from mango peel. Materials and Methods: Pectin was extracted from full-grown mango…
Article
Evaluation of Gelling Behavior of Natural Gums and their Formulation Prospects
Rachit Mohan, Shobha Singh, Geetendra Kumar, Manjoosha Srivastava
pp. 1016–1023 · DOI: 10.5530/ijper.54.4.195 · Published 2020
Purpose: Gums and polymers can be found abundantly in the nature from various plants, microbial and marine sources. Their physical and functional characteristics can be customized according to its application in product …
Article
Influence of Ketogenic Diet and Phenytoin Sodium on Isoniazid Induced Epilepsy in Wistar Rats
Somasundaram Ramachandran, Satya Sravanthi, Sri Ramya Manthena, Undru Liza, Masa Amala
pp. 1024–1030 · DOI: 10.5530/ijper.54.4.196 · Published 2020
Aim: The current research was set up to estimate the influence of ketogenic diet in combination with phenytoin sodium on isoniazid induced epilepsy in rats. Methods: In this work 30 rats were used with weight range of 15…
Article
In silico Evaluation on the Inhibition Efficacy of Five Antivirals on SARS-CoV-2 Protease (COVID-19)
Vinod Palayoor Raphael, Shaju Kanimangalath Shanmughan
pp. 1031–1038 · DOI: 10.5530/ijper.54.4.197 · Published 2020
Background: All over the world rigorous research attempts are going on to find a remedy for the spreading and prevention of the dreadful pandemic of 21st century, the Coronavirus Disease (COVID-19). To discover an effect…
Article
Asarone and Metformin Modulates the Oxidant- Antioxidant Imbalance on Experimentally Induced Hepatocellular Carcinoma during Diabetic Condition
Bhrigu Kumar Das, Pramod Channabasappa Gadad
pp. 1039–1045 · DOI: 10.5530/ijper.54.4.198 · Published 2020
Aim: The aim of the present study was planned to investigate the efficacy of asarone and metformin HCl as an antioxidant on experimentally induced diabetic-hepatocellular carcinoma (HCC) condition in male Wistar rats. Me…
Article
Effect of Normosil Probiotic Supplementation on the Growth Performance and Blood Parameters of Broiler Chickens
Airat Khabirov, Fail Khaziakhmetov, Vyacheslav Kuznetsov, Hamit Tagirov, Maksim Rebezov, Aleksandra Andreyeva, Almaz Basharov, Zhanibek Yessimbekov, Muhammad Ayaz
pp. 1046–1055 · DOI: 10.5530/ijper.54.4.199 · Published 2020
Purpose: This study was aimed to investigate the effects of probiotic “Normosil” containing a mixture of living cultures of Lactobacillus and Enterococcus strains at a concentration of 1×106 and 1×107 CFU/mL was assessed…
Article
Antiangiogenic Potential of Levetiracetam by Blocking N-type Voltage Gated Calcium Channels
Chandana Kamili, Hima Sowmya Kandoti, Sunil Kumar Sarolu, Suresh Merugu, Abbulu Konde
pp. 1056–1061 · DOI: 10.5530/ijper.54.4.200 · Published 2020
Objectives: Angiogenesis is generation of micro vessels. These ion channels on endothelium play vital functions in cell proliferation, migration, cell volume expansion and in related angiogenesis. Our study aims to evalu…
Article
Xanthine Oxidase and Lipid Peroxidation Inhibition of Taiwan Folkloric Medicine Factors Affecting Rhus semialata var. Roxburghiana Activities against Xanthine Oxidase and Ferrous Iron-induced Lipid Peroxidation on Mice Liver Mitochondria
Po-Wei Tsai, Pei-Chin Lin, Ling-Ling Yang, Ai-Ho Liao, Bo-Cheng Wang, Ming-Shun Wu
pp. 1062–1071 · DOI: 10.5530/ijper.54.4.201 · Published 2020
Background: Gout, a disease characterized by recurrent inflammatory for urate deposit from overactive xanthine oxidase, is common among Taiwanese. Rhus semialata var. roxburghiana (RSR) grows wildly in Central Mountain o…
Article
Standardization of Trigonella foenum-graecum L. Seeds: A Quality by Design Approach
Vishakha Parab Gaonkar, Kirankumar Hullatti, Vinodh Mannur
pp. 1072–1079 · DOI: 10.5530/ijper.54.4.202 · Published 2020
Aim: To standardize Trigonella foenum-graecum L. Seeds by developing QbD based HPLC method for identification and quantification of trigonelline in T. foenum graecum L. seeds, along with evaluation of various quality con…
Article
Evaluation of Hepatoprotective Effect of a Polyherbal Megakutki against Paracetamol-Induced Hepatotoxicity
Asha Elizabeth Giri, Vanishree Rao, Sandeep Singhal, Karthik Gourishetti, Subhankar Biswas, Krishnadas Nandakumar, Mallikarjuna Rao Chamllamudi, Jeetesh Dave, Rakesh Dave, Suhani Sumalatha, Nitesh Kumar
pp. 1080–1088 · DOI: 10.5530/ijper.54.4.203 · Published 2020
Background: Megakutki® (MK) is a polyherbal preparation of 11 standardized extracts that are individually proven for hepatoprotection scientifically. Aim: Study evaluated MK’s hepatoprotective potential against paracetam…
Article
Neuroprotective effect of 1, 3-β-glucan-curcumin mixing (Bioglucur) on Alzheimer Disease Induced in Mice by Aluminium Toxicity
Nesrine Ouda Amari, Noureddine Djebli, Le Mai Huong, Tran Thi Hong Ha, Nguyen Dinh Luyen, Vu Thi Bich
pp. 1089–1097 · DOI: 10.5530/ijper.54.4.204 · Published 2020
Aim: The aim of this study was to evaluate the neuroprotective effect of oral administration of acomplex of curcumin with 1,3-β-glucan extracted from Vietnamese mushrooms named Bioglucur to increase drug delivery efficie…
Article
HPTLC Fingerprinting: A Tool for Simplified Analysis of Phenolics in Medicinal Plants
Amit Yadaorao Saraf, Aparna Amit Saraf
pp. 1098–1103 · DOI: 10.5530/ijper.54.4.205 · Published 2020
Background: Phenolic compounds especially the flavonoids and tannins comprise one of the most significant classes of plant secondary metabolites. Aim: HPTLC is widely accepted by WHO and pharmacopoeia across the globe as…
Article
Phytochemical Investigation, TLC-HPLC Fingerprinting and Antioxidant Activity of Cissus repanda Roots
SachinBhusari SachinBhusari, KanchanNikam KanchanNikam, BhanudasKuchekar BhanudasKuchekar, PravinWakte PravinWakte
pp. 1104–1108 · DOI: 10.5530/ijper.54.4.206 · Published 2020
Aim: To perform phytochemical screening, TLC, HPLC fingerprinting and antioxidant assay of Aqueous, Aqueous-Ethanolic and 95% Ethanolic extracts of Cissus repanda roots. Methods: Aqueous, Aqueous-Ethanolic and 95% Ethano…
Article
Antioxidant and Anti-inflammatory Activity Screening of Lasia spinosa Rhizome and its Validation using a Computational Simulation Approach
Arya Lakshmi Marisetti, Mohan Gandhi Bonthu, Ganga Rao Battu
pp. 1109–1120 · DOI: 10.5530/ijper.54.4.207 · Published 2020
Background: The present work assesses the antioxidant and anti-inflammatory effect of Lasia spinosa rhizome extracts on in-vitro and in-vivo models compiled through molecular docking study of plant-steemed phytocompounds…
Article
Synthesis, in-silico Studies and Evaluation of Anticancer Activity of Some Novel Benzothiazole Substituted 4-Thiazolidinones
Chaithra Raju Shetty, Katte Ishwar Bhat, Abhishek Kumar, Pankaj Kumar, Praveen Thaggikuppe Krishnamurthy, Vijay Kumar Merugumolu
pp. 1121–1132 · DOI: 10.5530/ijper.54.4.208 · Published 2020
Background: Cancer is one of the leading diseases associated with the high degree of mortality. In current scenario chemotherapy is the major treatment for cancer and it still has few limitations. The continuous seek for…
Article
An in-depth Study of the Concept of Chirality in Organic and Pharmaceutical Chemistry: Using Crystal Structure Data with 3D Visualization Software
Yi Yang, Jian Xu, Gao Cao
pp. 1133–1143 · DOI: 10.5530/ijper.54.4.209 · Published 2020
Background: Chirality is an essential feature of life and a universal phenomenon in nature, chirality in chemistry and biochemistry is closely related to biological, spectroscopic and physical properties. The concept of …
Article
Novel Stability Indicating RP-HPLC Method Development and Validation for Simultaneous Estimation of Alfuzosin and Dutasteride in Pharmaceutical Dosage Form
Keerthana Diyya
pp. 1144–1152 · DOI: 10.5530/ijper.54.4.210 · Published 2020
Aim: The present study was to develop a simple, accurate and stable reverse phase liquid chromatographic method and validate in bulk drug and pharmaceutical dosage form for the simultaneous determination of Alfuzosin Hyd…
Article
New Method for the in vivo Estimation of Fluvastatin and its Application for Pharmacokinetic Studies in Rabbit
Deepthi Sandhala, Srinivas Lankalapalli
pp. 1153–1158 · DOI: 10.5530/ijper.54.4.211 · Published 2020
Aim: The study was aimed to conduct a pharmacokinetic evaluation of Fluvastatin in rabbit plasma using a sensitive HPLC method. Materials and Methods: The plasma samples were assayed by Waters alliance e-2695 HPLC instru…
Article
Development of Validated Stability-indicating RP-HPLC Method for Determination of Novel Directly Acting Antiviral agent and Characterization of its Degradants by LC–ESI–MS
Babita Agarwal, Santosh Gandhi
pp. 1159–1168 · DOI: 10.5530/ijper.54.4.212 · Published 2020
Aim: The current study was performed to develop and validate stability indicating high performance liquid chromatography method (RP-HPLC) for determination of ledipasvir (LPR); to identify and characterize its major degr…
Article
Development of HPTLC Method for Estimation of Gallic Acid and Bergenin in Actaea acuminata Roots
Deepak Kumar, Reecha Madaan, Suresh Kumar
pp. 1169–1173 · DOI: 10.5530/ijper.54.4.213 · Published 2020
Introduction: The major drawback associated with herbal drugs is to get their reproducible therapeutic efficacy. Standardization of herbal drugs with marker compounds seems to be a viable solution to achieve their consis…
Article
Development and Validation of Novel UV Spectrophotometric Method for the Determination of Evogliptin Tartarate in Pharmaceutical Dosage Form
Yogesh Purushottam Agrawal, Mona Yogesh Agrawal, Siddhesh Bharat Jadhav, Renuka Jagannath Shinde
pp. 1174–1179 · DOI: 10.5530/ijper.54.4.214 · Published 2020
Aim: Development of a novel precise, selective and sensitive UV spectrophotometric method for the estimation of Evogliptin tartarate in bulk and tablet dosage forms. Materials and Methods: The estimation was carried out …
Article
Estimation of the Probability to Target Attainment to the Pharmacokinetic/ Pharmacodynamic Index of Ertapenem in Elderly Inpatients
Daniel Palma, Elena Vega, María Gai
pp. 1180–1183 · DOI: 10.5530/ijper.54.4.215 · Published 2020
Background: Infectious diseases are one of the most causes of hospitalization and death in adults in the elderly and this population is prone to develop complications and pharmacokinetic/pharmacodynamic changes. Objectiv…
Article
Community Pharmacist and Clinical Pharmacist Interventions using MMAS-8, FACIT, SF-12 among Pulmonary TB Patients Receiving Anti-TB Drugs from Urban Community Pharmacies, South India
Uday Kumar Rangaswamy, Madiwalayya Shivakantayya Ganachari
pp. 1184–1192 · DOI: 10.5530/ijper.54.4.216 · Published 2020
Aim and Objectives: To determine the professional interaction between community pharmacist and clinical pharmacist during the treatment of pulmonary tuberculosis (TB) patients at urban community pharmacy. Methods: A rand…
Article
Impacts of Digital Marketing on the Pharmacies Community in Saudi Arabia and Determining the Future Model of the Industry: A Cross-Sectional Questionnaire-based Study
Mansour Alyahya, Sneha Dhruvakumar, Shekar Hosahalli Siddegowda, Nagaraja Sreeharsha
pp. 1193–1206 · DOI: 10.5530/ijper.54.4.174 · Published 2020
Background: Pharmaceutical and telemedicine industries are now finding ways in the Kingdom of Saudi Arabia by adopting innovative and successful business models along with groundbreaking strategies using digital online p…