Volume 55, Issue 1

2021 · pp. 1–303 · 32 articles

Volume: 55
Issue: 1
Published: 2021
Pages: 1–303
Articles: 32
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Review Article Original Article

In this issue

Review Article

Review
Cucurbita pepo and Cucurbitacin in the Management of Anti-proliferation by JAK/STAT Pathway
Souvik Mukherjee, Dilipkumar Pal
pp. 1–10 · DOI: 10.5530/ijper.55.1.3 · Published 2021
Pumpkin (Cucurbita pepo) is capaciously recycled similar to food and in folk medicine throughout the world. It accords to genus Cucurbita (CCT) under family Cucurbitaceae. There are a plenty of important medicinal phyto-…
Review
World Wide Uncharted Trajectory Outbreak Initiator: Coronavirus [COVID-19] Pathogenesis
Gajula Chinna Devi
pp. 11–20 · DOI: 10.5530/ijper.55.1.4 · Published 2021
The Coronavirus (CoV) belongs to family of Coronaviridae, suborder Coronavirinae and Nidovirales order. CoV causes diseases in human with a just cold, cough and high fever symptoms simultaneously develops in to severe re…
Review
An Overview on Pharmaceutical Tendering Process
Silpa Jalagam, Muddukrishna Badamane Sathyanarayana
pp. 21–25 · DOI: 10.5530/ijper.55.1.5 · Published 2021
Objectives: World Health Organization (WHO) has implemented the Pharmaceutical tendering process for procuring the high-quality medicines from different firms to meet the needs of the countries which are having drug shor…
Review
A Brief Introduction of Clinical Chinese Pharmacy Education, Training and Practice in China
Zhijian Lin, Yue Li, Bing Zhang
pp. 26–35 · DOI: 10.5530/ijper.55.1.6 · Published 2021
In China, there are two types of pharmacists who work on either Western Medicine (WM) or Traditional Chinese Medicine (TCM). Both are responsible for the provision of pharmaceutical care with safe, effective, efficient a…
Review
Pharmacological Actions of Contents of Kabasura Kudineer- A Siddha Formulation for Fever with Respiratory Illness
Koppala Narayana Sunil Kumar, Kallingil Gopi Divya, Rubeena Mattummal, Bobbili Erni, Parameswaran Sathiyarajeswaran, Kadarkarai Kanakavalli
pp. 36–55 · DOI: 10.5530/ijper.55.1.7 · Published 2021
Siddha system of medicine is a distinct therapeutic science with many single drugs and compound formulations used for treating a broad spectrum of ailments. Siddha categorizes the fever manifested by viral infestation in…
Review
Problem-based Learning Teaching Method Applied to Pharmaceutical Engineering Experiment Teaching Based on the Outcome-based Education Theory
Chengjun Jiang, Guilin Cheng
pp. 56–62 · DOI: 10.5530/ijper.55.1.8 · Published 2021
Objectives: Pharmaceutical engineering experiments are among the most important links in teaching of the pharmaceutical engineering specialty. This study aimed to reform the content of the experiment course for the pharm…

Original Article

Article
Students’ Perception and Expectation towards Pharmacy Education: A Qualitative Study of Pharmacy Students in a Developing Country
Yolanda Choi, Jiangtao Wang, Yuxi Zhu, Wing-Fu Lai
pp. 63–69 · DOI: 10.5530/ijper.55.1.9 · Published 2021
Background: Pharmacy education is a vital element sustaining the supply of pharmacists to meet the needs in the social and health care sectors. Understanding the perception and expectation of pharmacy students towards th…
Article
Association between Personality Traits and Metacognition among Pharmacy Students: Implication for Pharmaceutical Education
Xianmin Hu, Jun Wang, Juan Liu, Yuhang Yao
pp. 70–76 · DOI: 10.5530/ijper.55.1.10 · Published 2021
Background: The importance of pharmacy practitioners’ personality traits in their professional development and future patient-centered pharmaceutical care practice has been widely recognized. Metacognitive skills in crit…
Article
Formulation and Optimization of Atovaquone Micronized Suspension by Top-down Method
Harsha Kathpalia, Sukanya Das, Supriya Shidhaye
pp. 77–85 · DOI: 10.5530/ijper.55.1.11 · Published 2021
Aim: The present work aimed to tackle the solubility issue of a Biopharmaceutics Classification System (BCS) II drug, Atovaquone. Methods: Formulation of micronized suspension of atovaquone was optimized by employing a 3…
Article
Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole
Vedanshu Malviya
pp. 86–94 · DOI: 10.5530/ijper.55.1.12 · Published 2021
Purpose: The main objective of present study is to evaluate the effect of various factors which have direct influence on the characteristic parameters of emulsomes formulation, so that optimized combination of factors ca…
Article
Preformulation Considerations Development and Evaluation of Mesalamine Loaded Polysaccharide-Based Complex Mucoadhesive Beads for Colon Targeting
Rohitas Deshmukh, Ranjit Kumar Harwansh
pp. 95–106 · DOI: 10.5530/ijper.55.1.13 · Published 2021
Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of large intestine consisting of ulcerative colitis and Crohn’s disease. Mesalamine is a first line drug use for the treatment but it has dra…
Article
Development and Characterization of Leuprolide Acetate Encapsulated PLGA Microspheres for Parenteral Controlled Release Depot Injection
Soumya Ranjan Satapathy, Rudra Narayan Sahoo, Biswaranjan Satapathy, Ramachandrarao Immani, Lalatendu Panigrahi, Subrata Mallick
pp. 107–116 · DOI: 10.5530/ijper.55.1.14 · Published 2021
Objectives: Polylactic acid (PLA) and copolymer polylactic-co-glycolic acid (PLGA) are the most versatile drug carriers for long acting release injectable (LAI) formulations for small molecules, peptides and macromolecul…
Article
Doxorubicin Hydrochloride Loaded Polyanhydride Nanoformulations and Cytotoxicity
Nagaraja Sreeharsha, Jagadeesh G Hiremath, Prashanth Kumar R, Girish Meravanige, Saleemulla Khan, Ranjith Kumar Karnati, Mahesh Attimarad, Bandar Al-Dhubiab, Anroop Balachandran Nair, Katharigatta Narayanaswamy Venugopala
pp. 117–125 · DOI: 10.5530/ijper.55.1.2 · Published 2021
This study aimed to evaluate DOX∙HCl loaded P(DLLA-CO:60:40) nanoformulations with a copolymer of F127 as a potential drug delivery system for cancer. DOX ∙ HCl was encapsulated in nanoformulations of Poly DL-lactic acid…
Article
Protective Effect of Natrium Diethyldithiocarbamate Trihydrate (NDDCT) on Lead Induced Neurodegeneration in Rats
Sudhir Kumar, Harikesh Maurya, Sandeep Sandeep, Saikat Sen, Raja Chakraborty
pp. 126–135 · DOI: 10.5530/ijper.55.1.15 · Published 2021
Aim: Lead is a powerful metal which induced neurotoxicity through the degradation of neurons in the body. Various neuronal changes have shown correlation with the generation of free radicals and oxidative stress. The pre…
Article
Paralleling the Quality and Economy of Levofloxacin Hemihydrate and Cefuroxime Axetil Tablets
Atmaram Pawar, Mahesh Chainpure, Vividha Dhapte-Pawar
pp. 136–145 · DOI: 10.5530/ijper.55.1.16 · Published 2021
Aim/Background: The Government of India has initiated different regulations and provisions to provide low cost medicines at affordable rates than the high cost medicines. The government has initiated Jan Aushadhi stores …
Article
Disposal of Uranium and Thorium Entering the Human Digestive System before Reaching the Blood by Adsorption on Simethicone and Forming a Non-absorbable Compound: A Full in vitro Analysis
Hamed Ibrahim Mira, Nashat Mohamed Alanwar Abdalaty
pp. 146–152 · DOI: 10.5530/ijper.55.1.1 · Published 2021
Introduction: This method was applied to form a non-absorbable complex with uranium and thorium swallowed with contaminated dust or other sources to get rid of them before absorption into the blood and discarded outside …
Article
Alpha7 Nicotinic Acetylcholine Receptor Down Regulation Impairs Mitochondrial Function in Streptozotocin-induced Sporadic Alzheimer's Disease Model in Rats
Niraj Kumar Singh, Debapriya Garabadu
pp. 153–163 · DOI: 10.5530/ijper.55.1.17 · Published 2021
Background/Aim: Alzheimer’s disease (AD), a type of neurodegenerative disorder, possesses significant memory loss as one of the cardinal manifestations. The pathophysiology of AD includes increased accumulation of Aβ, de…
Article
Pharmacological Evaluation of Caesalpinia pulcherrima Leaf Extract for Anticancer Activity against Ehrlich Ascites Carcinoma Bearing Mice
Shamanand Mallapur, Prakash Rajshekhar Biradar, Satish Annayya Kavatagimath, Priyanka Patil, Vishal Patil, Namit Kudatarkar
pp. 164–173 · DOI: 10.5530/ijper.55.1.18 · Published 2021
Objectives: The aim of the study is to assess the anticancer activity of Caesalpinia pulcherrima leaf extract against Erlich Ascites Carcinoma (EAC) in mice. Materials and Methods: BALB/c mice with Erlich Ascites Carcino…
Article
Revisiting Therapeutic Potentials of Ethanolic Extract of Curcuma longa L. rhizomes to Evaluate wound Healing Progression upon Topical Application of its Ointment
Tathagata Adhikary, Chowdhury Mobaswar Hossain, Sougata Mallick, Samrat Paul, Nisha Banerjee, Piyali Basak
pp. 174–183 · DOI: 10.5530/ijper.55.1.19 · Published 2021
Background and Aim: The goodness of turmeric is claimed traditionally but providing proper scientific data will not only support the statements making it more evident but will also search for possible ways to enhance its…
Article
Electroencephalogram Correlates the Role of Ashwagandha in Sleep and Memory Promoting Effect
Mounika Basani, Ramesh Malothu, Rakesh Kumar Sinha, Sindgi Vasudeva Murthy
pp. 184–189 · DOI: 10.5530/ijper.55.1.20 · Published 2021
Background: Ashwagandha (Withania somnifera), a known traditional medicine used in Ayurveda system of medicine, native to the India. Poor quality sleep always looked as serious complaint as it disrupts sleep. The natural…
Article
Inhibitory Potential of Dietary Phytocompounds of Nigella sativa against Key Targets of Novel Coronavirus (COVID-19)
Pratibha Pandey, Fahad Khan, Avijit Mazumder, Ansh Kumar Rana, Yashvi Srivastava
pp. 190–197 · DOI: 10.5530/ijper.55.1.21 · Published 2021
Aim/Background: Dietary factors have shown important role in the rapid management of several human ailments including viral infections. Since ancient times, constituents of Nigella sativa seeds have been utilized as food…
Article
Safety Evaluation of Syzygium jambolanum on the Development of Zebrafish Embryos
Mahima Sharma, Suneel Prajapati, Arun Kumar, Ashish Tripathi, GV Narasimha Kumar, Pankaj Gupta
pp. 198–204 · DOI: 10.5530/ijper.55.1.22 · Published 2021
Background: Gestational diabetes mellitus, a hyperglycaemic condition that develops at the time of pregnancy, causes approximately 7% of complications during pregnancies world wide. Syzygium jambolanum has been proved cl…
Article
Antiproliferative Potential of Ethyl acetate Extract of Clerodendrum thomsoniae Balf.f. on DMBA-induced Breast Cancer in Female Sprague-dawley Rats
VK Muhammed Ashraf, VK Kalaichelvan, R Ragunathan, VV Venkatachalam
pp. 205–214 · DOI: 10.5530/ijper.55.1.23 · Published 2021
Background: Clerodendrum is a genus of around 500 species that has a place with the family Lamiaceae. Numerous types of this class have been demonstrated for the treatment of different maladies including cancer. This stu…
Article
Ameliorative Effect of Multi Herbal Formulation on Lipid Peroxidation and Redox Dysfunction in Ethanol Induced Hepatic Imbalance
Soumendra Darbar, Srimoyee Saha, Kaushikisankar Pramanik, Atiskumar Chattopadhyay
pp. 215–223 · DOI: 10.5530/ijper.55.1.24 · Published 2021
Objectives: Traditional medicine is a potent antioxidant. In the present study, we developed a multi herbal formulation and examined its anti-oxidative activities and possible protective effect of it on serum and liver l…
Article
Bioactivity of Dodecanoic Acid Extracted from Geitlerinema sp. TRV57
Renugadevi K, Valli Nachiyar C, Moin Zaveri
pp. 224–231 · DOI: 10.5530/ijper.55.1.25 · Published 2021
Aim/Background: Imbalance in oxidant and antioxidant leads to oxidant stress. Increased consumption of exogenous antioxidants helps in neutralizing the oxidant stress and thus protects the cells from oxidant stress. The …
Article
Evaluation of Anti-urolithiatic Potential of Leaves of Alstonia scholaris and its Isolated Pentacyclic Triterpenoids in Ethylene Glycol-induced Renal Calculi Rat Model
Zehra S, Sanaye MM
pp. 232–239 · DOI: 10.5530/ijper.55.1.26 · Published 2021
Introduction: Urolithiasis has afflicted human race since the days of yore. Conventional treatment acts only on associated ailments whereas pharmacologically active phytoconstituents derived from plants are reported to p…
Article
Tribulus terrestris Saponins Improve Ovarian Ischemia-reperfusion Injury in Female Rats: Modulation of Vascular Endothelial Growth Factor-A and Hemeoxygenase-1
Asmaa Mohamed Abdel-Aziz, Hanaa Hassanein Mohammed, Osama Abdelazem, Rasha Fouad Ahmed, Yasmine F. Ibrahim
pp. 240–248 · DOI: 10.5530/ijper.55.1.27 · Published 2021
Aim/Background: Ovarian I/R is a popular gynecological emergency, complicating ovarian torsion. TTS, reported to have many therapeutic effects along with being an antioxidant, anti- inflammatory and anti-apoptotic agent.…
Article
Appliance of the ICH Guidelines: Forced Degradation Studies on Abafungin and Development of Validated Stability Indicating Method by 1st Order Derivative Spectroscopy
Swati Pandey, Ravindra Pandey, Shiv Shankar Shukla
pp. 249–255 · DOI: 10.5530/ijper.55.1.28 · Published 2021
Background: The presented study is a stability indicating simple, precise and accurate 1st order UV derivative spectroscopic method that is being studied under the different stated International Council for Harmonization…
Article
Docking Studies, Synthesis and Evaluation of Anticancer Activity of 4H-Chromene Derivatives
Piyush Kumar, Pinki Rawat
pp. 256–265 · DOI: 10.5530/ijper.55.1.29 · Published 2021
Aim: The present study involves to design, synthesis and evaluate the anticancer activity of 4H-chromene derivatives (PKB 1-10) on human breast cancer MCF-7 cell line. Materials and Methods: 4H-chromene derivatives (PKB …
Article
Design, Synthesis, Hypoglycemic Activity and Molecular Docking Studies of 3-substituted-5- [(furan-2-yl)-methylene]-thiazolidine-2,4-dione Derivatives
Karumanchi Srikanth Kumar, Atmakuri Lakshmana Rao, Dachuru Rama Sekhara Reddy
pp. 266–275 · DOI: 10.5530/ijper.55.1.30 · Published 2021
Background: From the wide range of previous literature studies indicated that thiazolidinedione’s reacts with substituted benzaldehydes undergoes knoevenagel condensation gives respective arylidene derivatives. In our at…
Article
Research on the Attitudes of the Elderly towards Interprofessional Cooperation and Collaborative Pharmacy Practices: Cross-sectional Study in Serbia
Velibor O Ilić, Ljiljana Tasić, Valentina Marinković
pp. 276–287 · DOI: 10.5530/ijper.55.1.31 · Published 2021
Background: Population aging is taking place at the highest historical rates, while growing needs for healthcare by the elderly put added and immense pressure predominantly on the primary care. Higher level of interprofe…
Article
Re-Appraisal of the Effectiveness and Adverse Reaction between Cefazolin and Anti-Staphylococcal Penicillins for Treating Patients with Methicillin- Sensitive Staphylococcus aureus Bacteremia: Comprehensive Meta-analysis and Trial Sequential Analysis
Chang-Hua Chen, Yu-Min Chen, Hsien-Meng Chen, Yu-Jun Chang, Li-Jhen Lin, Hua-Cheng Yen
pp. 288–303 · DOI: 10.5530/ijper.55.1.32 · Published 2021
Objectives: Patients with methicillin susceptible Staphylococcus aureus bacteremia (MsSaB) are treated by cefazolin (Cfz) or anti-staphylococcal penicillin’s (ASPs) as the preference drug, although they may be not equall…