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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Disposal of Uranium and Thorium Entering the Human Digestive System before Reaching the Blood by Adsorption on Simethicone and Forming a Non-absorbable Compound: A Full in vitro Analysis

Hamed Ibrahim Mira1, Nashat Mohamed Alanwar Abdalaty2★★ Corresponding author

  1. 1Professor of Geochemistry and Chairman of Nuclear Material Authority, Nuclear Materials Authority, Maadi, Cairo, EGYPT.
  2. 2Department of Medicinal and Radiation Research, Nuclear Materials Authority, Maadi, Cairo, EGYPT.

CORRESPONDENCE

Nashat Mohamed Alanwar Abdalaty

Department of Medicinal and Radiation Research, Nuclear Materials Authority, Maadi, Cairo, EGYPT.

nashat.alanwar@yahoo.com

Received: 17-04-2020; Revised: 13-08-2020; Accepted: 23-11-2020.

Volume 55, Issue 1 · pp. 146–152 · PUBLISHED 2021 · DOI: 10.5530/ijper.55.1.1

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ABSTRACT

Introduction: This method was applied to form a non-absorbable complex with uranium and thorium swallowed with contaminated dust or other sources to get rid of them before absorption into the blood and discarded outside the body. A non-GIT absorbable simethicone was used in this method for the adsorption of uranium (VI) and thorium (IV) from a solution similar to the gastrointestinal tract pH medium. Materials and Methods: Accurately measured 9 mg of pure standard uranyl nitrate and simethicone emulsion in concentration range (100-300 mg) at 37±1°C for 20 min in pH ranges like the medium of the stomach and intestine then take the supernatant after centrifugation to make sure of decreasing of the concentration of uranium and thorium ions by ICP Mass Spectroscopy (ICP-MS). Results and Discussion: The data recorded for different total uranium and thorium concentrations reveal convergent behavior. Increasing simethicone concentration inside the safe dose shifts the sorption of uranium and thorium to 100 % of the total concentration, calculated t and F values were compared with the reference method and the proposed method was equally precise and accurate. Conclusion: The data indicate that the method can successfully be applied for the complete adsorption of uranium and thorium on simethicone from GIT before reaching the blood.

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    Mira, H. I., & Abdalaty, N. M. A. (2021). Disposal of Uranium and Thorium Entering the Human Digestive System before Reaching the Blood by Adsorption on Simethicone and Forming a Non-absorbable Compound: A Full in vitro Analysis. Indian Journal of Pharmaceutical Education and Research, 55(1), 146–152. https://doi.org/10.5530/ijper.55.1.1